H Wang

Single-cell transcriptomics reveal PD-1-loss-driven immune dysregulation of pulmonary lymphocytes during early Mycobacterium tuberculosis infection

Bing Yang, H Wang, Zhang Sj, Jinru Cai et autres

ABSTRACT Although PD-1 blockade shows strong antitumor efficacy and is being considered for chronic infections including Mycobacterium tuberculosis ( M.tb ), its influence on early lymphocyte responses to M.tb remains poorly understood. In this study, we characterized the transcriptional and developmental states …

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Next-Generation Bio-Based Battery Separators: Current Status and Future Research Opportunities

Tianyu Hu, Yunxiang Cui, H Wang, Peiwen Liu et autres

Conventional polyolefin battery separators are limited by inherent deficiencies in thermal stability, electrolyte wettability, and environmental sustainability, which collectively hinder the advancement of high-energy-density energy storage systems. In this context, biomass macromolecular materials, including cellulose, chitin/chitosan, and lignin, have emerged as promising …

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Viral protease-initiated lytic cell death as a universal antiviral mRNA therapy

Li Li, Xiuli Yan, H Wang, Hangyu Zhou et autres

cn, hk (code pays fourni par la source)

Convergent elevation of mitochondrial proton leakage improves thermogenesis in honeybees

Xiao, Lifei Qiu, H Wang, Yuanchan Fan et autres

The independent range expansions of the honeybees Apis cerana and A. mellifera from tropical origins into temperate environments have had profound ecological and agricultural impacts. Both species have convergently evolved enhanced thermogenic capacity relative to closely related taxa restricted to tropical and …

cn, jp, in, ca (code pays fourni par la source)

Value of multiparametric MRI as a potential marker to differentiate membranous nephropathy from IgA nephropathy

Rongchao Shi, H Wang, Min Li, K W Li et autres

BACKGROUND: Membranous nephropathy (MN) and IgA nephropathy (IgAN) exhibit similar clinical symptoms but differ substantially in treatment strategies and prognoses, highlighting the need for a non-invasive and precise diagnostic method. Multiparametric MRI (mpMRI) has shown great potential for the non-invasive assessment and …

cn, de (code pays fourni par la source)

Disrupted Copper Homeostasis and Impaired Retinal Development Caused by slc6a4a Deficiency in Zebrafish

Hameed Ullah Baloch, Yuan-Yuan Jing, Jia-Hao Shi, H Wang et autres

Serotonin transporter Slc6a4a functions as a transporter in serotonin reuptake and is tightly linked with serotonergic regulation and stress responses. However, few studies have investigated its role in copper homeostasis and organogenesis in an in vivo vertebrate model. In this study, we …

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Zonated mechanosensing by PIEZO1 controls liver regeneration

Yu Zhang, Ye Sun, Guang‐Kui Xu, Yue Wu et autres

The liver exhibits a marked regenerative capacity organized through distinct zones, yet how tissue mechanics coordinate zonated proliferation remains elusive. We reveal that mechanical cues critically contribute to mouse liver regeneration in a highly region-specific manner through sensing by a subpopulation of …

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Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development

Tao Zhang, Xiufeng Li, Wei Zhou, LI Zhao-lu et autres

Genes that define cell identity are often highly transcribed, but how their activity is regulated to prevent pathological dysregulation remains elusive. Using a two-tiered genetic screen, we identify a network of genes regulating hypertranscribed loci, which is notably enriched for genes mutated …

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An Oryza orphan gene confers trans-species drought tolerance

Haifu Tu, Qian Liu, Tiantian Ye, Ying Ye et autres

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High-fidelity prediction of sintering deformation in DLP-fabricated Ti6Al4V components via inverse calibration of a viscous sintering model

Juncheng Lu, H Wang, Jiaming Bai

Digital light processing (DLP)-based fabrication offers a promising route to producing high-resolution Ti6Al4V components, but severe and anisotropic shrinkage during sintering remains a major challenge for dimensional accuracy, particularly in complex geometries. Accurate prediction is hindered by the high computational cost and …

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ZBP1-driven pyroptosis-associated alveolar macrophages exacerbate epithelial dysfunction in sepsis

Feicheng Zhou, Haolin Tian, H Wang, Hongxiang Huang et autres

The lung is highly vulnerable to inflammatory injury during sepsis, and acute lung injury (ALI) is a major cause of mortality in critically ill patients. Pyroptosis amplifies immune responses by promoting the release of inflammatory cytokines, and Z-DNA binding protein 1 (ZBP1) …

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Characteristics of pulmonary perfusion and ventilation in healthy adults: a prospective observational study with phase-resolved functional lung magnetic resonance imaging

Anqi Liu, Yifei Ni, Jianping Wang, Linfeng Xi et autres

BACKGROUND: Phase-resolved functional lung magnetic resonance imaging (PREFUL-MRI) enables simultaneous, free-breathing, radiation-free assessment of regional lung perfusion and ventilation. This study aimed to provide preliminary reference data for lung perfusion and ventilation using PREFUL-MRI in healthy adults, and to characterize the physiological …

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