Paul Hauser

Prolyl-tRNA synthetase inhibition disrupts oncogenic translation in T-cell acute lymphoblastic leukemia

Valerio Ciaurro, Abdul Khalique, Priyanshu Srivastava, Yu Zhou et autres

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer marked by the abnormal growth of immature thymocytes. 5-year survival rate in T-ALL is about 85% in children and less than 50% in adults. Relapsed/refractory T-ALL remains a major clinical challenge, …

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Isolation and Expansion of Clinical Grade T Regulatory Cells for GvHD Prophylaxis

Pappanaicken R. Kumaresan, Sourindra N. Maiti, Paul Hauser, Harjeet Singh et autres

In hematopoietic stem cell transplantation (HSCT), donor-derived allogeneic T cells contribute to the graft-versus-tumor (GVT) effect but can also trigger graft-versus-host disease (GvHD), a major source of post-transplant morbidity and mortality. Regulatory T cells (Tregs), particularly FoxP3⁺ Tregs, play a pivotal role …

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CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL THERAPY FOR ASPERGILLOSIS.

Parveen Kumar, Sebastian Wurster, T. Claro DaSilva, Paul Hauser et autres

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A novel lentiviral vector-based approach to generate CAR T cells targeting Aspergillus fumigatus

Pappanaicken R. Kumaresan, Sebastian Wurster, Thiago Junqueira Avelino‐Silva, Karishma Bavasi et autres

Abstract Invasive aspergillosis (IA) is a common and deadly mold infection in immunocompromised patients. As morbidity and mortality of IA are primarily driven by poor immune defense, adjunct immunotherapies, such as chimeric antigen receptor (CAR) T cells, are direly needed. Here, we …

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A novel lentiviral vector-based approach to generate chimeric antigen receptor T cells targeting Aspergillus fumigatus

Pappanaicken R. Kumaresan, Sebastian Wurster, Karishma Bavisi, Thiago Aparecido da Silva et autres

ABSTRACT Invasive aspergillosis (IA) is a common and deadly mold infection in immunocompromised patients. As morbidity and mortality of IA are primarily driven by poor immune defense, adjunct immunotherapies, such as chimeric antigen receptor (CAR) T cells, are direly needed. Here, we …

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Abstract 1186: Examining the Role of nmr-1 in Caenorhabditis elegans Behavioral Response to Antipsychotic Drugs as a Model for Glutamatergic Dysfunction in Schizophrenia

Lauren Stoffel, Kyra Hong, Max Manning, Micah Brown et autres

Abstract 1227: Journal Club: A Sustainable Model for Accessible Science Education and Transferability

Lauren Stoffel, P. Choi, Juliet Sostena, Sasha Cocquyt et autres

Abstract 1188: Codon Optimization of saCas9 Gene Enhances Protein Expression in Human Kidney Cells to Compensate for Difficulties in Delivery Vectors to Boost CRISPR-Cas9 in vivo Therapeutic Application

Anoushka Krishnan, Zander Chierici, Dhruv Chinmay, Hannah Drew et autres

Abstract 1194: Project80 3.0: An Updated Student-Driven Framework for Creating Multimedia Educational Resources from Primary Literature

Anoushka Krishnan, Micah Brown, Houjun Liu, Grace E. Holmes et autres

Abstract 1178: R@N: an Asynchronous, Student-Led Program to Train Students to Conduct Independent Research

Houjun Liu, Michael Sarboraria, Vinca Lu, Kian Salimi et autres

Abstract 1198: Machine-Learning Assisted Residue Optimization of Laccases for Dye Decolorization

Zachary Sayyah, P. Choi, Owen Hsu, Paul Hauser et autres

400 PDGFRα-specific CAR T cell therapy of pediatric high-grade glioma

Kathryn Eckholdt, Sara Mazrimas, Paul Hauser, Wafik Zaky et autres

Background Platelet-derived growth factor receptor alpha (PDGFRα) is a tyrosine kinase receptor that plays a pivotal role in tumorigenesis and is associated with tumor proliferation and progression. Pediatric gliomas are known to express high levels of PDGFRα, designating the receptor a viable …

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