Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms
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Le résumé fourni par la source
BACKGROUND AND OBJECTIVE: Autoimmune encephalitis (AE) is often associated with clinically significant memory impairment. This study aimed to evaluate memory in a cross-sectional prospective AE cohort using multiple memory paradigms. METHODS: 52 patients (50% seropositive) meeting Graus criteria for possible AE were prospectively recruited between October 2019 and August 202. A comprehensive examination of memory was performed, including tests of supraspan verbal memory (list learning), logicosemantic memory (story learning), figural memory (learning of geometric designs), and verbal associative learning (verbal paired associates). Memory scores were compared to demographically adjusted normative data. Pattern analysis was conducted to assist in the identification of patterns in memory performances. RESULTS: Mean memory scores were not significantly below the normative mean. At an individual patient level, over 20% of the cohort exhibited impaired delayed figural memory, supraspan verbal memory learning and recall. Observed performances were significantly below expected performance for story learning (p = 0.017) and recall (p = 0.003), figural recall (p < 0.0001), initial acquisition (p < 0.001) and final acquisition of a list (p < 0.001) and all delayed recall measures of the list (p < 0.00001). 54.76% of patients exhibited intact psychometrics, and 16 distinct patterns of impairment emerged, indicating variability in memory outcomes. DISCUSSION: While statistical evidence for memory impairment did not emerge at an aggregate level, a proportion of patients present with evidence of abnormal memory performance on psychometrics. Variability in impaired memory measures argues for an individualised patient-focused approach to clinical assessment in AE. Future research should validate these findings with a larger sample size and explore the relationships between memory profiles and other cognitive functions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms
- Date Crossref
- 25/06/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Alfred Health pays non établi dans la noticeÉtablissement de santé
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Monash University Department of Neurosciences pays non établi dans la noticeUniversité ou école supérieure
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Box Hill Hospital pays non établi dans la noticeÉtablissement de santé
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Eastern Health pays non établi dans la noticeÉtablissement de santé
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Melbourne Health pays non établi dans la noticeÉtablissement de santé
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Monash Health pays non établi dans la noticeÉtablissement de santé
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The Royal Melbourne Hospital pays non établi dans la noticeOrganisme public
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The University of Melbourne Royal Melbourne Hospital pays non établi dans la noticeUniversité ou école supérieure
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Australian Psychological Society pays non établi dans la noticeInstitution
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Monash Alfred Psychiatry Research centre pays non établi dans la noticeStructure de recherche
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Department of Neurology pays non établi dans la noticeInstitution
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Faculty of Medicine Department of Neurosciences pays non établi dans la noticeUniversité ou école supérieure
Alfred Health, Department of Neurosciences — Monash University et Box Hill Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.