Yinan Chen

Integrated Single‐Cell and Spatial Transcriptomics Reveal SERPINE1 as a Key Link Between Macro_SPP1 Macrophages and Stromal Remodeling in Gastric Cancer

Huangdao Yu, Jianhai Wu, Qingqi Hong, Hexin Lin et autres

Macrophage heterogeneity is increasingly recognized as an important feature of the gastric cancer tumor microenvironment, yet the macrophage states linked to poor outcome and the molecules connecting them to stromal remodeling remain incompletely defined. Here, we integrated single-cell RNA sequencing data from …

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Systemic remodeling of the glioblastoma microenvironment via plasma-induced vascular disruption and CSF-propelled oxidative therapy

Yinan Chen, Zuhao Luo, Chao Zhang, Shiqiang Hou et autres

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OGT accelerates diabetic retinopathy via O -GlcNAcylation of BAP1

Bairong Wang, Junteng Yao, Yuren Zhang, Meirong Li et autres

Abstract: Diabetic retinopathy (DR), a prevalent neurovascular complication of diabetes, is a leading cause of blindness in affected individuals. O-linked β-D-N-acetylglucosamine modification (O-GlcNAcylation), a unique form of post-translational modification regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase, plays a critical role in cellular …

GLP-1RAs: antidiabetic drug crossover—new hope for chronic inflammatory airway diseases

Yinan Chen, Yili Shen, Hui Shen, Zhicong Liu

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) represent a novel class of antidiabetic agents recognized not only for their efficacy in glycemic control and weight management but also for their distinctive cardiovascular benefits. Type 2 diabetes mellitus, a prevalent chronic metabolic disorder worldwide, frequently …

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Repetitive unidirectional spinal tactile stimulation engages microglial Bmal1 pathways to promote synaptic remodeling in the mPFC of adolescent VPA-exposed mice

Yinan Chen, Mingxin Hu, Wu Li, Juan Yu et autres

Synaptic abnormalities are hallmark pathological features of autism spectrum disorders (ASD), contributing to the behavioral impairments frequently observed in these neurodevelopmental conditions. Microglia, as the brain’s primary immune cells, are essential for synaptic refinement during adolescent development. Disrupted microglia-dependent synapse remodeling has …

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The energy structure function of fast radio bursts supports a stochastic origin model

Yinan Chen, Yongkun Zhang, Zi-Gao Dai

ABSTRACT The origin of fast radio bursts (FRBs) has remained a mystery up to now. There are two kinds of process invoking neutron stars as an origin of FRBs, namely inner-driven starquakes and outer-driven collisions with interstellar objects (ISOs). The former origin …

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Synthesis of SnO2-SnS2/SiO2 photonic-crystal-structure device for ultra-highly sensitive fluorescence sensing of NO2

Yanqiu Jiang, Lina Xie, Yinan Chen, Luyang Wang et autres

High-sensitivity fluorescent sensing of nitrogen dioxide (NO 2 ) gas at room temperature remains a critical challenge to be overcome currently. In this work, a thin-film device (TFD) based on photonic-crystal film (PCF) was synthesized for the fluorescence sensing of NO 2 …

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Temporal Summation of Repetitive Mechanical Stimulation in Patients with Painful Temporomandibular Joints and Healthy Controls

Xiaojing Xi, Ruofan Jin, Linfeng Yu, Jiali Shi et autres

Objective: The present study aimed to preliminarily explore the temporal summation (TS) response to repetitive mechanical stimulation in patients with temporomandibular joint disorders (TMD). Patients and Methods: Twenty patients with unilateral pain in the TMJ and 20 gender- and age-matched healthy controls …

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Receptor tyrosine kinase inhibitor tivozanib regulates cell state plasticity and restores MITF dependency in BRAF wild-type melanoma

Yanni Ma, Xuhui Ma, Mei-Ling Hao, Rui-xin Liu et autres

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UltraVideo: High-Quality UHD Video Dataset with Comprehensive Captions

Zhucun Xue, Jiangning Zhang, Teng Hu, Haoyang He et autres

The quality of the video dataset (image quality, resolution, and fine-grained caption) greatly influences the performance of the video generation model. The growing demand for video applications sets higher requirements for high-quality video generation models. For example, the generation of movie-level Ultra-High …

Effect of emergency surgery for distal femoral fracture using the locking compression plate: A retrospective analysis

Zhenqing Zhang, Yinan Chen, Zhenqiang Wang, Congliang Gao et autres

Objective To compare the effects of emergency surgery versus elective surgery using the locking compression plate (LCP) for the treatment of distal femoral fracture (DFF). Methods Sixty DFF patients admitted between June 2022 and October 2023 were analyzed retrospectively, including 32 cases …

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Performance evaluation of low-cost atmospheric particulate matter sensors and comparison of calibration methods

Yinan Chen, Shiguo Zhang, Kee Yuan, Jian Huang et autres

Low-cost particulate matter sensors can supplement limited data from air quality monitoring stations. Still, the accuracy of the measurement results is easily affected by environmental factors and often needs to be corrected before use. Previous studies have focused on single PM2.5 data …

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