E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus
Rattachement africain : cn, mv, hu. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Since 2021, the novel H10N3 has caused four cases of human infection in China, the most recent of which occurred in December 2024, posing a potential threat to public health. Our previous studies indicated that several avian H10N3 strains are highly pathogenic in mice and can be transmitted between mammals via respiratory droplets without prior adaptation. By analyzing the genome sequence, we found that these H10N3 viruses carry the PB2-E627V mutation, which is becoming increasingly common in several subtypes of avian influenza viruses (AIV); however, its mechanism in mammalian adaptation remains unclear. Using a reverse genetics system, we investigated the role of PB2-E627V in the adaptation of H10N3 to mammals and poultry. Our findings demonstrate that the PB2-E627V mutation is critical for the high pathogenicity of novel H10N3 in mice and its ability to be transmitted through the air among mammals. Additionally, we found that the role of PB2-627 V in promoting AIV adaptation to mammals is comparable to that of PB2-627 K. More importantly, PB2-627 V appears to be equally suited to long-term persistence in poultry. Therefore, using PB2-627 V as a novel molecular marker to assess the epidemic potential of AIV is of great significance for preventing possible influenza pandemics in the future.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus
- Date Crossref
- 08/06/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Yangzhou University Key Laboratory of Avian Bioproducts Development pays non établi dans la noticeUniversité ou école supérieure
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Binzhou Technician College pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Education pays non établi dans la noticeOrganisme public
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Ministry of Agriculture pays non établi dans la noticeOrganisme public
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Jiangsu Key Laboratory of Zoonosis pays non établi dans la noticeStructure de recherche
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Binzhou Argo-Tech Extension Center pays non établi dans la noticeInstitution
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College of Veterinary Medicine Joint International Research Laboratory of Agriculture and Agri-Product Safety pays non établi dans la noticeUniversité ou école supérieure
Key Laboratory of Avian Bioproducts Development — Yangzhou University, Binzhou Technician College et Ministry of Education, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.