Lirong Li

Explainable machine learning-assisted Raman spectroscopy-based fast Versicolorin A detection in maize for early aflatoxin warning and safety sorting

Shaoyan Zheng, Bijun Liu, Yuhan Chen, Lirong Li et autres

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Calcium-pH interplay modulates cadmium accumulation in Arachis hypogaea: Implications for safe peanut production

Xin Tang, Yuepeng Yin, Lirong Li, Saqib Bashir et autres

Balancing soil pH and Ca supply boosted peanut yield by 41.2% in the acidic soil. Slight pH increase had limited effect on reducing Cd accumulation in peanut seeds. Ca enhanced both root Cd absorption and Cd immobilization in shoot cell walls. Balanced …

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Magnetic dummy-template molecularly imprinted polymers as selective sorbents for geosmin enrichment from water samples

Miaomiao Yu, Lirong Li, Yufeng Wu, Sai Wang et autres

In the present work, core–shell Fe 3 O 4 @SiO 2 @DMIPs were prepared using a dummy-template imprinting strategy and applied as extraction sorbents for the selective enrichment of geosmin (GSM) from water samples.

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Single-Nucleus RNA-Seq of Human and Rat Cardiomyocytes Identifies Shared and Distinct Regulators and Features of Aging and Disease

Samaneh Ekhteraei‐Tousi, Rosa Doñate Puertas, Mohamad Youness, Onne A.H.O. Ronda et autres

Age is the greatest risk factor for cardiovascular diseases, including heart failure (HF), which is a leading cause of morbidity and mortality. While left ventricular fibrosis, hypertrophy and decreased contractility are associated with cardiac aging, age is not sufficient for HF development. …

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu et autres

, Hyp significantly reduced H2O2‑induced oxidative stress in BMSCs and promoted their osteogenic differentiation. Mechanistically, Hyp was found to activate the PI3K/AKT signaling pathway, suggesting its notable role in mediating the antioxidant and osteoinductive effects of Hyp. Summarily, Hyp may effectively alleviate …

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Enhancing physicochemical, aromatic and sensory characteristics in coffee pulp wine through co-culture of indigenous non-Saccharomyces and Saccharomyces cerevisiae

Dongsheng Hu, Liumin Fan, Xiaogang Liu, Gaoji Yang et autres

, mixed starter cultures reduced the content of ethanol, total acid, and flavonoids in CPW, while improving the levels of glycerol, total phenols, total anthocyanins, monomeric phenols and antioxidant activity, especially for 1:5 and 1:10 sequential inoculation. Moreover, the 1:5 and 1:10 …

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Single-cell and spatial transcriptomics reveal intratumor heterogeneity and immune evasion in natural killer/T cell lymphoma

Shu‐Yun Ma, Biaojie Huang, Jiahui Wang, Ru Lv et autres

. Furthermore, ligand-receptor interaction analysis reveals that tumor-associated macrophages (TAMs) may facilitate immune evasion and suppress T cell activity within the TME. Collectively, our findings elucidate the cellular heterogeneity and immune landscape of NKTCL, offering potential targets for therapeutic intervention.

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Correction: One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study

Jing Lü, Shanmei Shen, Qing Ling, Bin Wang et autres

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Enhancement of terahertz radiation from hard water by ion-exchange softening

Lirong Li, Tao Shen, Haoyang Wang, Yong Zhang

This study investigates the enhancement of terahertz radiation from free-flowing water jets subjected to an ion-exchange softening process, in which divalent cations (Ca2+, Mg2+) are replaced by monovalent sodium ions (Na+). Our experiments utilize a femtosecond laser focused on free-flowing jets of …

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Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study

Huijing Shao, Chang Xu, Haoran Wang, Nan Lu et autres

BACKGROUND: While the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an atlas of the shared genetic associations of BMI …

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Nimotuzumab combined with docetaxel and cisplatin as first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma: a multicenter, phase 2 trial

Qihua Zou, Yi Cao, Fang Yu, Yuchen Zhang et autres

BACKGROUND: To evaluate the efficacy and safety of nimotuzumab combined with docetaxel and cisplatin (TPN) as the first-line therapy in patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). METHODS: on day 1) every 3 weeks for 6 cycles. The primary endpoint was …

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Chidamide, a Histone Deacetylase Inhibitor, Combined With R‐ GemOx in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma ( TRUST ): A Multicenter, Single‐Arm, Phase 2 Trial

Qihua Zou, Yuchen Zhang, Hui Zhou, Yi Cao et autres

BACKGROUND: Histone deacetylase (HDAC) inhibitors demonstrated a synergistic anti-tumor effect with rituximab and chemotherapy in preclinical studies on diffuse large B-cell lymphoma (DLBCL). This phase 2 trial aimed to evaluate the efficacy and safety of chidamide, an orally active HDAC inhibitor, plus …

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