Fang Wei

Construction of Multi-Substituted gem -Difluoropyran Derivatives: Tension Ring-Expansion of gem -Difluorocyclopropene with Allyl Alcohols

Jie Liao, Yong‐Jie Hu, Qi-Hua Zhang, Hang-Jiang Lu et autres

Abstract A novel structurally diverse gem-difluorinated 2H- and 4H-pyrans derivatives have been efficiently synthesized by Fe(III)-catalyzed reductive radical cycloexpansion of gem-difluorocyclopropenes with allyl alcohols. Preliminary mechanistic studies suggest that the process via hydrogen atom transfer (HAT) to generate an alkyl radical, which …

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Synthesis of diiron subcluster [Fe2[(μ-SCH2)2NH](CN)2(CO)4]2− for artificial maturation of [FeFe]-hydrogenases

Xin Yu, Fang Wei, Thomas B. Rauchfuss

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Aging properties of polyethylene microplastics in soil and the adsorption behaviors towards coexisting antibiotic

Tianci Sun, Yue Wang, Ming Zhang, Fang Wei et autres

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Recent advances in asymmetric bimetallic catalysis

Fang Wei, Jialin Qi, Xiangqing Jia, Zhenghu Xu

Asymmetric bimetallic catalysis has emerged as a powerful and efficient approach for the development of novel enantioselective transformations. By employing two metal centers with complementary reactivity, bimetallic catalysts enable dual substrate activation, stabilize reactive intermediates, and facilitate unique transformations with high enantioselectivity. …

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Co-infection of Helicobacter pylori with Epstein-Barr virus in gastric organoids enhances cell proliferation and morphogenesis

Caixia Zhu, Shuxin Zhang, Yantao Duan, Yulin Zhang et autres

ABSTRACT Helicobacter pylori ( H. pylori ) is a key cause of chronic inflammation and gastric cancer, and Epstein-Barr virus (EBV) also contributes to gastric tumorigenesis. However, the role of EBV co-infection in H. pylori -related cancers remains unclear because of the …

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Discovery of Highly Potent and Selective EZH2 Covalent Inhibitors via Incorporating Basic Amines

Yi Zhang, Qiongyu Shi, Fang Wei, Li Liu et autres

Targeted covalent inhibition is a promising strategy to address the high dose and acquired drug resistance issues of the first-generation EZH2 noncovalent inhibitors. Recently we have reported a new generation of highly potent EZH2 covalent inhibitors, but further optimization to enhance aqueous …

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Role of IP3R2-Mediated mitochondrial calcium homeostasis in early hypoxic stress injury of retinal pigment epithelial cells

Li Xu, Fang Wei

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Organocatalyzed Enantioselective C–N Bond-Forming S N Ar Reactions for Synthesizing Stereogenic-at-Boron BODIPYs

Fang Wei, Wen‐Hao Chen, Shu-Ying Ding, Meng‐Lan Shen et autres

The precise construction of boron stereogenic centers represents a significant, yet challenging frontier in asymmetric catalysis, garnering growing attention in recent years. However, feasible catalysis has primarily been limited to transition-metal-catalyzed desymmetrization of pro-chiral BODIPY molecules, while enantioselective synthesis via organocatalysis remains …

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Unlocking Chiral Sulfinimidoyl Electrophiles: Asymmetric Synthesis of Sulfinamides Catalyzed by Anionic Stereogenic-at-Cobalt(III) Complexes

Hua‐Jie Jiang, Fang Wei, Xinran Chen, Xin-Ran Yu et autres

Asymmetric catalysis involving a sulfoxide electrophile intermediate presents an efficient methodology for accessing stereogenic-at-sulfur compounds, such as sulfinate esters, sulfinamides, etc., which have garnered increasing attention in modern pharmaceutical sciences. However, as the aza-analog of sulfoxide electrophiles, the asymmetric issues about electrophilic …

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Metal-free iodosulfonylation of alkynes to access ( E )-β-iodovinyl sulfones in water

Guiting Peng, Fang Wei, Jiang Bai, Haixin Ding et autres

)-β-iodovinyl sulfones in water is reported. This reaction gives the desired products in good to excellent yields with high regio- and stereoselectivity by using water as a green solvent at room temperature. This reaction could be readily scaled up, and synthetic application …

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A Dual-Mode Sensing Platform Based on Covalent Organic Framework for Detection of Lipase Activity and its Inhibitors

Sikai Wang, Weiping Liu, Fang Wei, Lei Wang et autres

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Study on Synthesis of Glycine by Electrooxidation of Ethanolamine

Ying Li, Shuozhen Hu, Fang Wei, Xing Xiao et autres