Christina D. Wagner

Multiomics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeutic Discovery

Aleksandr Ianevski, Kristen Nader, Julia Nguyen, Helena Sorger et autres

T-cell leukemias and lymphomas (TCL) form a heterogeneous group of rare and often aggressive malignancies. Because of the rarity and heterogeneity of TCL subtypes, clinical trials are challenging to conduct, making pharmacogenomic studies in cell line panels critical for the discovery of …

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A STAT5B-driven mouse model of hepatosplenic γδ T-cell lymphoma reveals therapeutic efficacy of JAK inhibition

Myint Myat Khine Aung, Susann Schönefeldt, Sophie Pfalz-Kraupp, Tamara Wais et autres

Abstract Hepatosplenic T-cell lymphoma (HSTCL) is a rare and aggressive neoplasm associated with poor responses to standard chemotherapy regimens and low survival rates. No targeted therapies are available for HSTCL, and preclinical models to test new treatment options have not been established. …

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Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma

Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. de Araujo et autres

The transcription factors STAT3, STAT5A, and STAT5B steer hematopoiesis and immunity, but their enhanced expression and activation promote acute myeloid leukemia (AML) or natural killer/T cell lymphoma (NKCL). Current therapeutic strategies focus on blocking upstream tyrosine kinases to inhibit STAT3/5, but these …

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Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment

Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca et autres

White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH …

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880P Paclitaxel plus cetuximab for the treatment of recurrent and/or metastatic head and neck cancer after first-line checkpoint inhibitor failure: Primary analysis from the pace ace trial

Thorsten Fuereder, Konrad Friedrich Klinghammer, D.A. Hahn, Birgit Grünberger et autres

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Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia

Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge et autres

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector functions such as STAT5A and STAT5B hyperactivation are poorly understood. Here, we studied the most frequent and clinically challenging …

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Automated Mass Photometry of Adeno-Associated Virus Vectors from Crude Cell Extracts

Christina D. Wagner, Felix F. Fuchsberger, Bernd Innthaler, Robert Pachlinger et autres

Mass photometry (MP) is a fast and simple analysis method for the determination of the proportions of subpopulations in an AAV sample. It is label-free and requires minimal sample volumes between 5-10 µL, which makes it a promising candidate over orthogonal techniques …

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Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphoma

Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. de Araujo et autres

Abstract Background: The oncogenic transcription factors STAT3, STAT5A and STAT5B are essential to steer hematopoiesis and immunity, but their enhanced expression and activation drives the development or progression of blood cancers, such as AML and NKCL. Current therapeutic strategies to inhibit STAT3/5 …

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Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphoma

Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. de Araujo et autres

Abstract The oncogenic transcription factors STAT3, STAT5A and STAT5B are essential to steer hematopoiesis and immunity, but their enhanced expression and activation drives the development or progression of blood cancers. Current therapeutic strategies focus on blocking upstream tyrosine kinases, but frequently occurring …

at, ca, fi, dk, in, no, de (code pays fourni par la source)

Quantification of Empty, Partially Filled and Full Adeno-Associated Virus Vectors Using Mass Photometry

Christina D. Wagner, Felix F. Fuchsberger, Bernd Innthaler, Martin Lemmerer et autres

Adeno-associated viruses (AAV) are one of the most commonly used vehicles in gene therapies for the treatment of rare diseases. During the AAV manufacturing process, particles with little or no genetic material are co-produced alongside the desired AAV capsid containing the transgene …

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Circulating FGF18 is decreased in pleural mesothelioma but not correlated with disease prognosis

Berta O. Mosleh, Karin Schelch, Thomas T. Mohr, Thomas Klikovits et autres

BACKGROUND: Pleural mesothelioma (PM) is a relatively rare malignancy with limited treatment options and dismal prognosis. We have previously found elevated FGF18 expression in PM tissue specimens compared with normal mesothelium. The objective of the current study was to further explore the …

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Real-world Data of Palliative First-line Checkpoint Inhibitor Therapy for Head and Neck Cancer

Sandro M. Wagner, Teresa Magnes, Thomas Melchardt, Dominik Kiem et autres

BACKGROUND/AIM: Pembrolizumab alone or combined with chemotherapy is now approved in PD-L1-positive patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Since real-world data are pending, our goal was to evaluate the efficacy and safety of immune …

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