Tong Wu

The mechanistic nexus between microplastics and chronic liver disease: A review of current evidence

Shiyun Pu, Changyu Ren, Jiao Liu, Jingyi Zhang et autres

The progression of chronic liver disease results in severe complications. However, current treatment options remain limited. Research indicates that environmental pollutants, such as microplastics (MPs), pose a threat to the progression of chronic liver disease and represent a substantial challenge to human …

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The relationship between high-sensitivity C-reactive protein levels and asthma in middle-aged and elderly Chinese population: a cross-sectional study based on China Health and Retirement Longitudinal Study (CHARLS)

Dongfang Ding, Tong Wu, Liwen Zhai, Shuixiang Deng et autres

Background Systemic inflammation has been increasingly recognized as a potential contributor to asthma pathogenesis, particularly in middle-aged and older populations.Objective This study aimed to examine the association between serum High-sensitivity C-reactive protein (hs-CRP) levels and asthma in middle-aged and older adults in …

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The dual roles of exosomes in prostate cancer: mechanisms in tumorigenesis and avenues for clinical translation

Mingyun Yu, Dan Zhou, Huijie Wei, Tong Wu et autres

Prostate cancer (PCa) management remains challenged by tumor heterogeneity, unpredictable progression, and limitations in early detection, driving demand for innovative biological insights. As pivotal mediators of intercellular communication, exosomes exhibit dualistic roles in PCa pathogenesis and therapy. While acting as 'foes' by …

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One-step fabrication of adhesive, stable, and antioxidant polylipoic acid hydrogels for wound healing

Chunyue Zhao, Enchang Liu, Fangzheng Zhao, Tong Wu et autres

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OTUD1 inhibits osteoclast differentiation and osteoclastic bone loss through deubiquitinating and stabilizing PRDX1

Xiaoyu Sun, Tong Wu, Shuhong Chen, Zheyu Zhao et autres

Our findings provided the first evidence that OTUD1 suppressed osteoclastogenesis by deubiquitinating PRDX1 and maintaining its stability, thereby offering a promising therapeutic approach for osteoclast-dependent bone diseases.

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Will climate change inevitably disrupt the cryospheric budget dynamics of the Third Pole?

Lingxiao Ying, Hua Zheng, Xuan Huang, Tong Wu et autres

Abstract The global cryosphere is retreating under ongoing climate change. The Third Pole (TP) of the Earth, which serves as a critical water source for two billion people, is also experiencing this decline. However, the interplay between rising temperatures and increasing precipitation …

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Development and validation of a UPLC–MS/MS method for simultaneous quantification of polymyxins and caspofungin in human plasma for therapeutic drug monitoring

Tong Wu, Libin Pu, Wenqing Liu, Yinliang Bai et autres

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Nucleoside-Stabilized Stimuli-Responsive Lipoic Acid Supramolecular Hydrogel: An Efficacious Antioxidant and Antibacterial Platform for Chronic Diabetic Wound Repair

Chunyue Zhao, Tong Wu, Enchang Liu, Fangzheng Zhao et autres

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Ubiquitin‐Proteasome System in Periodontitis: Mechanisms and Clinical Implications

Yilin Ma, Ru Jia, Shuhong Chen, Jun Ma et autres

The progression of periodontitis, a bacteria-driven inflammatory and bone-destructive disease, involves myriad cellular and molecular mechanisms. Protein regulation significantly influences the pathogenesis and management of periodontitis. However, research regarding its regulatory role in periodontitis remains relatively limited. The ubiquitin-proteasome system (UPS), which …

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Long-Term Efficacy and Safety of Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed or Resistant Ph+ Acute B Lymphoblastic Leukemia That Cannot Get MRD- Remission after Multi-Line Treatment

Yanzhi Song, Erhui Yuan, Qi Wang, Zhanxiang Liu et autres

Background The prognosis of PH positive (+) acute B lymphoblastic leukemia (B-ALL) has greatly improved after chemotherapy combined with tyrosine kinase inhibitors (TKIs). However, there are still a great many patients who get complete remission (CR), but minimal residue disease (MRD) cannot …

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Clinical Analysis of CAR-T Cell Therapy in Patients with Relapsed Acute B-Lymphoblastic Leukemia after Second Allogeneic Hematopoietic Stem Cell Transplantation

Yan Hong, Bofeng Li, Ruyue Zheng, Yuehui Lin et autres

**Background:** Patients with relapsed acute B-lymphoblastic leukemia (B-ALL) after a second allogeneic hematopoietic stem cell transplantation (allo-HSCT) have limited treatment options and low remission rates. This study explores the efficacy of CAR-T cell immunotherapy in these patients. **Objective:** To observe the efficacy …

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Effects of endogenous and exogenous glucose dependent insulinotropic polypeptide on blood pressure, heart rate, gastric emptying and blood glucose responses to oral glucose in healthy older people

Ryan J. Jalleh, Seva Hatzinikolas, A.C. Slavotinek, Md. Kamruzzaman et autres

International audience

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