Emily Huang

RIP3 and MLKL regulate ER stress in alcohol-associated liver disease and pharmacological ER stress models: Insights beyond necroptosis

Rakesh K. Arya, Emily Huang, Megan R. McMullen, Kyle L. Poulsen et autres

Background & Aims Endoplasmic reticulum (ER) stress is an important contributor to liver disease progression, including alcohol-associated liver disease. Although receptor-interacting protein kinase-3 (RIP3) and mixed lineage kinase domain-like pseudokinase (MLKL) are known for their roles in necroptosis, emerging evidence highlights their …

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Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet‐Dependent Thrombin Formation and Release of Profibrotic TGF ‐β

Emily Huang, Xianfang Wu, Megan R. McMullen, Laura E. Nagy et autres

Dysregulated coagulation and platelet activation contribute to liver dysfunction and fibrosis, but mechanisms initiating these events are undefined. The hepatic stellate cell (HSC) agonist Concanavalin A (ConA) rapidly induces hepatitis, which progresses to hepatic fibrosis after serial exposure for 8 weeks. Extravascular …

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Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol Abuse

Evi Paouri, Sarah Stanko, Nadia Gasmi, Gabriele Glusauskas et autres

Abstract Alcohol abuse is the primary risk factor for alcohol use disorder (AUD), a leading cause of preventable morbidity and mortality, characterized by systemic inflammation, multi-organ damage, and neurological impairments. While direct effects of alcohol on brain function are well-established, the role …

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Comprehensive assessment of genomic heterogeneity, coalterations, and outcomes of patients with colorectal cancer: An AACR GENIE project analysis

Hunter Stecko, Diamantis I. Tsilimigras, Sidharth Iyer, Jad Daw et autres

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Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses

Jared Travers, Emily Huang, Megan R. McMullen, Jianguo Wu et autres

ABSTRACT Nucleic acid-induced activation of the anti-viral transcription factor interferon regulatory factor 3 (IRF3) promotes transforming growth factor-beta (TGFβ)-induced fibrotic responses of hepatic stellate cells in vitro . Herein, we identified molecular mechanisms underlying TGFβ-induced IRF3 activation. Gene silencing of IRF3 with …

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FRI-387 35 kilodalton specific-sized hyaluronan ameliorates high fat diet-induced liver injury in a murine model of moderate

Semanti Ray, Emily Huang, Megan R. McMullen, Samreen Jatana et autres

Characterizing surveillance-associated anxiety following curative-intent surgery for gastrointestinal cancer: a mixed methods approach

Natalie Bath, Patrick L. Quinn, Joanne Kim, Mary Dillhoff et autres

PURPOSE: Imaging is often an essential component of cancer surveillance following curative-intent surgery but can be distressing for some patients. While this phenomenon has been studied among patients undergoing active cancer treatment and screening, the frequency and severity of "scanxiety" among patients …

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Association of non–gain-of-function alterations in exportin-1 with improved overall survival in colorectal cancer

Hunter Stecko, Diamantis I. Tsilimigras, Sidharth Iyer, Jad Daw et autres

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35k Da specific-sized hyaluronan ameliorates high-fat diet-induced liver injury in murine model of moderate obesity

Semanti Ray, Emily Huang, Megan R. McMullen, Samreen Jatana et autres

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The pyruvate dehydrogenase kinase inhibitor dichloroacetate mitigates alcohol-induced hepatic inflammation and metabolic disturbances in mice

Jianguo Wu, Emily Huang, Megan R. McMullen, Vaibhav Singh et autres

BACKGROUND: Dichloroacetate (DCA), a pan-pyruvate dehydrogenase kinase inhibitor, ameliorates multiple pathological conditions and tissue injury and shows strong potential for clinical applications. Here, we investigated the preventive effects of DCA in a murine model of alcohol-associated liver disease. METHODS: C57BL/6J mice were …

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ASO Visual Abstract: Clinical Outcomes, Costs, and Value of Undergoing Surgery Among Older Patients with Colon Cancer at U.S. News & World Report Ranked Versus Unranked Hospitals

Abdullah Altaf, Selamawit Woldesenbet, Muhammad Musaab Munir, Muhammad Muntazir Mehdi Khan et autres

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Clinical Outcomes, Costs, and Value of Surgery Among Older Patients with Colon Cancer at US News and World Report Ranked Versus Unranked Hospitals

Abdullah Altaf, Selamawit Woldesenbet, Muhammad Musaab Munir, Muhammad Muntazir Mehdi Khan et autres

BACKGROUND: US News and World Report (USNWR) hospital rankings influence patient choice of hospital, but their association with surgical outcomes remains ill-defined. We sought to characterize clinical outcomes and costs of surgery for colon cancer among USNWR top ranked and unranked hospitals. …

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