Shi-Yu Zhou

Resting-State EEG Characteristics of Tardive Dyskinesia: Spectral and Network Connectivity Insights

L G Yan, Bingyan Xie, Yi Sun, Zheng Miao et autres

Background and Hypothesis: Tardive dyskinesia (TD) is an often irreversible movement disorder, mostly resulting from exposure to dopamine receptor antagonists. The electrophysiological characteristics of TD remain poorly understood. Resting-state electroencephalography (EEG) may help characterize frequency-specific cortical oscillatory and network alterations related to …

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Urate-lowering therapy and kidney outcomes in patients with chronic kidney disease and hyperuricemia

Sheng Nie, Shi-Yu Zhou, Ruixuan Chen, Lantian Li et autres

Hyperuricemia is considered a modifiable risk factor for the development and progression of chronic kidney disease (CKD). There remains controversy over the effects of urate-lowering therapy (ULT) on kidney outcomes in patients with CKD and hyperuricemia. We conducted a cohort study using …

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Analysis of the Construction Path of Contemporary Female Discourse Right in Media Expression

Shi-Yu Zhou

The pluralism of contemporary media environment provides a new opportunity for the generation and dissemination of women's discourse power. The expression of women in mainstream media and self-media shows a transformation from "narrated" to "self-narrated". However, the imbalance of media structure and …

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Microbial biomarkers and sex-associated gut microbiota characteristics of thyroid cancer

Juxiang Gou, Ziyi Hu, Ming Cai, Shirong Zhang et autres

Microbial biomarkers have emerged as promising tools for early cancer detection and disease monitoring. This study aimed to investigate microbial biomarkers and sex-associated differences in gut microbiota associated with thyroid cancer (TC). A total of 268 participants were recruited: 60 females with …

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Metformin-associated gut microbiota remodeling correlates with reinvigorated splenic immunity in aged mice: microbiome-immune crosstalk via the gut-spleen axis

Shu‐Qin Ding, Shi-Yu Zhou, Herrero-Herrero Ji, Jiang-Yan Li et autres

Background and aim Immunosenescence involves age-related immune decline and chronic inflammation, with the spleen serving as a critical hub for immune dysregulation. While gut microbiota influences systemic immunity, its specific role and the potential existence of a gut-spleen axis in mediating splenic …

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Glymphatic System Impairment in Different Stages of Parkinson's Disease: Evidence from DTI-ALPS Imaging

Shi-Yu Zhou, Zhiming Zhen, Zhentao Zuo, Wei Chen

Motivation: Understanding the role of brain glymphatic dysfunction in Parkinson's disease (PD) is crucial for exploring potential therapeutic targets. Goal(s): To evaluate the abnormality of ALPS-index and its association with clinical parameters in PD patients. Approach: 71 PD patients and 102 healthy …

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies

Chao Xie, Ruixuan Chen, Shi-Yu Zhou, Yaduan Lin et autres

BACKGROUND: ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin receptor blockers) are equally recommended as first-line treatment for cardiovascular and renal protection in clinical practice. Evidence on the comparative effectiveness of both drugs on long-term death is inconclusive. METHODS: This multidatabase cohort study …

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How Does Mindfulness Awareness Influence Cognitive Reappraisal in Individuals with Mild Cognitive Impairment? Cognitive Flexibility as a Mediator and Age as a Moderator

Zhuoling Li, Ke Huang, Xiaotong Ding, Tingxuan Wang et autres

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Occurrence and environmental fate/behaviors of tire wear particles and their human and ecological health: an emerging global issue

Xin Li, Shi-Yu Zhou, Tao Zhang, Lei Bai et autres

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Discontinuation of Renin-Angiotensin System Inhibitors during Acute Kidney Injury Episode and All-Cause Mortality

Sheng Nie, Yanqin Li, Yuewen Sun, Shan Chen et autres

Key Points It is uncertain whether the discontinuation of renin-angiotensin system (RAS) improves prognosis among patients during an episode of hospital-acquired AKI. Discontinuation of RAS inhibitors within 2 days after AKI was associated with lower risk of all-cause mortality as compared with …

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Prophylactic antiviral therapy and all-cause mortality in cancer patients with hepatitis B e antigen-negative chronic hepatitis B virus infection receiving immunosuppressive therapy

Sheng Nie, Lisha Cao, Licong Su, Shi-Yu Zhou et autres

BACKGROUND: The survival benefits of prophylactic antiviral therapy for cancer patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B virus (HBV) infection who require immunosuppressive therapy (IST) remain unclear. The present study aims to evaluate the association of prophylactic antiviral therapy …

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Characteristics of patients with undiagnosed stage 3 chronic kidney disease: results from an observational study (REVEAL-CKD) in China

Sheng Nie, Shi-Yu Zhou, Claudia Cabrera, Shan Chen et autres

Background Early diagnosis of chronic kidney disease (CKD) is crucial for timely intervention to delay disease progression and improve patient outcomes.However, data for clinical characteristics of Chinese patients with undiagnosed, early-stage CKD are lacking.Methods REVEAL-CKD is a multinational, observational study using real-world …

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