Qiubo Lv

Real-world safety and effectiveness of fuzuloparib in patients with ovarian cancer: A prospective multicenter study

Bowen Huang, Jie Jiang, Mingqian Lu, Yingjie Yang et autres

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Modified paravaginal repair combined with sacrospinous ligament suspension for pelvic organ prolapse: a randomized controlled study

Hongpei Li, Ye Li, Guihua Shen, Qiubo Lv et autres

BACKGROUND: Native tissue repair surgery for pelvic organ prolapse is associated with a high recurrence rate, and accumulating evidence has highlighted adverse events related to mesh use. This study aimed to assess the efficacy and safety of a modified paravaginal repair technique …

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Comparing the KangDuo Surgical Robot-01 and da Vinci Xi system for endometrial cancer surgery: a multi-center, randomized, parallel-controlled, noninferiority trial

Yuan Li, Qiubo Lv, Junying Tang, Ming Du et autres

BACKGROUND: The outcomes of patients who undergo surgical staging for endometrial cancer using the KangDuo Surgical Robot-01 (KD-SR-01) have not been compared with those of patients who undergo this procedure using the da Vinci Xi system. The aim of this study is …

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Safety and effectiveness of fuzuloparib in patients with ovarian cancer: A nationwide, multicenter, prospective real-world study.

Qinglei Gao, Jie Jiang, Mingqian Lu, Zhe Guo et autres

5572 Background: Fuzuloparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is approved in China for the treatment of platinum-sensitive recurrent (PSR) ovarian cancer (OC) and for maintenance therapy in newly diagnosed advanced and PSR OC. This study aims to evaluate the safety and …

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Nimotuzumab combined with chemotherapy in the first-line treatment for patients with stage IVB, recurrent or persistent cervical squamous cell carcinoma: A multi-center, randomized, double-blind, and controlled study.

Jusheng An, Jing Wang, Chunyan Wang, Qi Zhou et autres

5510 Background: Stage IVb, recurrent or persistent cervical cancer patients have limited treatment options and poor survival prognosis. Additionally, 70-90% of cervical cancers have overexpression of EGFR (epidermal growth factor receptor), a promising therapeutic target. Nimotuzumab (nimo), an EGFR antibody, 95% humanization …

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The potential for de-escalation radical surgery in women with stage IB2 cervical cancer (FIGO 2018): a multi-institutional experience of 63,926 cases over a 14-year period in China

Jiaxin Fu, Pengfei Li, Jilong Yao, Zhonghai Wang et autres

OBJECTIVE: To compare the long-term survival outcomes, recurrence patterns and morbidity of type B and type C radical hysterectomy (RH) for stage IB2 cervical cancer (FIGO 2018). METHODS: Based on FOUR-C database, patients who underwent type B or C RH in 47 …

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Secondary Cytoreductive Surgery for Ovarian Cancer With Second Platinum‐Sensitive Recurrence: A Multicentre Retrospective Cohort Study

Yuxi Zhao, Zhihao Jiang, Tao Guo, Meiting Cao et autres

OBJECTIVE: To compare survival outcomes between patients with ovarian cancer with platinum-sensitive recurrence (PSR) who underwent secondary cytoreductive surgery (SCS) at the first recurrence and those who underwent SCS at the second recurrence. DESIGN: Multicentre cohort study. SETTING: Data were retrospectively collected …

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Analysis of feasibility, effectiveness and safety of transvaginal natural orifice transluminal endoscopic surgery(vNOTES) of ectopic pregnancy: a retrospective study

Shuo Zhang, Dan Zhou, Jinbowen Yan, Bo Zhang et autres

BACKGROUND: vNOTES has been documented as a viable approach for conducting benign gynecologic surgery; however, its application in ectopic pregnancy cases remains relatively scarce. The principal objective of this investigation was to assess the practicability, effectiveness, and safety of vNOTES in surgical …

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Clinical analysis of molecular typing of 146 cases of endometrial carcinoma

Bo Zhang, Dan Zhou, Shuo Zhang, Jinbowen Yan et autres

Objective: To investigate the application of TCGA molecular typing in endometrial carcinoma, compare the relationship between molecular typing and clinicopathologic features, and provide a new idea for individual treatment of patients. Methods: A total of 146 EC patients who underwent surgical treatment …

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Corrigendum to “CDYL loss promotes cervical cancer aggression by increasing PD-L1 expression via the suppression of IRF2BP2 transcription” [Transl Oncol. 2024 Sep;47:102038 /PMID: 38991463]

Ying Jun Cui, Yuxi Zhao, Guihua Shen, Qiubo Lv et autres

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Assessing High-Risk Pregnancy Impact on Premature Infant Brain Development Using Synthetic MRI and Doppler Ultrasound

Qiubo Lv

Motivation: To explore high-risk pregnancy effects on premature infant brain development. Conditions like preeclampsia, gestational diabetes, and thyroid dysfunction can profoundly impact fetal brain development. Goal(s): To evaluate the correlation between synthetic MRI and Doppler ultrasound in assessing brain development in high-risk …

CDYL loss promotes cervical cancer aggression by increasing PD-L1 expression via the suppression of IRF2BP2 transcription

Ying Jun Cui, Yuxi Zhao, Guihua Shen, Qiubo Lv et autres

BACKGROUND: Recurrent or metastatic cervical cancer have an extremely low 5-year survival rates about 17% due to limited therapeutic options. CDYL plays a critical role in multiple cancer development, as an oncogene or tumor suppressor in a context-dependent manner. However, the role …

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