Min Gu

Global phylogeography of H10Nx avian influenza reveals regional persistence and an intensifying poultry-associated spillover interface

Dongchang He, Ting Wang, Min Gu, Yongjuan Wang

cn (code pays fourni par la source)

Gut microbiota analysis in diabetic mice with periodontitis

Qianjia Pan, Yujie Gu, Minzhe Zhang, Mengfang Jin et autres

Objectives: This study aimed to investigate the composition and alterations of gut microbiota in mice with comorbid diabetes and periodontitis. Materials and methods: = 10 per group): healthy control group, periodontitis group, diabetes group, and diabetes with periodontitis group. Fasting blood glucose …

tw, cn (code pays fourni par la source)

Metabolic Pathways in Kidney Transplant Rejection: From Predictive Biomarkers to Potential Therapeutic Targets

Min Gu, Zijie Wang

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NA-N322S and G389D mutations synergize with PB2-627K to enhance H7N9 pathogenicity in mammals

Huafen Zheng, Yufan Chen, Ruyi Gao, Wenhao Yang et autres

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Newcastle disease virus promotes spreading infection through vimentin-dependent tight junction injury mediated by MLC/p-MLC activation

Xiaolong Lu, Qiwen Zhou, Mingzhu Wang, Meiqi Li et autres

Newcastle disease virus (NDV), a widespread poultry pathogen, spreads efficiently via the respiratory tract. However, the precise mechanism governing its spreading infection remains unclear. This study reveals that NDV-induced tight junction (TJ) injury is crucial for viral replication and spread. NDV infection …

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Clinical features of a fatal case of acute encephalitis associated with a novel influenza H3N2 recombinant virus possessing human-origin H7N9 internal genes: a descriptive study

Wenlei Wang, Xuhua Mao, Ming Li, Kaituo Liu et autres

Newly emerging or "re-emerging" influenza viruses have been regarded as a huge global threat to human public health. However, there are few reports of human deaths caused by newly emerging influenza viruses derived from pigs and poultry. Here, we described the clinical …

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E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus

Jianyu Liang, Sige Wang, Ruyi Gao, Xiaolong Lu et autres

Since 2021, the novel H10N3 has caused four cases of human infection in China, the most recent of which occurred in December 2024, posing a potential threat to public health. Our previous studies indicated that several avian H10N3 strains are highly pathogenic …

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Comparative pathogenicity of goose parvovirus across different epidemic lineages in ducklings and goslings

Xiaolong Lu, Qianqian Xu, Miao Cai, Meiqi Li et autres

The endemic status of goose parvovirus (GPV) continues to devastate the poultry industry in China. Novel GPV (NGPV) and Mutated GPV (MGPV) represent the predominant lineages. However, the comparative pathogenicity between these viruses remains poorly understood. Herein, we selected representative NGPV and …

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The Novel H10N3 Avian Influenza Virus Triggers Lethal Cytokine Storm by Activating Multiple Forms of Programmed Cell Death in Mammalian Lungs

Xin Wang, Xiyue Wang, Xiaojuan Hao, Ruyi Gao et autres

The novel H10N3 avian influenza virus (AIV) has infected four individuals since 2021 and caused severe respiratory damage, posing a significant threat to public health. However, its pathogenic mechanisms remain poorly understood. Our findings revealed that H10N3 infection induces severe lung damage …

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Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation

Jie Xu, Juan Pu, Hao Chen, Li Sun et autres

Objective To investigate the role of microvascular pericyte dysfunction in antibody-mediated rejection (ABMR) of transplanted kidneys.Methods A total of 160 patients who underwent kidney transplantation in our hospital from 2004 to 2020 were enrolled, divided into 4 groups: ABMR group (n = …

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Spray vaccination with a safe and bivalent H9N2 recombinant chimeric NDV vector vaccine elicits complete protection against NDV and H9N2 AIV challenge

Xiaoquan Wang, Jing Jie Dai, Wenhao Yang, Yao Yao et autres

Newcastle disease virus (NDV) and H9N2 avian influenza virus (AIV) represent significant pathogenic risks to the poultry industry, leading to considerable economic losses. Vaccination is a widely used preventive measure against these pathogens, yet the lack of a live bivalent vaccine targeting …

cn, mv (code pays fourni par la source)

Phosphorylation of PA at serine 225 enhances viral fitness of the highly pathogenic H5N1 avian influenza virus in mice

Manyu Zhang, Zixiong Zeng, Xia Chen, Guoqing Wang et autres

cn, mv (code pays fourni par la source)