Xiaoping Zhao

DNAzyme-Triggered Dual-MOF Ratiometric Electrochemical platform for Ultrasensitive Detection of Copper Ion

Peng Ma, Pengcheng Liu, Bohao Zhang, Qingyin Zheng et autres

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Cascade signal amplification in hierarchical MOFzymes for revolutionizing electrochemical diagnostics of African swine fever virus

Xiaoping Zhao, Lingjie Meng, Mingzhu Wang, Hong Tian et autres

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A novel anticancer natural product SP09 selectively targets KRAS-mutant NSCLC through LKB1/AMPK/mTOR modulation: implications for novel therapeutic development

Peng Yue, Chi Tin Hon, Xiaoping Zhao, Jiayi Sun et autres

KRAS -mutant non-small cell lung cancer (NSCLC) remains a major therapeutic challenge due to the paucity of effective targeted agents. Although covalent KRAS^G12C inhibitorsi such as sotorasib and adagrasib have demonstrated clinical activity, pooled analyses indicate only modest response rates and short …

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High-fidelity AaCas12bMax enables the development of an engineered T cell therapy with enhanced safety and functional fitness

Jingwei Sun, Sheng Yao, Hongwei Zhang, Jingman Wang et autres

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Deep Learning for Automatic T-Staging Prediction of Laryngeal Cancer Using CT Scan and Radiology Report

Xiaoping Zhao, Yu‐Li Su, J. Wang, Zhenyu Ji et autres

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Multi-Model Secure Redundant Storage for IoT Data Using Random Forests, Deep Neural Networks, and Adaptive Particle Swarm Optimization

Shenzhang Li, Zhenwei Geng, Wenwei Su, Haoyu Ning et autres

With the increasing deployment of IoT systems, secure and efficient data storage has become a critical challenge. This paper proposes a multi-model secure redundant storage approach for IoT data by integrating Random Forest (RF), Deep Neural Network (DNN), and Adaptive Particle Swarm …

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Effects of exogenous sucrose on root nitrogen uptake in apple at sub-low root-zone temperature

Xiaoping Zhao, Hanyu Liu, Lijie Li, Deguo Lyu

Sub-low soil temperature in spring can cause stress to the apple roots, reducing root function and inhibiting nitrogen (N) uptake. Exogenous sucrose can protect plants from low temperature stress, however, the role of sucrose in regulating the N uptake in apple roots …

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National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021

Songjun Tu, Xiaolu Huang, Xiaoxuan Fan, Victor Wei Zhang et autres

BACKGROUND: Primary central nervous system (CNS) cancers remain a leading global cause of mortality and morbidity. However, comparative analyses between China and global regions during the 1990-2021 period remain lacking in the existing literature.Leveraging data from the Global Burden of Disease Study …

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Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis

Zesheng Xu, Man Li, Lin Liu, Shu-Jing Wu et autres

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Coaxial 3D Printing of Blood Vessels for Monitoring Monocyte‐Endothelium Interactions and Drug Discovery

Jiawen Zou, Zeming Gu, Xutao Ge, Yi Wang et autres

Monocyte adhesion to the vascular endothelium is recognized as an early feature of atherosclerosis, involving various cytokines and pathological events. Current assays for evaluating monocyte-endothelium interactions typically rely on 2D co-culture models, which is hard to accurately represent the spatiotemporal characteristics of …

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[Studies on the best production mode of traditional Chinese medicine driven by artificial intelligence and its engineering application].

Zheng Li, Ningtao Cheng, Xiaoping Zhao, Yi Tao et autres

The traditional Chinese medicine(TCM) industry is a crucial part of China's pharmaceutical sector and plays a strategic role in ensuring public health and promoting economic and social development. In response to the practical demand for high-quality development of the TCM industry, this …

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Abstract 865: Engineering a next-generation dual-knockout TIL product with AaCas12b nuclease editing

Jingwei Sun, Sheng Yao, Hongwei Zhang, Zhu Xi et autres

Advancing cellular therapies, particularly allogeneic and functionally enhanced treatments using gene editing technologies, necessitates rigorous safety and quality assessments to ensure clinical success. Among CRISPR nucleases, Cas12b—a type V CRISPR enzyme—stands out for its high editing fidelity, owing to its stringent mismatch …

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