Brian Long

Acute and Long-Term Immune-Treatment Strategies in Anti-LGI1 Antibody–Mediated Encephalitis

Nabil Seery, Robb Wesselingh, Paul Beech, Laurie McLaughlin et autres

BACKGROUND AND OBJECTIVES: Few studies have evaluated acute immunotherapy and relapse prevention strategies in patients with anti-leucine-rich glioma-inactivated 1 (LGI1) antibody (Ab)-mediated encephalitis. The objective of this study was to analyze the outcomes of acute and long-term immunotherapy strategies in this population. …

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Invisible difficulties are easily missed when visible outcomes are positive: A qualitative study of patient perspectives following acute treatments for ischaemic stroke

Sam Humphrey, Kerryn Elizabeth Pike, Brian Long, Henry Ma et autres

We aimed to explore the perspectives of ischaemic stroke patients treated with endovascular clot retrieval (ECR), intravenous tissue plasminogen activator (t-PA), or conservative management in the early stages of stroke recovery. Thirty-one semi-structured interviews were qualitatively analysed using a reflexive thematic analysis …

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Neuropsychological outcomes following endovascular clot retrieval and intravenous thrombolysis in ischemic stroke

Sam Humphrey, Kerryn Elizabeth Pike, Brian Long, Henry Ma et autres

OBJECTIVES: Cognitive impairment, anxiety, depression, fatigue, and dependence in instrumental activities of daily living (ADL) are common after stroke; however, little is known about how these outcomes may differ following treatment with endovascular clot retrieval (ECR), intravenous tissue plasminogen activator (t-PA), or …

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F097 An economic and social productivity cost analysis of Huntington’s disease in Australia

Melanie L. Clark, Julie Abimanyi-Ochom, Long Khanh‐Dao Le, Brian Long et autres

Background Huntington’s disease (HD) requires complex intervention for decades. The burden on the Australian public is unknown. Aims This study aimed to explore the productivity losses, social burden, and cost of HD in Australia. Methods We used the Enroll-HD database to assess …

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Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms

Sarah P. Griffith, Robb Wesselingh, Nabil Seery, Tiffany Rushen et autres

BACKGROUND AND OBJECTIVE: Autoimmune encephalitis (AE) is often associated with clinically significant memory impairment. This study aimed to evaluate memory in a cross-sectional prospective AE cohort using multiple memory paradigms. METHODS: 52 patients (50% seropositive) meeting Graus criteria for possible AE were …

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Language impairments in seropositive and seronegative autoimmune encephalitis

Sarah P. Griffith, Robb Wesselingh, Fiore D’Aprano, Nabil Seery et autres

BACKGROUND AND OBJECTIVE: Autoimmune encephalitis (AE) is a rare neuroinflammatory disease affecting the central nervous system. To examine language functions in patients with different subsets of AE consisting of seropositive and seronegative groups. METHODS: Fifty-two patients were recruited from neurology departments in …

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What does cognitive screening reveal about early cognitive performance following endovascular clot retrieval and intravenous thrombolysis in acute ischaemic stroke?

Sam Humphrey, Kerryn Elizabeth Pike, Brian Long, Henry Ma et autres

Background Little is known regarding cognitive outcomes following treatment with endovascular clot retrieval (ECR) and intravenous tissue plasminogen activator (t-PA). We aimed to determine if there were any differences on a measure of cognitive screening between patients treated with ECR, t-PA, and …

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Characterizing cognitive function in patients with autoimmune encephalitis: an Australian prospective study

Sarah P. Griffith, Robb Wesselingh, Nabil Seery, Tiffany Rushen et autres

OBJECTIVE: This study uses the Wechsler intelligence and memory scales to characterize the cognitive function of patients with autoimmune encephalitis (AE) in the chronic stage of the disease. AE is a group of neuroinflammatory disorders, and cognitive impairment is a significant source …

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2785 Executive dysfunction in patients with autoimmune encephalitis – a study of Australian autoimmune encephalitis consortium

Sarah P. Griffith, Robb Wesselingh, Nabil Seery, Tiffany Rushen et autres

Objectives The objective of this study was to characterise executive functions (EF), and determine which aspects of EF are most affected in patients with Autoimmune Encephalitis (AE). Methods 52 patients who met the criteria for possible AE were recruited prospectively across tertiary …

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2781 Memory outcomes in patients with autoimmune encephalitis – a study of the Australian autoimmune encephalitis consortium

Sarah P. Griffith, Robb Wesselingh, Nabil Seery, Tiffany Rushen et autres

Background & Objective Patients with autoimmune encephalitis (AE) can present with a variety of memory complaints. However, it is difficult to draw strong conclusions regarding memory as there has been significant heterogeneity in the assessment of memory in this group. Methods 52 …

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A systematic review and meta-analysis of depression and apathy frequency in adult-onset Huntington’s disease

Melanie L. Clark, Julie Abimanyi-Ochom, Ha Le, Brian Long et autres

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Supplementary Figure Legend from Preclinical Evaluation of the WEE1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy

Amy D. Guertin, Jing Li, Yaping Liu, Melissa S. Hurd et autres

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