Sha Gong

Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy

Lu Wang, Sha Gong, Jun Wang, Yingying Bao et autres

BACKGROUND: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with dismal outcomes, especially in relapsed/refractory settings. Chimeric antigen receptor natural killer (CAR-NK) cell therapy holds promise but is constrained by the immunosuppressive tumor microenvironment (TME), where adenosine-mediated suppression is a key …

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Multi-omics analysis identifies key pathways and hub genes in the antimony tolerance network of soybean (Glycine max L.)

Liang You, Sha Gong, Guoxiang Jiang, Renyan Duan et autres

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LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity

Junyan Li, Ying-Qing Li, Jia‐Hao Dai, Sha Gong et autres

The efficacy of anticancer treatments, including radiotherapy, depends on the activation of type I IFN signaling. However, its regulatory networks and mechanisms remain to be elucidated. Here, we report that tumor cell-intrinsic type I IFN signaling can be transferred to macrophages via …

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Integrated physiological, transcriptomics, and metabolomics offer novel insights into the mechanisms of antimony resistance in Glycine max L

Liang You, Sha Gong, Guoxiang Jiang, Renyan Duan et autres

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Genome-Wide Identification of the OPT Gene Family and Screening of Sb-Responsive Genes in Brassica juncea

Xianjun Liu, Mingzhe Chen, Yuhui Yuan, Jialin Sheng et autres

Antimony (Sb), a toxic metalloid, inhibits plant growth and threatens human health. Yellow Stripe-Like (YSL) proteins play crucial roles in metal ion transport and cellular homeostasis. While the OPT gene family has been characterized in some species, its genome-wide organization and functional …

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A novel feeder cell based on 4-1BBL and membrane-bound IL-21/IL-15 induce highly expansion and anti-tumor effect of natural killer cells

Sha Gong, Nan Mei, Jun Wang, Junsheng Zhu et autres

BACKGROUND: Natural killer (NK) cell immunotherapy is a promising approach for cancer treatment. However, its extensive clinical application was limited to the large-scale clinical-grade expansion of NK cells. In this study, we expanded NK cells from healthy donor's peripheral blood mononuclear cells …

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Tissue-resident microbiota signature in nasopharyngeal carcinoma

Xi-Rong Tan, Han Qiao, Ying-Qing Li, Wei Jiang et autres

Emerging evidence reveals that microbiota plays a crucial role in multiple cancers. Nasopharyngeal carcinoma (NPC) tissues harbour microbiota, highlighting the need to investigate the clinical implications of tissue-resident microbiota in the development of NPC. Here, we aim to clarify the specific profile …

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Membrane‐Anchoring and Oxygen‐Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy

Qing Chuan Zhao, Ye Ji Han, Wushuang Gong, Zhiyue Cao et autres

Despite its antitumor promise, sonodynamic therapy (SDT)'s efficacy in immune activation requires enhancement, primarily due to the hypoxic tumor microenvironment (TME) and insufficient targeting of sonosensitizers to specific subcellular regions. Herein, we developed macrophage membrane (MM)-intermingled membrane fusogenic liposomes (MFL) to optimize …

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Effect of palatoplasty technique on otologic outcomes in children with cleft palate

Sha Gong, Paul P. Hung, Chioma G. Obinero, Jose Enrique Barrera et autres

BACKGROUND: In patients with cleft palate (CP), the impact of primary palatoplasty technique on otologic outcomes remains a major point of contention. While some studies report improved outcomes after certain techniques of palatal repair, there is a lack of consensus on the …

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Gene Regulation by a Kinetic Riboswitch with Negative Feedback Loop

Sha Gong, Yujie Wang, Chengyi Du

Understanding the folding behaviors and cellular roles is important to fully illuminate functions of riboswitches in vivo . Since riboswitches act without the need for protein factors, RNA structure prediction methods are ideally suited for computationally analyzing their cellular activities. Here, a …

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Integrated Physiological, Transcriptomics, and Metabolomics Offer Novel Insights into the Mechanisms of Antimony Resistance in Glycine Max L

Liang You, Sha Gong, Guoxiang Jiang, Renyan Duan et autres

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Arsenic trioxide versus Realgar-Indigo naturalis formula in non-high-risk acute promyelocytic leukemia: a multicenter, randomized trial

Shu Chen, Weiwei Qin, Xiaohong Lü, Li Liu et autres

Realgar-Indigo naturalis formula (RIF) is an oral form of arsenic that is effective against acute promyelocytic leukemia (APL). This multicenter, randomized, controlled trial compared the efficacy of all-trans retinoic acid (ATRA) plus RIF with ATRA plus arsenic trioxide (ATO) in a simplified …

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