Yanlin Bi

Assessing Microcirculation Impairment in Ischemic Stroke Mice Using Arteriovenous Co-fluctuation Analysis

Bochao Niu, Yanlin Bi, Benjamin Klugah‐Brown, Yang Yuan et autres

Abstract Accurate assessment of cerebral hemodynamics impairment traditionally relies on arterial metrics, yet often overlooks venous drainage and arteriovenous dynamics, thereby limiting the evaluation of ischemia-induced microvascular dysfunction. To address this limitation, we implemented a signal-averaging framework, combined with co-fluctuation analysis, to …

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Remimazolam compared to dexmedetomidine on the incidence of hypotension in middle aged and elderly patients undergoing general anesthesia: a systematic review and meta-analysis

Mingzhen Wang, Xin Zou, Hong Wang, Xu Lin et autres

BACKGROUND: The objective of this study is to compare the effects of remimazolam and dexmedetomidine on the incidence of hypotension in middle-aged and elderly patients undergoing general anesthesia, and to evaluate the safety profiles of both medications. METHODS: We systematically searched PubMed, …

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Relationship between the preoperative AST/ALT ratio and postoperative delirium and 3-year mortality in patients undergoing total knee or hip arthroplasty: a prospective cohort study

Jian Kong, Shanling Xu, Yuanlong Wang, Shuhui Hua et autres

OBJECTIVE: To investigate the association between the preoperative serum aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio and postoperative delirium (POD) and 3-year mortality in POD patients. METHODS: A total of 538 clinical participants were enrolled from the Perioperative Neurocognitive Disorder and Biomarkers …

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Differential hippocampal protein expression between normal mice and mice with the perioperative neurocognitive disorder: a proteomic analysis

Chuan Li, Jingzhu Li, Tao He, Jinghua Shan et autres

OBJECTIVES: To compare differential expression protein in hippocampal tissues from mice of perioperative neurocognitive disorder (PND) and normal control mice and to explore the possible mechanism of PND. METHODS: Mice were randomly divided into a PND group (n = 9) and a …

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Differential Hippocampal Protein Expression Betweennormal Mice and Mice With the Perioperative Neurocognitive Disorder: a Proteomic Analysis

Chuan Li, Jingzhu Li, He Tao, Jinghua Shan et autres

Abstract ObjectivesTo compare differential expression protein in hippocampal tissues from mice of perioperative neurocognitive disorder (PND) and normal control mice and to explore the possible mechanism of PND. MethodsMice were randomly divided into a PND group(n=9) and a control group(n=9).The mice in …

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Insulin-like growth factor-1 improves postoperative cognitive dysfunction following splenectomy in aged rats

Bin Wang, Xu Lin, Jiahui Zhou, Chunhui Xie et autres

Postoperative cognitive dysfunction (POCD) is a serious complication following anesthesia and operations in aged patients undergoing surgical intervention. It is characterized by temporary or permanent cognitive decline, memory impairment and deterioration in language comprehension and social adaption ability. Therefore, the development of …

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Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimer's disease

Wei Xu, Bing‐Jie Su, Xue‐Ning Shen, Yanlin Bi et autres

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Changes in expression of hippocampal long non-coding RNA and bioinformatics analysis in mice with perioperative neurocognitive disorders

Xiaoxiao Li, Bin Wang, Rui Dong, Jingfu Yu et autres

Objective To evaluate the changes in the expression of hippocampal long non-coding RNA and bioinformatics analysis in mice with perioperative neurocognitive disorders (PND). Methods Thirty clean-grade male C57BL/6 mice, aged 12-14 weeks, weighing 25-30 g, were divided into 2 groups (n=15 each) …

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Effect of acupuncture on cholinergic anti-inflammatory pathway in hippocampus of aged rats during global cerebral ischemia-reperfusion

Xu Lin, Dingwei Liu, Huailong Chen, Fuguo Ma et autres

Objective To investigate the effect of acupuncture on cholinergic anti-inflammatory pathway in the hippocampus of aged rats during global cerebral ischemia-reperfusion (I/R). Methods Ninety-six clean-grade healthy male Sprague-Dawley rats, aged 17-22 months, weighing 440-580 g, were divided into 3 groups (n=32 each) …

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Blood-brain Barrier Disruption Leads to Postoperative Cognitive Dysfunction

Bin Wang, Siyuan Li, Xi‐Peng Cao, Xinghui Dou et autres

BACKGROUND: Postoperative Cognitive Dysfunction (POCD) has received considerable attention as one of the main postoperative complications. The underlying mechanism of POCD in elderly subjects has not been fully elucidated to date. The Central Nervous System (CNS) is isolated from the bloodstream by …

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Effect of dexmedetomidine on mTOR/tau protein signaling pathway in hippocampus of aged rats after splenectomy

Bin Wang, Zeng Yin, Huailong Chen, Lixin Sun et autres

Objective To evaluate the effect of dexmedetomidine on the mammalian target of rapamycin(mTOR)/tau protein signaling pathway in the hippocampus of aged rats after splenectomy. Methods One hundred and fifty pathogen-free healthy male Sprague-Dawley rats, aged 18 months, weighing 400-540 g, were divided …

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Effect of PUN282987 on global cerebral ischemia-reperfusion injury in aged rats

Xu Lin, Fuguo Ma, Huailong Chen, Lixin Sun et autres

Objective To evaluate the effect of PUN282987 on global cerebral ischemia-reperfusion (I/R) injury in aged rats. Methods One hundred and twenty pathogen-free healthy male Sprague-Dawley rats, aged 18-22 months, weighing 450-600 g, were divided into 3 groups (n=40 each) using a random …

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