Accès ouvert
2026
article
OpenAlex
Shuang Sun, Keke Li, Xiaoou Sun, Ruibing Tian et autres
Cilia are microtubule-based cellular protrusions critical for cell signaling and motility. The ciliary transition zone connects axonemal microtubules to the ciliary membrane and functions as a gatekeeper by regulating selective targeting and sorting of proteins. However, the molecular mechanisms underlying its assembly …
cn
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Accès ouvert
2025
article
OpenAlex
Li-Wen Wang, Jia Sun, Shuang Sun, Zhenzhou Huang et autres
Ciliogenesis requires an orchestrated interaction between the Golgi apparatus and centrioles via vesicle trafficking, yet this process is still poorly understood. Phosphatidylinositol 4-kinase β (PI4KB) is a conserved kinase that localizes to the Golgi for generating phosphatidylinositol 4-phosphate, an important lipid component …
cn
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Accès ouvert
2025
article
OpenAlex
Shuang Sun, Zhaoying Wang, Zhaoyang Xu, Zhengfeng Wang et autres
Despite the importance of keratinocytes in epidermal structure and function, the molecular mechanisms regulating the division of these cells remain poorly understood. Herein, we demonstrate an essential role for cilia and flagella associated protein 100 (CFAP100) in keratinocyte division. Cfap100-knockout mice display …
cn
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Accès ouvert
2024
article
OpenAlex
Shuang Sun, Yang Yang, Jun Zhou, Peiwei Liu
Cell division is a highly regulated process essential for the accurate segregation of chromosomes. Central to this process is the assembly of a bipolar mitotic spindle, a highly dynamic microtubule (MT)-based structure responsible for chromosome movement. The nucleation and dynamics of MTs …
cn
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2023
article
OpenAlex
Shuang Sun, Zhaoyang Xu, Hai‐Jie Hu, Manxi Zheng et autres
Bacillus cereusis a Gram-positive bacterium that mainly causes self-limiting emetic or diarrheal illness but can also cause skin infections and bacteremia. Symptoms ofB. cereusingestion depend on the production of various toxins that target the gastric and intestinal epithelia. From a screen of …
cn
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