Accès ouvert
2025
article
OpenAlex
Yongli Zhao, Yizhe Hao, Yi‐Jun Ge, Yi Zhang et autres
BACKGROUND: Evidence indicates that cognitive function is influenced by potential environmental factors. We aimed to determine the variables influencing cognitive function. METHODS: Our study included 164,463 non-demented adults (89,644 [54.51%] female; mean [SD] age, 56.69 [8.14] years) from the UK Biobank who …
cn, gb
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Accès ouvert
2023
article
OpenAlex
Yaoyao Wang, Lina Wang, Xiaoying Chen, Shiguo Liu et autres
BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a rare autosomal dominant disease that is mainly caused by PHOX2B mutations. The purpose of this study is to analyze and summarize the clinical and genetic characteristics of CCHS patients in the Chinese population from …
cn
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2023
article
OpenAlex
Xi‐Peng Cao, Wei Xu, Zuo-Teng Wang, Lan Tan et autres
BACKGROUND: For decades, evidence from observational studies and randomized controlled trials has converged to suggest associations of dietary components, foods, and dietary patterns with dementia. With population aging and a projected exponential expansion of people living with dementia, formulating nutritional strategies for …
cn
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Accès ouvert
2022
article
OpenAlex
Lian Tang, Zhibo Wang, Lingzhi Ma, Xi‐Peng Cao et autres
Abstract Background Clusterin is a multifunctional protein, which is associated with the pathogenesis and the development of Alzheimer’s disease (AD). Compared with normal controls, inconsistent results have yielded in previous studies for concentration of cerebrospinal fluid (CSF) clusterin in AD patients. We …
cn
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Accès ouvert
2022
article
OpenAlex
Yan Fu, Zuo-Teng Wang, Liangyu Huang, Chen‐Chen Tan et autres
Background Perturbation of lipid metabolism is associated with Alzheimer’s disease (AD). Heart fatty acid-binding protein (HFABP) is an adipokine playing an important role in lipid metabolism regulation. Materials and methods Two datasets separately enrolled 303 and 197 participants. First, we examine the …
cn
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Accès ouvert
2022
article
OpenAlex
Wenmin Hu, Yongmei Shi, Tongqin Han, Caiyun Liu et autres
Hepatocellular carcinoma is one of the most malignant tumors, and the therapeutic effects of traditional treatments are poor. It is urgent to explore and identify new biomarkers and therapeutic targets to develop novel treatments which are individualized and effective. Three hallmarks, including …
cn
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Accès ouvert
2022
review
OpenAlex
Shuai Xiang, Jin-Long Ji, Sha Li, Xi‐Peng Cao et autres
Background Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common neurodegenerative diseases, and mild cognitive impairment (MCI) is considered a prodromal stage of clinical AD. Animal studies have shown that probiotics can improve cognitive function and mitigate inflammatory …
cn
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Accès ouvert
2021
article
OpenAlex
Xinyu Yang, Xiao‐He Hou, Yanlin Bi, Hao Hu et autres
BACKGROUND: Anaemia has been reported to be associated with cognitive decline and Alzheimer's disease (AD), but the associations between anaemia and cerebrospinal fluid (CSF) AD biomarkers are still unknown. This study aimed to investigate the associations between anaemia and CSF AD biomarkers. …
cn
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2021
article
OpenAlex
Lin Li, Wei Xu, Chen‐Chen Tan, Xi‐Peng Cao et autres
BACKGROUND AND PURPOSE: The present study aimed to explore whether and how omega-3 (ω-3) supplementation could interact with genetic factors to modulate cognitive functions, amyloid pathologies, and Alzheimer's disease (AD) risk. METHODS: A total of 1,670 non-demented participants (mean age 73 years, …
cn
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2021
article
OpenAlex
Zuo-Teng Wang, Kunyan Li, Chen‐Chen Tan, Wei Xu et autres
Background: The relationship between alcohol consumption and Alzheimer’s disease (AD) pathology is unclear. Amyloid-β (Aβ) and tau biomarkers in cerebrospinal fluid (CSF) have been proven valuable in establishing prognosis in pre-clinical AD. Objective: We sought to examine the associations between alcohol consumption …
cn
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2021
article
OpenAlex
Wei Xu, Chen‐Chen Tan, Juanjuan Zou, Xi‐Peng Cao et autres
BACKGROUND: It is suggested that not all individuals with elevated Aβ will develop dementia or cognitive impairment. Environment or lifestyle might modulate the association of amyloid pathology with cognition. Insomnia is a risk factor of cognitive disorders including Alzheimer's disease. OBJECTIVE: To …
cn
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2021
article
OpenAlex
Yayu Wang, Yi‐Jun Ge, Chen‐Chen Tan, Xi‐Peng Cao et autres
BACKGROUND: The apolipoprotein E epsilon 4 (APOE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). Its carriage percentage in non-demented population varies across geographic regions and ethnic groups. OBJECTIVE: To estimate the proportion of APOE4 (2/4, 3/4, or 4/4) …
cn
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