Fiona O’Neill

Cold Atmospheric Plasma as a Potential Disease-Modifying Therapy for Osteoarthritis

Vinay Kumar, Fiona O’Neill, Emma J. Murphy, Declan M. Devine et autres

Osteoarthritis (OA) is a disabling joint disease characterised by cartilage degradation, synovial inflammation, and subchondral bone remodelling. Furthermore, catabolic inflammatory processes as well as dysregulated cellular signalling and oxidative stress are central to OA pathogenesis. Despite its growing global burden, currently available …

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Cold Plasma Deposition of Tobramycin as an Approach to Localized Antibiotic Delivery to Combat Biofilm Formation

Beatrice Olayiwola, Fiona O’Neill, Chloe Frewen, Darren F. Kavanagh et autres

Hospital-acquired infections (HAIs) remain a significant factor in hospitals, with implant surfaces often becoming contaminated by highly resistant strains of bacteria. Recent studies have shown that electrical plasma discharges can reduce bacterial load on surfaces, and this approach may help augment traditional …

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Recent Developments in the Use of Plasma in Medical Applications

Fiona O’Neill, Liam O’Neill, Paula Bourke

A detailed review of the scientific literature was undertaken to examine the most recent developments in plasma processing in the field of medicine. The first part of the review includes a detailed breakdown of the different types of coatings that can be …

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Molecular species determination of cyathostomins from horses in Ireland

Orla Byrne, Disha Gangotia, John W Crowley, Annetta Zintl et autres

Cyathostomins are globally important equine parasites, responsible for both chronic and acute pathogenic effects. The occurrence of mixed infections with numerous cyathostomin species hinders our understanding of parasite epidemiology, host-parasite dynamics, and species pathogenicity. There have been few studies of cyathostomin species …

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Recent Developments in the use of Plasma for Therapeutic Applications

Fiona O’Neill, Liam O’Neill, Paula Bourke

A detailed review of the scientific literature was undertaken to examine the most recent developments in plasma processing in the field of medicine. The first part of the review includes a detailed breakdown of the different types of coatings that can be …

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Feasibility and Efficacy of Cold Plasma for Direct Deposition of Topotecan

Beatriz Pinheiro Lopes, Fiona O’Neill, Liam O’Neill, Paula Bourke et autres

Cold plasma therapy is emerging as an innovative modality, with the potential to exhibit synergistic effects when combined with chemotherapeutic agents. A new plasma-assisted local delivery of oncology drugs was developed to mediate the drug delivery and possibly enhance the drug uptake …

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Molecular Species Determination of Cyathostomins from Horses in Ireland

Orla Byrne, Disha Gangotia, John W Crowley, Annetta Zintl et autres

Abstract Cyathostomins are globally important equine parasites, responsible for both chronic and acute pathogenic effects. The occurrence of mixed infections with numerous cyathostomin species hinders our understanding of parasite epidemiology, host-parasite dynamics and species pathogenicity. There have been few studies of cyathostomin …

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The Efficacy of Cold Atmospheric Plasma Deposited Antibiotics on Titanium Surfaces and Their Elution Liquids Against Staphylococcus aureus Growth Over Time

Beatrice Olayiwola, Fiona O’Neill, Darren F. Kavanagh, Liam O’Neill et autres

Cold atmospheric plasma (CAP) was used to deposit antibiotics, penicillin, and ciprofloxacin, separately onto titanium coupons. The antibiotic coating parameters were varied using a design of experiment software which factored in plasma power, bacterial and antibiotic load. The antimicrobial activity of the …

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Effects of Direct and Indirect Treatment of Human Cells with Cold Atmospheric Plasma Devices

Cian D. Madigan, Fiona O’Neill, Denis O’Sullivan, Darren F. Kavanagh et autres

An in vitro study was conducted to compare the interaction of two cold atmospheric plasma devices on mammalian cells.The two devices were powered by the same FDA-cleared radio frequency power supply, but operated under different power regimes-direct and afterglow.Cells were plasma-treated for …

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Resistance of Brain Tumours to Small-Molecule-Targeted Therapies: Lessons from Various Cancer Types

Fiona O’Neill

Comparison of single CT scan assessment of bone mineral density, vascular calcification and fat mass with standard clinical measurements in renal transplant subjects: the ABC HeART study

Sinead M. Kinsella, Kevin P. Murphy, Micheál A. Breen, Siobhan B O’Neill et autres

BACKGROUND: Despite limitations of routine methods, Clinical Practice Guidelines support the assessment of bone mineral density (BMD) and vascular calcification in renal transplant recipients. Changes in fat mass also occur post-transplantation, although they are traditionally difficult to measure accurately. We report the …

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Non-contrast CT at comparable dose to an abdominal radiograph in patients with acute renal colic; impact of iterative reconstruction on image quality and diagnostic performance

Patrick D. McLaughlin, Kevin P. Murphy, Sara A. Hayes, Kathleen Carey et autres

OBJECTIVES: The aim was to assess the performance of low-dose non-contrast CT of the urinary tract (LD-CT) acquired at radiation exposures close to that of abdominal radiography using adaptive statistical iterative reconstruction (ASiR). METHODS: Thirty-three patients with clinically suspected renal colic were …

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