Zhenyu Sun

Systematic Targeting of Protein Complexes with Molecular COUPLrs

Diane Yang, Stefan Harry, Harrison Byron Chong, Neha Khandelwal et autres

Small molecules that modulate protein complexes have transformed cell biology and oncology, yet few chemical starting points exist to probe protein-protein interactions. To expand this space, we developed molecular COUPLrs, elaborated small molecules flanked by two cysteine‑reactive warheads. Using CONNECT, an integrated …

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High-performance co-oscillating electrochemical vector hydrophone based on integrated microelectrodes with microgrooves

Honghao Zhang, Yulan Lu, Lingxiang Hu, Qinghua Liu et autres

This paper reports a high performance co-oscillating electrochemical vector hydrophone based on integrated microelectrodes with microgrooves. Through theoretical and simulation analysis, the influence of key parameters such as the spacing between anode and cathode, depth of microgrooves and the distribution of vias …

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A Compton imaging detection system for neutron resonance capture analysis at Back-n

Jincheng Wang, Jie Ren, Wei Jiang, Suyalatu Zhang et autres

Abstract Neutron resonance capture analysis (NRCA) is a method that utilizes the resonance structures in neutron-induced reactions to determine the elemental composition of materials. It is used for the non-destructive analysis of cultural heritage objects, archaeological artifacts, and reference materials. The back …

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Artificial Intelligence-Assisted Analysis Of Plaque-Induced Peri-Implant Diseases

Mengmeng Lu, Zhenyu Sun, Yue Hu

Aim or purpose The study aims to develop an AI-deep learning model for effcient intraoral plaque monitoring in dental implant patients and investigate plaque characteristics' correlation with clinical parameters to establish plaque as a predictive biomarker for peri-implant diseases, enabling early prevention …

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Complete Mitochondrial Genomes and Phylogenetic Relationships of Myotis siligorensis and Myotis laniger

Xuke Chen, Cheng‐He Sun, Taiyu Chen, Zhenyu Sun et autres

ABSTRACT Bats belong to the order Chiroptera, which represents the second most diverse order among mammals. Bats provide critical ecosystem services through mosquito population control, suppression of agricultural arthropod pests, pollination facilitation, and seed dispersal, while also contributing to human health preservation …

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Electrically-Driven Polarized Nano-Light Sources Based on Suspended Graphene Nanoscrolls

Xu Han, Yunyun Dai, Yongzhi Xie, Lixin Ge et autres

Low-dimensional nanomaterials hold great promise for on-chip light-emitting applications and are expected to profoundly influence the evolution of next-generation photonic chips. Currently, microlasers and light-emitting diodes represent the predominant on-chip integrated light sources. Exploring how to employ low-dimensional materials to realize more …

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Identification and characterization of nanobodies specific for the human ubiquitin–like ISG15 protein

Gan Jin, Prachi Dabhade, Charlotte Wijne, William McKibben et autres

Interferon-induced ubiquitin (Ub)-like modifier ISG15 functions both intracellularly and as a secreted protein with cytokine-like properties. The ISG15 pathway is implicated in various diseases, including cancer and inflammatory disorders, but understanding its precise roles has been challenging due to limited availability of …

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Range of the Key Oversummering Regions of Puccinia striiformis f. sp. tritici in Northwestern China Has Expanded Westward

Liang Huang, Miaomiao Huang, Anna Berlin, Shiqin Cao et autres

(PST), is one of the most important wind-borne diseases in all wheat-growing regions, and its occurrence can lead to devastating yield losses in wheat. In China, the wheat fields in Gansu act as an inoculum reservoir during summer periods and provide PST …

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Analysing the change management process for digital transformation involving citizens using textual analysis techniques

Caihua Liu, Zhenyu Sun, Shufeng Kong

The irreversible trend of digitalisation is reshaping our society, capturing citizens’ attention by delivering high-quality, real-time digital services across various domains. Prior research has primarily concentrated on addressing concerns and challenges related to utilising digital platforms for citizen engagement. This research aims …

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Harnessing technologies to unravel gastric cancer heterogeneity

Yuefan Wang, Ramon U. Jin, Jin Xu, Donghai Lin et autres

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High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis

Jongmin Jacob Woo, Zhenyu Sun, Yingwei Hu, Trung Alvin Hoàng et autres

Pancreatic cancer remains as one of the most challenging malignancies to diagnose and treat due to the late development of symptoms and limited early diagnostic options. Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursors to invasive pancreatic ductal adenocarcinoma (PDAC)and an understanding …

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Abstract 6374: COuPLrs, a new class of cysteine-reactive compounds for modulating protein-protein interaction

Diane Yang, Stefan Harry, Harrison Byron Chong, Edwin M. Zhang et autres

Abstract Molecular glues have revolutionized the targeting of proteins by disrupting protein complexes, showing immense therapeutic potential. However, the discovery of suitable targets for these agents remains largely serendipitous. Unlike traditional monovalent molecular glues, we have developed a novel class of dual-warhead …

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