Yong Xie

ABS1055 GB261 (CND261), A NOVEL CD20/CD3 T-CELL ENGAGER, HAS A DIFFERENTIATED SAFETY PROFILE AND POTENTIAL FOR DEVELOPMENT IN AUTOIMMUNE DISEASES

Yali Song, Zhijun Li, Jiawei Li, Zhaoxin Qian et autres

Background: B cells play an important role in the pathogenesis of autoimmune diseases, through the production of autoantibodies, secretion of inflammatory cytokines, antigen presentation and T cell co-stimulation. Anti-CD20 monoclonal antibodies have been used in the treatment of autoimmune disease, however incomplete …

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Analysis of the influence of two kinds of shell characteristics on the total weight and soft tissue weight of the clam Cyclina sinensis

Hongxing Ge, Yong Xie, Zhiguo Dong

To reveal the influence of shell traits between two shell colors on the body and soft tissue weight of the clam Cyclina sinensis , a total of 1000 individuals (500 with white shells and 500 with purple shells) were randomly selected to …

Giant cavernous hemangioma of liver complicated by Kasabach-Merritt syndrome

Yong Xie, Tianshi Lyu, Yi Zou, Jian Wang

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P1023 Clinical study of composite sophora colon-soluble capsules combined with vedolizumab in the treatment of Ulcerative Colitis

Xue Li, Yong Xie, Feng Tian

Abstract Background There are limited data on the treatment of ulcerative colitis(UC) with in combination with Chinese herbs.The aim of our study was to determine the effectivenes and safety of Vedolizumab combined with Composite Sophora Colon-soluble Capsules(CSCC) use in ulcerative colitis. Methods …

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SIGIRR Alleviates Intestinal Mucosal Damage in Severe Acute Pancreatitis via the TLR4 Signaling Pathway

Yang Liu, Feng Xi Zhou, Yanping Song, Shenglong Wei et autres

BACKGROUND & AIMS: Intestinal barrier dysfunction plays an important role in the development of severe acute pancreatitis (SAP). The aim of our study was to investigate the role of single immunoglobulin IL-1 receptor-related molecule (SIGIRR) and Toll-like receptor-4 (TLR4) signaling pathways in …

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Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p

Ming Chen, Yi Li, Mingming Zhang, Siliang Ge et autres

Regular physical activity is widely recognized for reducing the risk of various disorders, with skeletal muscles playing a key role by releasing biomolecules that benefit multiple organs and tissues. However, many individuals, particularly the elderly and those with clinical conditions, are unable …

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Relative Bioavailability of Sotorasib Following Administration as a Water Dispersion to Healthy Subjects and Compatibility With Enteral Administration

Panli Cardona, Marintan Spring, Jiemin Bao, Yong Xie et autres

Sotorasib is approved to be taken as 960 mg orally once daily (8 × 120-mg tablets) for the treatment of KRAS G12C-mutated nonsmall cell lung cancer. Dispersion of tablets in water could be an alternative method for patients who require a liquid …

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Artificial intelligence for geoscience: Progress, challenges, and perspectives

Tianjie Zhao, Sheng Wang, Chaojun Ouyang, Min Chen et autres

This paper explores the evolution of geoscientific inquiry, tracing the progression from traditional physics-based models to modern data-driven approaches facilitated by significant advancements in artificial intelligence (AI) and data collection techniques. Traditional models, which are grounded in physical and numerical frameworks, provide …

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Association between gut microbiota and acute pancreatitis: a bidirectional Mendelian randomization study

Feng Zhou, Yang Liu, Yanqing Shi, Nanzhen Wu et autres

BACKGROUND AND AIM: The dysbiosis of gut microbiota has been reported in acute pancreatitis. However, the direction and magnitude between host microbiota and pancreas remains to be established. This study investigated the association between gut microbiota and acute pancreatitis using Mendelian randomization …

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[Progressive necrotizing xanthogranuloma in both eyes: a case report].

Wei Yang, Hong‐Lin Chen, Rui Ren, Yong Xie et autres

A 55-year-old male patient presenting with 6 months of bilateral difficulty in eye opening was referred to the ophthalmology department. Upon examination, multiple yellowish tumor-like plaques and nodules were observed on the eyelids and chest of the patient, accompanied by keratitis and …

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Effect of edible bird's nest and N-acetylneuraminic acid on gut microbiota in different stages of pregnant rats fed with zinc deficient diet

Xiaodan Lu, Jingru Wu, Peixin Wang, Qunyan Fan et autres

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Edible bird's nest inhibits the inflammation and regulates the immunological balance of lung injury mice by SO2

Hongliang Zeng, Yeye Jian, Yong Xie, Qunyan Fan et autres

Abstract The purpose was to investigate effect of edible bird's nest (EBN) on the immunological properties of mice with lung injury induced by sulfur dioxide (SO2). In mice, SO2 exposure caused symptoms that included a cough, tiredness, and weight loss. Administering EBN …

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