Lu He

Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism

Weijian Hang, Rui Yin, Lu He, Xuan Cao et autres

BACKGROUND: Coptidis Rhizoma, the rhizome of Coptis chinensis Franch., has long been employed in the treatment of diabetes. Its active component, berberine, has been utilized in clinical practice; however, the underlying mechanisms of its protective effects remain to be fully elucidated. METHODS: …

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Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-Dependent mitophagy

Lin Zhu, Mei Huang, Lu He, Zhihui Rong

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Myeloid deficiency of Z‐DNA binding protein 1 restricts septic cardiomyopathy via promoting macrophage polarisation towards the M2‐subtype

Yifan Shi, Lu He, Jie Ni, Yuyuan Zhou et autres

BACKGROUND: Septic cardiomyopathy is a frequent complication in patients with sepsis and is associated with a high mortality rate. Given its clinical significance, understanding the precise underlying mechanism is of great value. METHODS AND RESULTS: Our results unveiled that Z-DNA binding protein …

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Ruxolitinib Ameliorates Neuronal Pyroptosis in the Acute Phase of Intracerebral Hemorrhage through Inhibiting the Activation of Caspase-8

Guang Chen, Mingming Li, Jiaqi Ma, Lu He et autres

Intracerebral hemorrhage (ICH) is a common type of stroke with higher rates of death and neurological dysfunction than ischemic stroke. Based on previous studies, we found that reducing neuronal pyroptosis in the acute phase of ICH improved the neurological dysfunction of mice …

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A Real-World Pharmacovigilance Study of FDA Adverse Event Reporting System Events for Avelumab

Lu He, Xinyue Zhang, Yanrong Li, Rongrong Li et autres

Background This study utilized data from the FDA Adverse Event Reporting System (FAERS) to investigate adverse drug events (ADEs) associated with avelumab, spanning from the third quarter of 2015 to the first quarter of 2024. Methodology We collected and normalized avelumab ADE …

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Trimethylamine N‐oxide induces pyroptosis in HTR8‐S/Vneo cells through the ten‐eleven translocation 2‐cytochrome b‐reactive oxygen species pathway

Lingli Liang, Yuzhu Rao, Jingjing Wang, Jinli Zhao et autres

AIM: Pyroptosis is a type of programmed cell death characterized by pro-inflammatory activity and is an important factor in pre-eclampsia (PE). Trimethylamine N-oxide (TMAO) is a gut microbial metabolite closely associated with pyroptosis and PE. This study aims to investigate the role …

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An effective method for distinguishing extracellular and intracellular nanoparticles through chemical extractions

Bin Huang, Bowen Li, Lu He, Huan He et autres

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Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K

Lu He, Min Zhu, Rui Yin, Juan Chen et autres

Background: Heart failure (HF) is a serious public health concern. Baicalin is one of the major active ingredients of a traditional Chinese herbal medicine, Huang Qin, which is used to treat patients with chest pain or cardiac discomfort. However, the underlying mechanism(s) …

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Synthesis of europium-based fluorescent films for high-sensitivity detection of iron ions via layered precursor anion exchange

Lu He, Sen Qin, Haoxuan Zeng, Ziyuan Li et autres

NaEu(WO 4 ) 2 /NaEu(MoO 4 ) 2 films were prepared by anion exchange of LEuH films, which were used as Fe 3+ fluorescence sensors based on energy competitive absorption.

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A combined model of circulating tumor DNA methylated SHOX2/SCT/HOXA7 and clinical features facilitates the discrimination of malignant from benign pulmonary nodules

Lu He, Biao Zhang, Chu Zhou, Qi Zhao et autres

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Oxygen Glucose Deprivation-Induced Lactylation of H3K9 Contributes to M1 Polarization and Inflammation of Microglia Through TNF Pathway

Lu He, Rui Yin, Weijian Hang, Jinli Han et autres

BACKGROUND: Hypoxia-induced M1 polarization of microglia and resultant inflammation take part in the damage caused by hypoxic-ischemic encephalopathy (HIE). Histone lactylation, a novel epigenetic modification where lactate is added to lysine residues, may play a role in HIE pathogenesis. This study investigates …

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Research on the Vibration Response of High-Rise Buildings under Blasting Load

Zhenghua Gao, Lu He, Zhen Lei

The vibration caused by blasting load may result in damage to high-rise buildings. In view of this consideration, an investigation of the vibration law was conducted in the context of an actual engineering project. The objective of this study was to analyze …

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