Nailin Gao

Erianin induces apoptosis of thyroid cancer cells via TNF signaling pathway

Nailin Gao, Jihua Han, Xiang Ying Sun, Ju Yu et autres

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SOX18 meditates the resistance of Bmi1‐expressing cells to cetuximab in HNSCC

Caihua Zhang, Zhi Chen, Nailin Gao, Gan Xiong et autres

OBJECTIVE: Head and neck squamous cell carcinoma (HNSCC) is the most common type of malignancy in the head and neck region worldwide. The therapeutic strategies for HNSCC remain unsatisfying and limited. Here, we found a population of resistant Bmi1-expressing cells in the …

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The translational landscape of human vascular smooth muscle cells identifies novel short open reading frame-encoded peptide regulators for phenotype alteration

Kang V. Li, Bin Li, Dihua Zhang, Tailai Du et autres

AIMS: The plasticity of vascular smooth muscle cells (VSMCs) enables them to alter phenotypes under various physiological and pathological stimuli. The alteration of VSMC phenotype is a key step in vascular diseases, including atherosclerosis. Although the transcriptome shift during VSMC phenotype alteration …

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Artesunate exerts anti-prolactinoma activity by inhibiting mitochondrial metabolism and inducing apoptosis

Weiyu Zhang, Qiu Du, Piaopiao Bian, Zheng Xiao et autres

Background: Prolactinoma is the most common hormone-secreting pituitary adenoma. Dopamine receptor agonists (DAs) are effective in reducing prolactin levels and tumor mass, but some prolactinoma patients are resistant to DAs. Treating patients with DA-resistant prolactinoma is challenging. In this study, we examined …

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MEG3/MIR-376B-3P/HMGA2 axis is involved in pituitary tumor invasiveness

Dimin Zhu, Zheng Xiao, Zongming Wang, Bin Hu et autres

OBJECTIVE: To date, long noncoding RNAs (lncRNAs) have proven to function as key regulators in tumorigenesis. Among these lncRNAs, MEG3 displays low levels in various neoplasms and tumor cell lines. However, the regulatory mechanism of MEG3 and MIR-376B-3P, one of the microRNAs …

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Common tools for pituitary adenomas research: cell lines and primary cells

Ziyan Zhu, Weiwei Cui, Dimin Zhu, Nailin Gao et autres

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