Mengmeng Lu

Cunninghamia lanceolata genome illuminates the evolutionary dynamics of gymnosperms

Si-Zu Lin, Yuehua Chen, Chao Wu, Wei-Hong Sun et autres

Cupressaceae , a gymnosperm family, draws attention due to its controversial phylogenetic position. Here, we present a comprehensive genome analysis of Chinese fir (Cunninghamia lanceolata), a Cupressaceae species, to enhance our understanding of gymnosperm evolution. The 11.24 Gb assembled genome, shaped by …

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Enhanced three-dimensional mapping of soil texture components using quantile regression forest and spline techniques in Jiangsu Province, China

Jiangang Xu, Mengmeng Lu

Three-dimensional (3D) modeling of soil texture components serves as an essential tool for the sustainable management of soil and agricultural resources. In this study, a 3D modeling framework was applied in Jiangsu Province, China, integrating the equal-area spline function with the Quantile …

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Multi-omics analyses reveal DjTcf4 critical for proper timing of differentiation in planarian regeneration

Hao Wang, Mengmeng Lu, Lei Huang, Xiaopeng Zou et autres

The blastema is key to forming complete tissues in regenerating Dugesia japonica (D. japonica). However, the dynamic changes in cellular compositions and transcription landscapes in blastema during regeneration are understudied. Here, through genome reannotation, 3D spatial transcriptome construction, single-cell RNA sequencing (scRNA-seq), …

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Artificial Intelligence-Assisted Analysis Of Plaque-Induced Peri-Implant Diseases

Mengmeng Lu, Zhenyu Sun, Yue Hu

Aim or purpose The study aims to develop an AI-deep learning model for effcient intraoral plaque monitoring in dental implant patients and investigate plaque characteristics' correlation with clinical parameters to establish plaque as a predictive biomarker for peri-implant diseases, enabling early prevention …

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Spatial and temporal patterns of precipitation concentration and their associated risks

Xinhao Suo, Yongye Jiang, Guolong Chen, Jingyi Li et autres

Global climate change has profoundly altered precipitation distribution patterns, with the "Wet getting Wetter, Dry getting Drier" (WWDD) pattern widely recognized. However, most previous studies have addressed either the temporal or spatial dimensions of precipitation concentration in isolation, leaving a critical gap …

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Dynamic Redeployment of Nurses Across Hospitals: A Sample Robust Optimization Approach

Wei Liu, T. Li, Mengmeng Lu

Problem definition: We study a workforce redeployment problem in hospital networks, where clinical staff, such as nurses, are temporarily reassigned from overstaffed to understaffed sites to address short-term imbalances. This practice of ``internal travel,'' which gained traction during the COVID-19 pandemic to …

Bright Thermally Evaporated Red Perovskite Light-Emitting Diodes Enabled by In Situ Defect Passivation

Junhao Liu, Xiaorong Shi, Yajing Li, Yuanhao Cui et autres

Thermally evaporated perovskite light-emitting diodes (PeLEDs) hold great promise for high-quality display applications due to their exceptional large-area uniformity and ease of pixelation and integration. Beyond efficiency considerations, display technologies demanded exceptionally high luminance performance from LEDs. While the brightness of blue …

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[Weighted random forest for estimating individualized treatment rules].

Zhong Zhao, Mengmeng Lu, Fang Shao, Dongfang You et autres

With the rapid development of personalized medicine, recommending the optimal treatment regimes among multiple options for individual patients has become a key topic in the study of individualized treatment rules. Existing methods often face challenges such as limited accuracy and robustness when …

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Urinary Bladder Matrix as a Guide Bone Regeneration Barrier Membrane for Inhibiting Cell Invasion and Promoting Bone Formation

Jie Ping Zhong, Zhaoxin Chen, Yanhong Gu, Yiwen Xu et autres

Natural resorbable collagen membranes are widely used in guided bone regeneration (GBR) in oral implantology and prosthodontics. However, the rapid degradation and inadequate mechanical properties raise concerns about potentially compromising the ultimate bone regeneration efficacy. In this study, we developed a novel …

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Adsorption Studies of Sulfamethoxazole and Tetracycline Antibiotics in Seawater by Ceramicized Sludge Biochars

Mengmeng Lu, Xiaohan Ma

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[Statistical design and application of clinical trials with small sample sizes for rare diseases].

Yuan Gao, Zihang Zhong, Mengmeng Lu, Feng Chen

-of-1 design, randomized placebo-phase design, randomized withdrawal design, group sequential design, and adaptive design. It discusses the advantages, disadvantages, and application scenarios of these designs. Additionally, it explores the benefits of Bayes decision-making in clinical trials for rare diseases. The aim is …

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Natural world heritage sites are at risk from climate change globally

Guolong Chen, Bo Fu, Yongye Jiang, Xinhao Suo et autres

Natural world heritage sites face increasing risk under rapid climate change, especially considering the impacts of climate extremes. However, there is not yet enough understanding of the future extreme climate challenges at global natural world heritage sites. Here we identify the exposure …

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