Jian Huang

Multiomics Insights Into AL Amyloidosis

Zixuan Zhang, Ziru Huang, H. B. Tang, Xianrun Pan et autres

ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates. Recent …

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Charting the computational landscape of single-cell genetic perturbation

Yaozhi Zhang, Junyang Huang, Y Li, Tianyuan Liu et autres

BACKGROUND: Single-cell genetic perturbation screens are increasingly used to study gene function at single-cell resolution. However, their analysis remains difficult because available computational methods differ in assumptions, input requirements, and output definitions, which can complicate cross-study comparison and consistent tool selection. AIM …

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LCPBert: ProtBERT-based early-stage lung cancer prediction from T cell receptor beta sequences

Xin Yang, Yu Zhou, Zixuan Zhang, Huaichao Luo et autres

< 0.084). At an LCRI cutoff of 0.1465, LCPBert achieved 75% sensitivity and 70% specificity in discriminating lung cancer patients from healthy individuals. In a longitudinal cohort, LCRI elevation (Δ > 0.15) exceeding 0.30 after SBRT predicted distant metastasis (DM) in 75% …

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Multidimensional cfRNA response modeling identifies a 5-gene pair signature for high-robust pulmonary tuberculosis diagnosis

Changchun Wu, Huiyuan Qiao, Xianrun Pan, Hongyan Lin et autres

= 0.65) and radiological severity. Kappa analysis confirmed substantial diagnostic agreement (kappa = 0.42-0.56) between this signature and chest X-ray systems, with the signature providing high discriminative power in cases with ambiguous radiological findings. This cfRNA-based 5-gene pair signature establishes a robust …

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Association of serum high creatinine-to-albumin ratio with increased 1-year mortality in older patients following hip fracture surgery

PeiPei Jin, Jian Huang, Weian Yuan, Hao Wang et autres

Background Creatinine-to-albumin ratio (CAR) was associated with short-term and long-term prognosis in various clinical settings. However, the relation of CAR with prognosis in older patients with hip fracture remains unclear. Methods This retrospective study was performed in older patients undergoing hip fracture …

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Combined application of zinc oxide nanoparticles and melatonin improves growth, photosynthesis and redox homeostasis of cotton seedlings under salt stress

Zhiduo Dong, Fengli Jiao, X. Li, Jian Huang et autres

Salt stress severely limits the sustainability of cotton production. This study evaluated the synergistic potential of combined application of 100 mg L -1 zinc oxide nanoparticles (ZnO NPs) and 50 mg L -1 melatonin (MT) in mitigating salt induced injury in cotton …

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Development and Applications of Reactive Dye Inkjet Printing Ink

Jian Huang, Ziyang Lei, Yunli Wang, Li Ai et autres

ABSTRACT With the rapid advancement of digital inkjet printing technology, considerable attention has been directed toward the formulation design of inks. In this research, a comprehensive investigation was conducted into the physicochemical properties of reactive dye inks formulated with C.I. Reactive Blue …

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Supplementary Table S5 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Evaluate multiple model performance

Supplementary Figure S8 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Biology and Disease Annotation of Enriched CDR3-beta aaSeqs

Supplementary Table S2 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Identify lung cancer-enriched TCR sequences

Supplementary Table S1 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Clinical and TCR characteristics for LungTCR database

Supplementary Table S3 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Clinical and TCR characteristics for patients with indeterminate pulmonary nodules