Seon Min Kim

Resolving the subcellular redox landscape of Coenzyme Q

Tae Ha Kim, Chi Thi Ngoc Nguyen, Dahee Jang, Sae Bom Lee et autres

Coenzyme Q (CoQ) is an essential electron carrier and lipophilic antioxidant whose biological functions depend on its redox state. However, accurate measurement of reduced and oxidized CoQ is hindered by rapid ex vivo oxidation during sample preparation and analysis. Here, we develop …

kr, jp, Éthiopie, de, ca (code pays fourni par la source)

Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress

Min‐Keun Lee, Seon Min Kim, Sanghyuk Lee, Jin Ho Yang et autres

Abstract Aberrant protein acylation by reactive acyl species (RAS)—termed carbon stress—is a major driver of aging and metabolic disease. While enzymatic deacylases such as sirtuins counteract aberrant acylation, whether endogenous metabolites can directly neutralize RAS remains unclear. Here, we report that nucleophilic …

kr, Éthiopie, us (code pays fourni par la source)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min et autres

Elevated liver stiffness is closely associated with morbidity and mortality in metabolic dysfunction-associated steatotic liver disease (MASLD). However, the contribution of increased stiffness to impaired liver function is poorly understood. Here, we demonstrate that hepatic cholesterol levels are determined by the stiffness …

kr, Éthiopie (code pays fourni par la source)

Targeting FSP1 triggers ferroptosis in lung cancer

Katherine Wu, Alec Vaughan, Jozef P. Bossowski, Yuan Hao et autres

Emerging evidence indicates that cancer cells are susceptible to ferroptosis, a form of cell death that is triggered by uncontrolled lipid peroxidation1–3. Despite broad enthusiasm about harnessing ferroptosis as a novel anti-cancer strategy, whether ferroptosis is a barrier to tumorigenesis and can …

us, kr, de (code pays fourni par la source)

Targeting FSP1 triggers ferroptosis in lung cancer

Katherine Wu, Alec Vaughan, Jozef P. Bossowski, Yuan Hao et autres

ABSTRACT Pre-clinical and clinical studies have demonstrated how dietary antioxidants or mutations activating antioxidant metabolism promote cancer, highlighting a central role oxidative stress in tumorigenesis. However, it is unclear if oxidative stress ultimately increases to a point of cell death. Emerging evidence …

us, kr, de (code pays fourni par la source)

Dual-Isotope Kinetic LC-MS/MS Enables Redox-Preserving Coenzyme Q Profiling for Ferroptosis and Biomarker Discovery

Tae Ha Kim, Chi Thi Ngoc Nguyen, Seon Min Kim, Yun Pyo Kang et autres

kr (code pays fourni par la source)

Selective Elimination of Genetic Variants of Human Embryonic Stem Cells from High Vulnerability to Ferroptosis

Yun-Jeong Kim, Seon Min Kim, Young-Hyun Go, Han Sun Kim et autres

kr (code pays fourni par la source)

Selective Elimination of Genetic Variants of Human Embryonic Stem Cells from High Vulnerability to Ferroptosis

Yun-Jeong Kim, Seon Min Kim, Young-Hyun Go, Han Sun Kim et autres

kr (code pays fourni par la source)

Selective Elimination of Genetic Variants of Human Embryonic Stem Cells from High Vulnerability to Ferroptosis

Yun-Jeong Kim, Seon Min Kim, Young-Hyun Go, Han Sun Kim et autres

Despite the great promise of human pluripotent stem cell (hPSC)-based cell therapy, safety concerns arise from genetic aberrations during in vitro culture, due to their uncertain consequences. Notably, these genetic aberrations confer a survival trait known as "culture-adaptation", allowing aberrant hPSCs to …

Éthiopie, kr (code pays fourni par la source)

Robust Determination of Coenzyme Q10 Redox Status Using Two Isotope-Labeled Internal Standards

Yun Pyo Kang, Tae Ha Kim, Chi Thi Ngoc Nguyen, Seon Min Kim et autres

kr (code pays fourni par la source)

Mass spectrometry-based approaches to explore metabolism regulating ferroptosis

Chi Thi Ngoc Nguyen, Seon Min Kim, Yun Pyo Kang

Ferroptosis is a type of programmed cell death distinct from apoptosis or necroptosis. Ferroptosis is well characterized by an iron-dependent accumulation of lipid peroxides and disruption of cellular membrane integrity. Many metabolic alterations can prevent or accelerate ferroptosis induction. Recent advances in …

kr (code pays fourni par la source)

Induction of cancer-related microRNA expression profiling using excretory-secretory products of Clonorchis sinensis

Jhang Ho Pak, In Ki Kim, Seon Min Kim, Sejung Maeng et autres

kr (code pays fourni par la source)