Robbin Kramer

ACC1 inhibition enhances BCG-induced trained immunity by reprogramming acetyl-CoA metabolism

İlayda Baydemir, Fabian Nikolka, Özlem Bulut, Anaísa V. Ferreira et autres

nl, de, gr, au, ro (code pays fourni par la source)

Corrigendum to “BCG and β-glucan primed monocytes yield dendritic cells that hamper the induction of pro-inflammatory T cell immunity” [Cell. Immunol. 419 (2026) 105060]

Jorge Cuenca-Escalona, Robbin Kramer, Clara Marjalizo-Jimenez, Jorge Domínguez‐Andrés et autres

nl (code pays fourni par la source)

BCG and β-glucan primed monocytes yield dendritic cells that hamper the induction of pro-inflammatory T cell immunity

Jorge Cuenca-Escalona, Robbin Kramer, Clara Marjalizo-Jimenez, Dominguez-Andres Jorge et autres

Dendritic cells (DCs) are professional antigen-presenting cells that regulate inflammatory and tolerogenic immunity. Their role within trained immunity, a process in which innate immune cells exhibit memory-like characteristics, remains to be elucidated. To date, increasing evidence indicates that trained immunity underlies the …

nl (code pays fourni par la source)

Countering tumor-derived PGE2-EP2/4 signaling mediates neutrophil activation

Johanna Bödder, Robbin Kramer, Julia Minnee, Jorge Cuenca-Escalona et autres

Neutrophils have recently been demonstrated to play a variable role in cancer progression, likely due to adaptability to environmental signals that influence neutrophil phenotype and function. In the tumor microenvironment, tumor-derived prostaglandin E2 is well established as a major suppressor of immune …

nl, de, ca (code pays fourni par la source)

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

Eloïse Marques, Stephen P. Burr, Alva M. Casey, Richard J Stopforth et autres

Abstract Impaired mitochondrial bioenergetics in macrophages promotes hyperinflammatory cytokine responses, but whether inherited mtDNA mutations drive similar phenotypes is unknown. Here, we profiled macrophages harbouring a heteroplasmic mitochondrial tRNA Ala mutation ( m.5019A > G ) to address this question. These macrophages …

gb, ca, ie (code pays fourni par la source)

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo

Eloïse Marques, Stephen P. Burr, Alva M. Casey, Richard J Stopforth et autres

Abstract Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses 1–6 , but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this question using a multi-omic approach that integrates super-resolution imaging and metabolic analyses …

gb (code pays fourni par la source)

Multifaceted mitochondria in innate immunity

Eloïse Marques, Robbin Kramer, Dylan G. Ryan

The ability of mitochondria to transform the energy we obtain from food into cell phosphorylation potential has long been appreciated. However, recent decades have seen an evolution in our understanding of mitochondria, highlighting their significance as key signal-transducing organelles with essential roles …

gb (code pays fourni par la source)