Naoto Sasaki

Enhanced accumulation of protoporphyrin IX via SLC6A6 and SLC36A1 sensitizes cisplatin-resistant cells to 5-aminolevulinic acid-based photodynamic therapy

Sayo Horibe, Toru Tanaka, Shoji Kawauchi, Naoto Sasaki et autres

Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is a promising treatment for cancer cells. Although cisplatin (CDDP) is a potent anticancer drug, acquired resistance often limits its clinical efficacy. This study aimed to evaluate the effectiveness of 5-ALA-PDT in CDDP-resistant cancer cells …

jp (code pays fourni par la source)

A Single-Cell Analysis Reveals Macrophage Heterogeneity Driving Plaque Vulnerability in Coronary and Carotid Arteries

Takeshi Yoshida, Takuo Emoto, Hiroyuki Yamamoto, Tomofumi Takaya et autres

AIM: Acute coronary syndrome (ACS) and ischemic stroke are major life-threatening conditions caused by atherosclerosis. Although the mechanisms of atherosclerosis appear to be broadly similar across different vascular beds, growing evidence suggests that there are morphological and histological differences between coronary and …

jp, no (code pays fourni par la source)

C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation

Aga Krisnanda, Naoto Sasaki, Toru Tanaka, Ken Ito et autres

Background The dysregulated immune system, which drives chronic vascular inflammation and remodeling, plays a critical role in the pathogenesis of abdominal aortic aneurysm (AAA). CCR4 (C‐C chemokine receptor 4), which is predominantly expressed on T cells and mediates their responses, has been …

jp (code pays fourni par la source)

284 nm UVB Phototherapy Regulates Immunoinflammatory Responses and Improves Atherosclerotic Plaque Stability in Mice.

Ken Ito, Naoto Sasaki, Aga Krisnanda, Toru Tanaka et autres

AIM: We previously reported that broad-band and specific wavelengths of ultraviolet B (UVB) limit the development of atherosclerosis by augmenting anti-inflammatory immune responses in hypercholesterolemic mice. This study aimed to elucidate the effect of 284 nm UVB on the stabilization of atherosclerotic …

jp (code pays fourni par la source)

Author response: C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

jp (code pays fourni par la source)

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although C-C …

jp (code pays fourni par la source)

Author response: C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although C-C …

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Abstract Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although …

jp, id (code pays fourni par la source)

312 nm UVB Phototherapy Limits Atherosclerosis by Regulating Immunoinflammatory Responses in Mice.

Aga Krisnanda, Naoto Sasaki, Ken Ito, Toru Tanaka et autres

AIM: Our previous studies identified ultraviolet B (UVB) irradiation as a possible approach for preventing atherosclerosis. The aim of this study was to clarify the effect of 312 nm UVB, a wavelength similar to that of clinically available narrow-band UVB for the …

jp, id (code pays fourni par la source)

Author response: C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although C-C …

jp (code pays fourni par la source)

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Abstract Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although …

jp, id (code pays fourni par la source)

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

Toru Tanaka, Naoto Sasaki, Aga Krisnanda, Hilman Zulkifli Amin et autres

Abstract Chronic inflammation via dysregulation of T cell immune responses is critically involved in the pathogenesis of atherosclerotic cardiovascular disease. Improving the balance between proinflammatory T cells and anti-inflammatory regulatory T cells (Tregs) may be an attractive approach for treating atherosclerosis. Although …

jp, id (code pays fourni par la source)