Wenqing Liu

The Immunomodulatory Effects of Mannan on the Fungicidal Activity of Macrophages Against Candidozyma auris Bloodstream Infection Associated with the GPCR-PI3K-NF-κB Signaling Pathway

Rong Wang, Wenqing Liu, Xiaoyu Peng, Shu Gong et autres

Candidozyma auris is an emerging multidrug-resistant fungal pathogen, which causes high mortality and nosocomial outbreaks worldwide. Macrophages are key innate immune cells that clear fungi through phagocytosis, reactive oxygen species, and cytokine secretion. Mannan, a major fungal cell wall polysaccharide, has immunomodulatory …

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Rethinking the immune recognition of cell walls in human fungal pathogens: Mechanisms, controversies and translational significance

Rong Wang, Xiaoyu Peng, Wenqing Liu, Zhangyong Song et autres

Fungal cell wall polysaccharides – such as β-glucans, chitin, and mannans – are key immunogenic structures recognized by Toll-like receptors and C-type lectin receptors on innate immune cells, initiating phagocytosis, cytokine production, and antigen presentation, and shaping downstream adaptive immunity. CD4+ T …

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Subcutaneous transplantation of lung organoids ameliorates vascular dementia via the IGFBP7-Ago2 mediated lung-brain axis

Qihang Luo, Jie Yang, Jiabao Huang, Nanhe Lin et autres

Vascular dementia (VaD), whose leading cause is chronic cerebral hypoperfusion (CCH), currently has no approved effective disease-modifying therapies. The lung-brain axis mediates crosstalk between the lung and the nervous system, yet the specific mediators underlying its role in VaD remain unclear. This …

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Bibliometric and scientometric analysis of late-onset hypogonadism in the past two decades: knowledge mapping and research trends

Peng Ge, He Zhang, Wenqing Liu, Xiaoyang Wang et autres

Background: Late-onset hypogonadism (LOH) is a clinical biochemical and clinical syndrome characterized by testosterone decline in association with increasing age. LOH prevalence is expected to increase further given the rapidly aging global population, and become a significant health burden. The present study …

CRISPR-free RNA base editing mediated PTC-readthrough restores hearing in mice with Otof nonsense mutation

Hanxiao Sun, Teng Qi, Wenqing Liu, Rui Guo et autres

The gene therapy achieved by AAV-mediated otoferlin-overexpression is an effective therapeutic strategy for congenital deafness. However, achieving its physiological and endogenous patterns of expression remains challenging. Here, we generate the homologous mutation Otof c.1315 C > T (p.R439*), equivalent to OTOF c.1273 …

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Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning

Qiangqiang Cheng, Wenqing Liu, Yao Li, Shuyuan Xu et autres

Research indicates that midbrain dopaminergic neurons encode reward prediction error (RPE) signals involved in positive reinforcement learning. However, studies on dopamine's role in negative reinforcement learning (NRL) are scarce. Learning to escape aversive stimuli is vital for survival and may differ significantly …

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Melatonin suppresses cancer cell proliferation, DNA repair and expression of the oncogene TRIP13

Wenqing Liu, Ans M. M. van Pelt, Geert Hamer

Non-small cell lung cancer (NSCLC) continues to be a global health challenge, with limited treatment options and a high mortality rate. We recently found that lung cancer cells that express more genes that are typically restricted to the germline (germ cell cancer …

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The association of the systemic inflammation response index with the prognosis of primary retroperitoneal liposarcoma after surgical resection

Weida Chen, Wenqing Liu, Chengli Miao

Primary retroperitoneal liposarcoma (PRPLS) is a rare malignancy with a high risk of recurrence and poor prognosis. To evaluate the prognostic value of the systemic inflammation response index (SIRI) in patients with PRPLS undergoing curative-intent surgical resection and to compare its predictive …

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Cross-neutralization effect of the third dose of inactivated COVID-19 vaccine against the SARS-CoV-2 variants

Yuqing Li, Jia He, Wenqing Liu, Runjie Qi et autres

BACKGROUND: The ongoing emergence of SARS-CoV-2 variants has raised concerns about the breadth of the immune response provided by existing vaccines. RESEARCH DESIGN AND METHODS: In this study, participants aged 18-75 years with no prior COVID-19 infection or vaccination history were enrolled …

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Quercetin inhibits the cAMP/PKA/CREB/glycolysis axis to exert anti-acute lymphoblastic leukemia effects

Qiuling Ma, Wenqing Liu, Yajing Su, Man Zhang et autres

Acute lymphoblastic leukemia (ALL), an aggressive hematologic malignancy with high incidence and treatment resistance, demands novel therapeutic approaches. Enhanced glycolysis is a hallmark of metabolic reprogramming in ALL. Quercetin (Que) demonstrates broad antitumor effects by inhibiting glycolysis and cell proliferation. Previous studies …

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Emerging frontiers in cHCC-CCA organoid models: bridging stem cell innovation to precision oncology

Juntao Sun, Wenqing Liu, Ye Gao, Yuehuan Liu

Abstract Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare and complex liver malignancy characterized by diverse clinical features and unfavorable therapeutic responses. The utilization of organoid technology, a nascent research methodology, demonstrates considerable promise in replicating the pathophysiological aspects of cHCC-CCA, facilitating disease modeling …

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The role of iron competition in the antagonistic action of Metschnikowia pulcherrima against three major pathogenic fungi on postharvest citrus fruit

Shupei Wang, Chenshu Wang, Wenqing Liu, Fangxue Hang et autres

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