2026
article
OpenAlex
Prashant Menon, Monish Kumar, Jayashree Kanagarajan, Yichen Zhan et autres
Abstract Introduction Despite the remarkable success of chimeric antigen receptor (CAR) T cell therapy in hematological cancers, the clinical experience with solid tumors has not been encouraging. Preclinical and clinical data support that the tumor-specific extracellular matrix (ECM) presents a physical barrier …
us
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2026
conference-abstract
OpenAlex
W. Zhang, Adil Bahadir, Zhongting Zhang, Yianhua Yi et autres
Abstract Background: Osteosarcoma outcomes have not improved in over three decades, and prognosis remains poor for patients with pulmonary metastases. B7-H3 is highly expressed on osteosarcoma with limited normal-tissue expression, making it an attractive therapeutic target. This study evaluated the antitumor activity …
us
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
J. S. Hu, Harjeet Singh, Yining Jin, W. Zhang et autres
Abstract Tumor-targeted T-cell therapies of various types have been booming, but T-cell therapy is limited by its inability to penetrate the collagen barrier that “stuffed” within tumors and surrounding tumors/tumor cells. Compared to normal human tissues, sarcoma tissues exhibited significantly higher density …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Pierantonio Russo, Ramaa Nathan, Juliana Poh, Harjeet Singh et autres
Introduction: Chronic kidney disease (CKD), a key element of the AHA Cardiovascular-Kidney-Metabolic (CKM) framework, is increasingly recognized as an independent risk factor for arrhythmias, especially atrial fibrillation (AF). Studies like ARIC and recent guidelines highlight higher arrhythmia risk with declining kidney function, …
ca, us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Pierantonio Russo, Ramaa Nathan, Juliana Poh, Harjeet Singh et autres
Introduction: The AHA Cardiovascular-Kidney-Metabolic (CKM) framework outlines a continuum of risk, starting with metabolic dysfunction and leading to major cardiovascular events. However, the role and timing of arrhythmia onset within this trajectory remain poorly understood, and the impact of major arrhythmias has …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Pierantonio Russo, Ramaa Nathan, Juliana Poh, Harjeet Singh et autres
Background: While CKD is a known risk factor for arrhythmias, the reverse association, arrhythmias preceding CKD, is also recognized. Emerging evidence highlights a bidirectional relationship between the two conditions. This study focuses on the scenario in which arrhythmias precede CKD, aiming to …
us
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Accès ouvert
2025
article
OpenAlex
Jiemiao Hu, Harjeet Singh, Yining Jin, W. Zhang et autres
Abstract Description Tumor-targeted T-cell therapies is limited by its inability to penetrate the collagen barrier surrounding tumors. Our previously reported cell surface vimentin (CSV)–targeted and membrane-anchored IL12-armed (attIL12) T cells can reduce collagen production by killing cancer-associated fibroblasts but cannot reduce collagen …
us
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Accès ouvert
2025
article
OpenAlex
Jiemiao Hu, Harjeet Singh, Yining Jin, W. Zhang et autres
Tumor-targeted T cell therapies of various types have been booming, but T cell therapy is limited by its inability to penetrate the collagen barrier surrounding tumors. The destruction of tumor collagen is significant because collagen both suppresses T cells and contributes to …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Pierantonio Russo, Ramaa Nathan, Juliana Poh, Harjeet Singh et autres
AIMS: Cardiac arrhythmias are common in chronic obstructive pulmonary disease (COPD) and are associated with poor outcomes. Their impact on healthcare resource utilization (HCRU) and costs is increasingly recognized. The incremental economic burden of arrhythmias in patients with COPD and the impact …
ca, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Saroj Kumar Debnath, Harjeet Singh, M Akashlal, Jishin Prakash TS
Amavata is a painful chronic systemic disease with special involvement of multiple joints, and it is more similar to Rheumatoid arthritis according to its clinical manifestations and pathogenesis. Amavata (Rheumatoid arthritis) is a burning problem in society because a suitable, effective standard …
in
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Accès ouvert
2025
article
OpenAlex
Pappanaicken R. Kumaresan, Sourindra N. Maiti, Paul Hauser, Harjeet Singh et autres
In hematopoietic stem cell transplantation (HSCT), donor-derived allogeneic T cells contribute to the graft-versus-tumor (GVT) effect but can also trigger graft-versus-host disease (GvHD), a major source of post-transplant morbidity and mortality. Regulatory T cells (Tregs), particularly FoxP3⁺ Tregs, play a pivotal role …
us, in
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Zhongting Zhang, Wendong Zhang, Xin Zhou, Caterina Longo et autres
Abstract Instruction: Antibody-drug conjugates (ADCs) are a rapidly advancing therapeutic approach. A proof of principle CADM1 ADC has shown significant efficacy in osteosarcoma preclinical studies; however, its activity may be compromised by inherent or acquired resistance during prolonged treatment. In this study …
us
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