Wei Hu

Discovery of potent, selective and insurmountable MRGPRX2 antagonists for mast cell-driven disorders 2308475

Yves Millet, Josh Close, Wei Hu, Elena Dal Ferro et autres

Abstract Introduction Mas-related G protein—coupled receptor X2 (MRGPRX2) is an important mediator of non-IgE—dependent mast cell activation and has emerged as a key target in pseudo-allergic reactions and chronic inflammatory diseases. Yet, drugs targeting this mechanism remain limited. We report the discovery …

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Multi-Modal UAV Inspection of Photovoltaic Modules Using a YOLOv9-Based Fusion Network

Qing Yi, S. Mat Su, Wei Hu, Ke Wang et autres

The rapid expansion of photovoltaic (PV) power plants has created a pressing need for efficient and reliable operation and maintenance (O&M). Traditional manual inspection is slow, costly, and prone to error, motivating the use of unmanned aerial vehicles (UAVs) with infrared and …

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Multi-omics-Based Prognostic Prediction for Locally Advanced Hypopharyngeal Cancer Treated with Postoperative Chemoradiotherapy: A Dual-Center Study

Suwei Dong, Jie Wang, Xiaomin Ou, Wei Hu et autres

New role of obscure acylation modifications in cardiovascular diseases: what's beyond?

Zhongyi Zhang, Wei Hu, Qian Ding, Yi Zhun Zhu

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BLU-808: A Potent and Selective Oral Small Molecule Wild-Type KIT Tyrosine Kinase Inhibitor for Allergic Conditions

Megan A. Hatlen, Andrew M. Haidle, Doug Wilson, Priyanka Sawant et autres

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Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection (Adv. Sensor Res. 1/2025)

Jingyu Sun, Wei Hu, Nuo Xu, Jonathan Makris et autres

Aptasensor By utilizing the aptamers as the recognition elements, noble metal nanoparticle-based aptasensors offer a promising platform for rapid, cost-effective, and sensitive in situ detection of cell-secreted exosomes. More details can be found in article 2400002 by Hongjun Wang and co-workers.

Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection

Jingyu Sun, Wei Hu, Nuo Xu, Jonathan Makris et autres

Abstract Exosomes, secreted by various types of cells, play a crucial role in cell‐to‐cell communication by transporting essential molecular cargos that largely mirror the pathophysiological attributes of their parent cells. Increasing evidence has shown that exosomes emerge as the reliable early biomarkers …

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Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate

Weixiang He, Zelin Tian, Bingchen Dong, Yitong Cao et autres

Abstract Objective Benign prostatic hyperplasia (BPH) is common in elder men. The current study aims to identify differentially expressed genes (DEGs) in hyperplastic prostate and to explore the role of Nik related kinase (NRK) in BPH. Methods Four datasets including three bulk …

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The metabolic repression effect of carbon-ion radiotherapy in synchronous hormone-sensitive oligometastatic prostate cancer

Zhenshan Zhang, Yulei Pei, Wei Hu, Yushan Xue et autres

Background Metastatic prostate cancer (PCa) poses a significant public health concern. While radiation therapy (RT) is commonly utilized in the treatment of synchronous oligometastatic hormone sensitive prostate cancer (OM-HSPC), the occurrence of biochemical recurrence still remains. To deepen our understanding and optimize …

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SPR-Enhanced Au@Fe3O4 Nanozyme for the Detection of Hydroquinone

Bin Zhang, Xiaoming Wang, Wei Hu, Yiquan Liao et autres

Artificial nanozymes that are based on ferric oxides have drawn enormous attention due to their high stability, high efficiency, and low cost as compared with natural enzymes. Due to the unique optical plasmonic properties, gold nanoparticles (Au NPs) have been widely utilized …

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Depletion of the m6A demethylases FTO and ALKBH5 impairs growth and metastatic capacity through EMT phenotype change in clear cell renal cell carcinoma.

Wei Hu, Niklas Klümper, Doris H. Schmidt, Manuel Ritter et autres

BACKGROUND: A demethylases FTO and ALKBH5 on renal cell carcinoma (RCC) cell lines. METHODS: The epithelial-mesenchymal in vitro knockdowns of FTO and ALKBH5 induced by antisense oligonucleotides (LNA-GapmeR system) were established in RCC cell lines. Their effects on migration and proliferation were …

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Functional imaging-guided carbon ion irradiation with simultaneous integrated boost for localized prostate cancer: study protocol for a phase II randomized controlled clinical trial

Wei Hu, Ping Li, Zhengshan Hong, Xiaomao Guo et autres

BACKGROUND: Due to the physical dose distribution characteristic of "Bragg peak" and the biological effect as a kind of high linear energy transfer ray, heavy ion therapy has advantages over conventional photon therapy in both efficacy and safety. Based on the evidence …

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