Natalie Bath

A National Survey of Contracts, Compensation, and Workplace Culture Among Junior Surgical Oncologists

Christopher P. Childers, Hideo Takahashi, Kelly L. Koch, Natalie Bath et autres

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OMIP‐119 : A 36‐Color Full‐Spectrum Flow Cytometry Panel for Deep Immunophenotyping of Peripheral Blood and Ex Vivo Expanded Human T Cells

R. J. C. Harris, Benjamin Arkle, Elizabeth Evans, Rebecca Teevan et autres

ABSTRACT The increasing uptake of adoptive CAR‐T and TCR‐T cell therapies into clinical practice has intensified the need for robust and detailed immunophenotyping of ex vivo expanded T cells. We have developed and optimized an extended 36‐color full‐spectrum flow cytometry panel suitable …

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Society of surgical oncology medical student & trainee primer for non-HPB GI oncology

Hideo Takahashi, Micah J Brainerd, Natalie Bath, Brian K. Sparkman et autres

The goal of this primer is to educate the future generation of surgeons and prepare trainees for their clinical rotations in the operating room and with patient care. This primer will introduce medical students and trainees to the diagnosis and management of …

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Society of surgical oncology medical student & trainee primer for skin, soft tissue, and endocrine surgical oncology

Danielle S. Graham, Andrew Francis, Micah J Brainerd, Ian C. Garbarine et autres

The goal of this primer is to educate the future generation of surgeons and prepare trainees for their clinical rotations in the operating room and in the clinic. This primer will introduce medical students and trainees to the diagnosis and management of …

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322 Single-cell RNA sequencing of afamitresgene autoleucel indicates mechanisms of persistence and anti-tumor activity

Sterenn Davis, Alex J. Tipping, Ian J. Donaldson, Alasdair Gunn et autres

Background Afamitresgene autoleucel (afami-cel) is an engineered T-cell receptor (TCR) T-cell therapy targeting tumors expressing melanoma-associated antigen (MAGE) A4 and is the first such therapy with advanced FDA approval for a solid tumor. In the Phase 2 SPEARHEAD-1 trial in patients with …

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Characterizing surveillance-associated anxiety following curative-intent surgery for gastrointestinal cancer: a mixed methods approach

Natalie Bath, Patrick L. Quinn, Joanne Kim, Mary Dillhoff et autres

PURPOSE: Imaging is often an essential component of cancer surveillance following curative-intent surgery but can be distressing for some patients. While this phenomenon has been studied among patients undergoing active cancer treatment and screening, the frequency and severity of "scanxiety" among patients …

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Preclinical Proof of Concept for Decentralized Manufacturing of a MAGE-A4/CD8α-Expressing Autologous T-Cell Therapy for Solid Tumors

Melissa Herman, Stefania Gobessi, Laurens G.L. Sand, Karolin Wagner et autres

Introduction: Uzatresgene autoleucel (uza-cel) is a next-generation T-cell therapy targeting melanoma-associated antigen (MAGE) A4. Uza-cel uses the same engineered T-cell receptor (TCR) as afamitresgene autoleucel (afami-cel), which has shown efficacy in synovial sarcoma (NCT04044768; D'Angelo SP. Lancet. 2024;403:1460) with an additional CD8α …

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368 Translational analyses reveal mechanisms of afami-cel’s anti-tumor activity in synovial sarcoma

Christopher D. Dupont, Natalie Bath, Robyn Broad, Megan Butler et autres

Background Afamitresgene autoleucel (afami-cel) is an adoptive cell therapy wherein patients are infused with autologous T cells engineered to target tumor cells expressing the cancer/testis antigen melanoma-associated antigen A4 (MAGE-A4). Afami-cel has previously demonstrated clinical benefit in patients with synovial sarcoma.1Herein, we …

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Surgical Second Opinion for Pancreatic Cancer Patients

Patrick L. Quinn, Melica Nikahd, Shah Saiyed, Addie Heifetz et autres

BACKGROUND: Due to the complexity of pancreatic surgery, patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) may seek out the opinion of more than 1 surgeon. Little is known regarding how second surgical opinions impact the likelihood of pancreatectomy and perioperative outcomes. Our …

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Patient Perceptions of Care Coordination during Neoadjuvant Therapy for Gastrointestinal Cancers: A Mixed Methods Analysis

Natalie Bath, Marilly Palettas, Lena Stevens, Angela Sarna et autres

PURPOSE: Effective cancer care coordination (CCC) is an integral component of health care delivery and critical to achieving optimal oncologic outcomes. Neoadjuvant therapy (NT), the delivery of multimodality therapy prior to surgery, is inherently complex and multidisciplinary, but CCC during NT is …

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A narrative review of the history and recent advances in minimally invasive pancreatic resection

Alexander H. Shannon, Natalie Bath, Aslam Ejaz

Pancreatic resections are complex operations that carry the potential for long-term and life-threatening complications. Over the past several decades, improved surgical techniques and perioperative care have decreased the morbidity and mortality associated with these operations. As laparoscopic and robotic-assisted surgery has been …

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1174 PATIENT PERCEPTIONS OF CARE COORDINATION DURING NEOADJUVANT THERAPY FOR GASTROINTESTINAL CANCERS: A MIXED METHODS ANALYSIS

Natalie Bath, Marilly Palettas, Lena Stevens, Angela Sarna et autres