Hongliang Yao

Sulfation and carboxymethylation of Citrus medica ‘Fingered’ polysaccharides: Physicochemical properties and protective effects against LPS-induced intestinal barrier injury in Caco-2 cells

Feng Xiong, Hongliang Yao, Yifan Wu, Wenhao Hu et autres

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A galacturonic acid-rich polysaccharide from Citrus medica ‘fingered’ alleviated the dextran sulfate sodium-induced ulcerative colitis

Feng Xiong, Hongyi Li, Hongliang Yao, Yanghui Ou et autres

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Anti-inflammatory activity and underlying mechanism against sepsis-induced acute lung injury of a low-molecular-weight polysaccharide from the root of Stemona tuberosa Lour

Xiang Qiu, Yan Geng, Xiaoyue Cai, Yanghui Ou et autres

The root of Stemona tuberosa Lour has been used to treat tuberculosis, scabies, and eczema. Polysaccharides are among its main bioactive ingredients. A low-molecular-weight (1819 Da) polysaccharide (SPS2-A) was obtained from the root of S. tuberosa Lour by optimizing three-phase partitioning, purified …

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Study of the Structure and Bioactivity of Polysaccharides from Different Parts of Stemona tuberosa Lour

Xiang Qiu, Yanghui Ou, Shengjia Lu, Yibin Liang et autres

The polysaccharides from Stemona tuberosa Lour, a kind of plant used in Chinese herbal medicine, have various pharmacological activities, such as anti-inflammatory and antioxidant properties. However, the effects of the extraction methods and the activity of polysaccharides from different parts are still …

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Unified and green oxidation of amides and aldehydes for the Hofmann and Curtius rearrangements

Liyan Song, Yufei Meng, Tongchao Zhao, Lifang Liu et autres

The oxone–halide green oxidation system is extended to the oxidation of primary amides and aromatic aldehydes (with sodium azide) to generate N -haloamide and acyl azides, respectively, for subsequent Hofmann and Curtius rearrangements.

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Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury

Liyan Song, Gang Li, W. Guan, Zhijun Zeng et autres

Acute lung injury (ALI) is an inflammation-mediated respiratory disease with a high mortality rate. Medications with anti-inflammatory small molecules have been demonstrated in phase I and II clinical trials to considerably reduce the ALI mortality. In this study, two series of lansiumamide …

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Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities

Gang Li, Jia‐Qiang Wu, Xiaojia Cai, Wen Guan et autres

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Two Green Protocols for Halogenative Semipinacol Rearrangement

Liyan Song, Yiqin Zhou, Hanbin Liang, Hongzuo Li et autres

Semipinacol rearrangement is a special type of Wagner–Meerwein rearrangement that involves carbocation 1,2-rearrangement to provide carbonyl compounds with an α-quaternary carbon center. It has been strategically used for natural product synthesis and construction of highly congested quaternary carbons. Herein, we report a …

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Mechanism study of ultrasonic-assisted screening of fine powder materials

Ya-Zhe Chen, Hongliang Yao

The strong adsorption characteristics of fine power materials give rise to problems such as material conglomeration, blockage of sieve mesh and low process efficiency during screening, thus necessitating studies on processes like ultrasonic-assisted powder materials screening. In this study, based on the …

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Metabolic profiling and pharmacokinetic studies of Baihu-Guizhi decoction in rats by UFLC-Q-TOF–MS/MS and UHPLC-Q-TRAP-MS/MS

Yan He, Zhenkun Zhou, Weijie Li, Yanqiong Zhang et autres

BACKGROUND: Baihu-Guizhi decoction (BHGZD) is a well-documented traditional Chinese Medicine (TCM) prescription that has been extensively applied to treating rheumatoid arthritis. Despite of its beneficial outcomes, the chemical constituents of BHGZD have not been fully portrayed and the in vivo absorption, distribution, …

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Environmentally Benign and User-Friendly In Situ Generation of Nitrile Imines from Hydrazones for 1,3-Dipolar Cycloaddition

Liyan Song, Yunrong Lai, Hongzuo Li, Jipeng Ding et autres

Nitrile imines are highly reactive and versatile dipoles and conventionally generated in situ from unstable hydrazonyl halides under basic conditions. Herein, we report the first green and user-friendly protocol for in situ generation of nitrile imines from Oxone–KBr oxidation of hydrazones and …

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1,5‐Allyl Shift by a Sequential Achmatowicz/Oxonia‐Cope/Retro‐Achmatowicz Rearrangement

Xiayan Zhang, Yi Tong, Gang Li, Hao Zhao et autres

Abstract 1,3‐Allyl and 1,2‐allyl shifts through [3,3]‐ and [2,3]‐sigmatropic rearrangements are well‐established and widely used in organic synthesis. In contrast, 1,5‐allyl shift through related [3,5]‐sigmatropic rearrangement is unknown because [3,5]‐sigmatropic rearrangement is thermally Woodward–Hoffmann forbidden. Herein, we report an unexpected discovery of …

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