Ziyuan Li

Structure of full-length APOBEC3B bound to EBV BORF2 reveals coordinated neutralization of a cancer-associated mutator

Xiaojiang S. Chen, William Fried, Ziyuan Li, Connor Qiu et autres

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Structure of full-length APOBEC3B bound to EBV BORF2 reveals coordinated neutralization of a cancer-associated mutator

William Fried, Ziyuan Li, Connor Qiu, Lindsey Whalen et autres

Abstract The double-domain APOBEC3B (A3B) contains an N-terminal non-catalytic and C-terminal active cytidine deaminase domains (NTD and CTD). A3B restricts viral infection yet is also a major endogenous mutator in human cancer, driving tumor evolution and drug resistance. A previous study showed …

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Study protocol for a randomized controlled trial of fecal microbiota transplantation via different routes in children with moderate-to-severe autism spectrum disorder

Yigui Zou, Liang Liu, Hu Chen, Zimu Luo et autres

Background: Fecal microbiota transplantation (FMT) shows promise for autism spectrum disorder (ASD) by modulating the gut-brain axis, but the optimal delivery route remains unknown. Our previous single-arm study suggested efficacy of nasojejunal FMT in children with moderate-to-severe ASD, yet could not exclude …

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Phyllanthus emblica L. Polyphenols Mitigate High-Fat Diet-Induced Cognitive Impairment via Modulating Gut Microbiota and Calcium/cAMP Signaling Pathways

Xinyi Deng, Ziyuan Li, Jiamin Tian, fang chen et autres

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Extracellular matrix-mimetic enhanced porous bioscaffolds for accelerating bone defect repair

Baoping Zhang, Ziyuan Li, Zhidong Zhang, Ying Gao et autres

The repair of critical-sized bone defects remains a great challenge in orthopaedics, as present bioscaffolds exhibit insufficient capability in replicating the osteogenic microenvironment (OME). Thus, we developed an extracellular matrix (ECM)-mimetic functionalized bioscaffold (MCS/PCL@PDA@OGP) to address this challenge. The matrix simulates the …

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Exploring the effect of negative mood on working memory subprocesses: An event-related potential study

Qiaoling Hua, Ziyuan Li, Qiang Liu

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Fabrication of metal-organic framework ZIF-67 and Aspergillus niger mycelial pellet biocomposite (ZIF-67@ANMP) and its Congo red adsorption performance

Xinyi Chen, Yuji Ruan, Honglian Chen, Ziyuan Li et autres

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Integrated transcriptomics and metabolomics studies reveal the therapeutic effects of Astragalus polysaccharides on cancer cachexia muscle atrophy

Yong Wang, Xue Liu, Xin Xin, Shuai Liu et autres

Cancer cachexia (CC) is a condition causing significant muscle loss in advanced cancer patients, severely impacting their quality of life and life expectancy. The autophagy-lysosome system is a key pathway in muscle depletion in CC, but targeted therapies are lacking. This study …

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Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis

Yue Hu, Hongduo Lu, Hanjun Fang, Benlu Chen et autres

BACKGROUND: Compelling evidence has implicated osteoblast ferroptosis as a critical contributor to the pathogenesis of glucocorticoid-induced osteoporosis (GIOP). However, the underlying regulatory mechanisms remain poorly understood. METHODS: In the glucocorticoids (GCs)-induced GIOP rat model, both osteoblast dysfunction and ferroptosis markers were assessed. …

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Expression profiles analysis and roles in immunity of transient receptor potential (TRP) channel genes in Spodoptera frugiperda

Hongai Su, Qianxuan Dai, Feiyue Teng, Ziyuan Li et autres

BACKGROUND: Transient receptor potential (TRP) ion channels play crucial roles in mediating responses to environmental stimuli, as well as regulating homeostasis and developmental processes in insects. Several members of the TRP superfamily are potential molecular targets for insecticides or repellents, indicating their …

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Anti-aging effects and mechanisms of Phyllanthus emblica Linn. polyphenols extract targeting Sirt6

Na Wu, Ziyuan Li, Fang Chen, Zeyuan Deng et autres

Abstract The anti-aging effects and possible molecular mechanisms of Phyllanthus emblica Linn. (PE) were investigated in this study. Results revealed that PE extracts increased antioxidant enzyme activities, total antioxidant capacity (T-AOC) levels, and decreased malondialdehyde (MDA) content in the serum and tissues …

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Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection

Zhihao Chen, Qiyuan Jin, Zonggang Xie, Qi Chen et autres

With the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging. Bone infections are mainly caused …

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