Xiaolu Huang

Global research trends in the tumor microenvironment of glioma: insights from bibliometric analysis

Xiaolu Huang, Shifan Tu, Xiaoxuan Fan, Yi Zhang et autres

Abstract Objective This study employs visual mapping and bibliometric analysis to synthesize valuable information from research on the glioma tumor microenvironment (TME) over the past decade, aiming to identify research hotspots and trends in this field. Methods We retrieved all relevant literature …

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Integrated Transcriptomic and Metabolomic Analyses Reveal the Mechanism by Which 5-Methoxyindole Enhances Sesquiterpenoids Production in Atractylodes chinensis Hairy Roots

Beibei Shi, Xiaolu Huang, Yu Xiao, Ying Li et autres

Atractylodes chinensis (DC.) Koidz is a pharmacologically significant medicinal plant that produces various bioactive metabolites, including β-eudesmol, which largely determines its medicinal quality and clinical efficacy. Treatment of A. chinensis hairy roots with 5-methoxyindole (5-MI), a chemical homolog of melatonin, revealed that …

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Protocol: Comparative efficacy of 2 mL vs. 5 mL 0.375% ropivacaine in subparaneural upper trunk brachial plexus block for postoperative analgesia after arthroscopic shoulder surgery—a randomized noninferiority trial

Jie Lou, Yu Zhang, J K Chen, Shunli Diao et autres

Introduction: Interscalene brachial plexus block (ISB) is the first-line analgesic technique for arthroscopic shoulder surgery, but it is associated with a > 90% incidence of ipsilateral hemidiaphragmatic paresis (HDP), which severely limits its application in patients with preexisting pulmonary dysfunction. All currently …

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Serum uric acid in systemic lupus erythematosus with preserved renal function: a cross-sectional and longitudinal analysis

Xiaolu Huang, Hongpu Chen, Yulin Wang, 林福安

Objective: To evaluate the association of serum uric acid (SUA) with established lupus nephritis (LN) and to explore its prospective association with incident LN in systemic lupus erythematosus (SLE) patients presenting with preserved renal function. Methods: We enrolled 97 SLE patients with …

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Morphological, structural, and physicochemical properties of starch isolated from bulbs of Cardiocrinum giganteum (Wall.) Makino

Rongchen Li, Bowen Li, Xiaolu Huang, Liyun Huang et autres

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The Role of Keratin in the Mechanisms of Kidney Diseases

Shitian Che, Xiaolu Huang, Shuxiang Yan, Baiyu Feng et autres

Kidney disease remains a leading cause of global mortality, with its prevalence continuing to rise. Despite advances in understanding glomerular pathologies and acute kidney injury, the progression to irreversible renal failure and its associated systemic complications represent a major unresolved challenge. Keratin, …

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Explainable AI for post-hoc and pseudo-post-hoc predictive maintenance of governor valve actuators

Jun Hu Tang, Yang Liu, Xiaolu Huang, Zhanpeng Jiang et autres

The governor valve actuator (GVA), as the actuating mechanism of the steam turbine governing system, directly impacts production safety and economic efficiency. Its highly coupled nature leads to high-dimensional operational data, complex fault modes, and inherent opacity in diagnostic algorithms, posing significant …

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Function and defense mechanisms of wheat 14-3-3 protein TaGF14a in stripe rust resistance

Beibei Shi, Xiaolu Huang, Zhenqing Bai, Jiawen Wu et autres

BACKGROUND: As critical regulatory elements in plant signaling transduction, 14-3-3 proteins orchestrate defense responses against biotic and abiotic stresses. This study investigates the functional role of TaGF14a in wheat's immune response to Puccinia striiformis f. sp. tritici (Pst), providing novel genetic insights …

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A Novel Evolutionary Structural Topology Optimization Method Based on Load Path Theory and Element Bearing Capacity

Jianchang Hou, Zhanpeng Jiang, Xiaolu Huang, Hui Lian et autres

Structural topology optimization is a crucial approach for achieving lightweight design. An effective topology optimization algorithm must strike a balance between the objective functions, constraints, and design variables, which essentially reflects the symmetry and tradeoff between the objective and constraints. In this …

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Trogocytosis at crossroads: Navigating the duality in tumor-immune cell interactions

Xin Ling Yang, Xiaolu Huang, Wei Zhang, Ousheng Liu et autres

Trogocytosis, derived from the Greek “trogo-,” meaning “nibble,” is a cellular process in which one cell extracts membrane fragments and surface molecules from another, modulating the functions of both donor and recipient cells. In tumor immunology, trogocytosis between immune cells and tumor …

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National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021

Songjun Tu, Xiaolu Huang, Xiaoxuan Fan, Victor Wei Zhang et autres

BACKGROUND: Primary central nervous system (CNS) cancers remain a leading global cause of mortality and morbidity. However, comparative analyses between China and global regions during the 1990-2021 period remain lacking in the existing literature.Leveraging data from the Global Burden of Disease Study …

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Assembly and comparative analysis of the complete mitochondrial genome of Cardiocrinum giganteum: a primitive Liliaceae group with significant scientific research value

Zhiheng Zhao, Liyun Huang, Xiaolu Huang, Jianming Liao et autres

BACKGROUND : Cardiocrinum giganteum, belonging to genus Cardiocrinum of family Liliaceae, is a genus endemic to East Asia and is considered one of the more primitive groups within the Liliaceae family. C. giganteum is the largest one among all the lily species …

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