Microbial biomarkers and sex-associated gut microbiota characteristics of thyroid cancer
Rattachement africain : cn, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Microbial biomarkers have emerged as promising tools for early cancer detection and disease monitoring. This study aimed to investigate microbial biomarkers and sex-associated differences in gut microbiota associated with thyroid cancer (TC). A total of 268 participants were recruited: 60 females with TC, 26 males with TC, and 182 healthy controls. The patient and healthy groups were comparable in terms of age and sex ratio. We first compared the gut microbiota between the patients and healthy participants, followed by sex-specific analyses: female patients vs. female controls, and male patients vs. male controls. Predictive models were used to explore the role of gut microbiota in predicting TC. Correlations between gut microbiota and T stage (i.e., T1 to Tx) were also investigated. The alpha and beta diversities differed between the patients and healthy participants. Sex-specific analysis demonstrated that Blautia and Alistipes were the dominant bacteria shared by both female and male patients. A 25.0% overlap in dominant bacteria was found between the male and female patients. The unique dominant bacteria in female patients constituted 43.8% (7/16) and mainly included Schaalia, Moraxella and Alicyclobacillus. In male patients, the unique dominant bacteria constituted 55.6% (10/18) and included Holdemanella, Clostridium_sensu_stricto, and Senegalimassilia. Regardless of sex, Catenibacterium was the distinguishing feature between patients and healthy participants (area under the curve [AUC] = 0.911). When combined with Aquabacterium and Dialister, the predictive accuracy increased (AUC = 0.992). Male and female patients exhibited both shared and distinct sex-specific microbiota compositions, potentially influenced by hormonal regulation, immune responses, and metabolic differences. These variations may contribute to differences in TC susceptibility and progression. The findings underscore the need for further research to confirm the functional significance of the identified microbiota and explore their potential clinical applications.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Microbial biomarkers and sex-associated gut microbiota characteristics of thyroid cancer
- Date Crossref
- 03/11/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sichuan University Department of Thyroid Surgery pays non établi dans la noticeUniversité ou école supérieure
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West China Hospital of Sichuan University pays non établi dans la noticeÉtablissement de santé
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China National Center for Food Safety Risk Assessment pays non établi dans la noticeOrganisme public
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Sichuan Entry-Exit Inspection and Quarantine Bureau pays non établi dans la noticeOrganisme public
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University of Missouri–Kansas City pays non établi dans la noticeUniversité ou école supérieure
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West China School of Public HealthHealth/West China Fourth Hospital pays non établi dans la noticeUniversité ou école supérieure
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Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province pays non établi dans la noticeStructure de recherche
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School of Nursing and Health Studies pays non établi dans la noticeUniversité ou école supérieure
Department of Thyroid Surgery — Sichuan University, West China Hospital of Sichuan University et China National Center for Food Safety Risk Assessment, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.