Huanyu Zhang

Bisphenol S exposure before sexual maturity impairs follicular development via Cathepsin L-mediated granulosa cell death

Fei Li, Fuhai Shen, Yuxia Zhou, Yongfei Zheng et autres

Bisphenol S (BPS) poses potential risks to the reproductive system, but its effects during pre-sexual maturity on follicle development and its underlying mechanisms remain unclear. This study aimed to investigate the association between pre-sexual BPS exposure and follicular dysplasia, as well as …

cn (code pays fourni par la source)

Nursing interns’ experiences of bullying from clinical instructors and nurses in China: a qualitative study

Yufeng Liao, Peng Fei Xiao, Min Lin, Huanyu Zhang et autres

BACKGROUND: Clinical placement serves as a vital bridge between theoretical instruction and professional nursing practice, offering nursing interns the opportunity to translate knowledge into real-world patient care. However, experiences of bullying during clinical placements substantially undermine the quality and effectiveness of nursing …

cn, gb, hk (code pays fourni par la source)

Capability wellbeing of parents caring for children with rare diseases: a national cross-sectional study

Jiazhou Yu, Huanyu Zhang, Shanquan Chen, Richard Huan Xu et autres

BACKGROUND: Rare diseases impose significant burden on families, particularly parents, of affected children, involving intensive caregiving, financial hardship, and social isolation. However, there is a scarcity of research exploring the broader dimensions of parental wellbeing, such as enjoyment and achievement. This study …

hk, cn (code pays fourni par la source)

Health-related Quality of Life among Children Living with Rare Diseases in China: a Nationwide Study

Jiazhou Yu, Huanyu Zhang, Shanquan Chen, Richard Huan Xu et autres

A large proportion of rare diseases (RDs) manifest in childhood, posing substantial physical and psychosocial burden on pediatric populations. This study aims to evaluate the health-related quality of life (HRQoL) and associated factors among children living with RDs across key age groups …

hk, cn (code pays fourni par la source)

Structure and function of the nairovirus cap-snatching endonuclease

Wenhua Kuang, Gan Zhang, Fan Wu, Jinyue Li et autres

Abstract Nairoviruses include several human pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) and Kasokero virus (KASV). The cap-snatching endonuclease (EN) domain of the viral polymerase is essential for transcription and represents a promising antiviral target. However, the structural and functional mechanisms …

cn, cz (code pays fourni par la source)

OpenGPT-4o-Image: A Comprehensive Dataset for Advanced Image Generation and Editing

Zhihong Chen, Yang Shi, Chaoyou Fu, Huanyu Zhang et autres

The performance of unified multimodal models for image generation and editing is fundamentally constrained by the quality and comprehensiveness of their training data. While existing datasets have covered basic tasks like style transfer and simple object manipulation, they often lack the systematic …

BaseReward: A Strong Baseline for Multimodal Reward Model

Yifan Zhang, Haihua Yang, Huanyu Zhang, Yang Shi et autres

The rapid advancement of Multimodal Large Language Models (MLLMs) has made aligning them with human preferences a critical challenge. Reward Models (RMs) are a core technology for achieving this goal, but a systematic guide for building state-of-the-art Multimodal Reward Models (MRMs) is …

Gingipains disrupt bone homeostasis via dual regulation of osteogenesis and osteoclastogenesis through exosomal miR-146a-5p/TRAF6 signaling

Jiachen Dong, Yue Liao, Mengjun Sun, Huiwen Chen et autres

Background Gingipains are virulence factors released by Porphyromonas gingivalis that contribute to periodontal destruction by disrupting bone metabolism. This study aimed to evaluate the dual effects of gingipains on bone metabolism by examining their impact on osteogenesis and osteoclastogenesis, hypothesizing that gingipains …

cn (code pays fourni par la source)

Discontinuity of social support among US adults with cognitive impairment before and after the confirmed diagnosis of dementia: a matched ambidirectional cohort study

Huanyu Zhang, Benjamin R. Underwood, Sabina London, Jiazhou Yu et autres

BACKGROUND: Despite increased attention on dementia, much remains unknown about the integration of clinical and non-clinical care, particularly regarding long-term social support, a primary source of non-clinical care. This study uniquely examines the effect of receiving a formal dementia diagnosis on the …

cn, gb, us, hk (code pays fourni par la source)

Memory-Efficient Differentially Private Training with Gradient Random Projection

Alex Mulrooney, Devansh Gupta, James Flemings, Huanyu Zhang et autres

Differential privacy (DP) protects sensitive data during neural network training, but standard methods like DP-Adam suffer from high memory overhead due to per-sample gradient clipping, limiting scalability. We introduce DP-GRAPE (Gradient RAndom ProjEction), a DP training method that significantly reduces memory usage …

Benchmark testing for 2H neutron cross section calculated using Faddeev equation

Huanyu Zhang, Haicheng Wu, Ruirui Xu, Ping Liu et autres

cn (code pays fourni par la source)

Global Dispatching of Distributed Cluster Flow Based on Dijkstra and Multi-Strategy in Power Grid

Huanyu Zhang, Wenbin Cai, Dawu Wang, Zhilong Chen et autres

Affected by the uneven distribution of business traffic in the network, the principle of “many-to-one” data collection limits the process of finding the shortest path, resulting in a low degree of load balance, a trend of reduced throughput and unstable output results …

cn (code pays fourni par la source)