Kazuhiko Matsuo

A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation

Daisuke Kobayashi, Akihiro Urasaki, Tetsuaki Kimura, Satoshi Ansai et autres

Congenital intestinal atresia (IA) is a birth defect characterised by the absence or closure of part of the intestine. Although genetic factors are implicated, mechanistic understanding has been hindered by the lack of suitable animal models. Here, we describe a medaka (Oryzias …

jp, ie, cn (code pays fourni par la source)

C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation

Aga Krisnanda, Naoto Sasaki, Toru Tanaka, Ken Ito et autres

Background The dysregulated immune system, which drives chronic vascular inflammation and remodeling, plays a critical role in the pathogenesis of abdominal aortic aneurysm (AAA). CCR4 (C‐C chemokine receptor 4), which is predominantly expressed on T cells and mediates their responses, has been …

jp (code pays fourni par la source)

Focal adhesion-related non-ciliary functions of CEP290

Kazuhiko Matsuo, Yoshiro Nakajima, Masaki Shigeta, Daisuke Kobayashi et autres

Nearly all differentiated mammalian cells possess primary cilia on their surface. Ciliary dysfunction causes ciliopathy in humans. Centrosomal protein 290 (CEP290), a ciliary protein implicated in ciliopathies, localizes to the ciliary base and the centrosome in ciliated cells. CEP290-related ciliopathies arise from …

jp (code pays fourni par la source)

Author response: C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

jp (code pays fourni par la source)

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although C-C …

jp (code pays fourni par la source)

Author response: C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although C-C …

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Abstract Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although …

jp, id (code pays fourni par la source)

Involvement of chemokines and these receptors in glioblastoma

Yuta Hara, Kazuhiko Matsuo, Takashi Nakayama

Chemokines are a group of cytokines which are involved in the migration of immune cells as well as other cell types such as endothelial cells. These molecules normally regulate the homeostasis in our body's immune system. Furthermore, it has been reported that …

jp (code pays fourni par la source)

Author response: C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although C-C …

jp (code pays fourni par la source)

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Abstract Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although …

jp, id (code pays fourni par la source)

Sonic Hedgehog signaling regulates the optimal differentiation pace from early‐stage mesoderm to cardiogenic mesoderm in mice

Satoshi Inoue, Moe Nosetani, Yoshiro Nakajima, Shinichiro Sakaki et autres

Abstract Sonic Hedgehog ( Shh ), encoding an extracellular signaling molecule, is vital for heart development. Shh null mutants show congenital heart disease due to left–right asymmetry defects stemming from functional anomaly in the midline structure in mice. Shh signaling is also …

jp (code pays fourni par la source)

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Abstract Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although …

jp, id (code pays fourni par la source)