Shiying Wu

Antioxidant Mechanisms of Lacticaseibacillus paracasei ZFM847 and Its Oxidative Stress Regulation in Multiple Models

Ziqi Chen, Yuting Pan, Y Yuexu Chen, Fangtong Wei et autres

ABSTRACT Oxidative stress is strongly linked to persistent inflammatory responses and contributes to the development and progression of various chronic diseases. This study aimed to identify and investigate the potential antioxidant capacity and mechanisms of Lacticaseibacillus paracasei ZFM847 ( L. paracasei ZFM847) …

cn (code pays fourni par la source)

Analysis of the clinical efficacy of HIFU in the treatment of low-grade vaginal intraepithelial neoplasia

Jingxi Zhang, Xiang Li, Mengyu Chen, Shiying Wu et autres

Objective To evaluate the clinical efficacy of high-intensity focused ultrasound (HIFU) in treating low-grade intraepithelial neoplasia (VaIN-1) in the vagina.Methods Between June 2020 and December 2024, 135 patients with pathologically confirmed VaIN-1 were initially enrolled. After excluding 8 cases lost to follow-up, …

cn (code pays fourni par la source)

Proteasomal processing of the viral replicase ORF1 facilitates HEV-induced liver fibrosis

Fei Zhang, Ling-Dong Xu, Shiying Wu, Qirou Wu et autres

Chronic infections with hepatitis E virus (HEV), especially those of genotype 3 (G3), frequently lead to liver fibrosis and cirrhosis in patients. However, the causation and mechanism of liver fibrosis triggered by chronic HEV infection remain poorly understood. Here, we found that …

cn (code pays fourni par la source)

Lactic acid bacteria target NF-κB signaling to alleviate gastric inflammation

Shiying Wu, Yuenuo Luo, Fangtong Wei, Yanan Li et autres

L. plantarum ZJ316 treatment attenuated H. pylori -induced inflammation by suppressing NF-κB signaling and promoting beneficial changes in the gastric microbiota composition.

cn (code pays fourni par la source)

Lactiplantibacillus plantarum ZJ316 alleviates the oxidative stress and cellular apoptosis via modulating Nrf2/HO-1 signaling pathway

Shiying Wu, Yongqiang Chen, Fangtong Wei, Ziqi Chen et autres

Oxidative stress is vital in gastrointestinal diseases, but how lactic acid bacteria protect human gastric adenocarcinoma cells (AGS) is unclear. Here, we aimed to investigate Lactiplantibacillus plantarum ZJ316 (L. plantarum ZJ316) for its potential to alleviate oxidative stress in AGS cells and …

Exopolysaccharide from Lacticaseibacillus paracasei alleviates gastritis in Helicobacter pylori-infected mice by regulating gastric microbiota

Jianxing Yu, Ziqi Chen, Qingqing Zhou, Ping Li et autres

Introduction Many probiotics have the ability to produce extracellular polysaccharides (EPS). EPS derived from these probiotics has been confirmed to regulate the host intestinal microecological balance and alleviate the symptoms of diseases caused by gastrointestinal microecological imbalance. Results Lactic acid bacteria (LAB) …

cn (code pays fourni par la source)

Antioxidant properties and molecular mechanisms of Lactiplantibacillus plantarum ZJ316: A potential probiotic resource

Shiying Wu, Yongqiang Chen, Ziqi Chen, Qianyu Zhou et autres

Oxidative stress is a hallmark of many cancers. Probiotics with antioxidant properties have been found to alleviate oxidative stress. Lactiplantibacillus plantarum ZJ316 (L. plantarum ZJ316) is an exceptional strain that shows excellent hydrogen peroxide (H2O2) tolerance, sensitivity to the seven antibiotics (ampicillin, …

cn (code pays fourni par la source)

Reduction of the levels of 5-hydroxymethylfurfural and advanced glycation end products in milk by the combination of high pressure and moderate heat pre-incubation

Yuekun Wu, Shiying Wu, Mengyu Sun, Linqing Nie et autres

cn (code pays fourni par la source)

Targeting TBK1 attenuates ocular inflammation in uveitis by antagonizing NF-κB signaling

Si Chen, Jinfeng Kong, Shiying Wu, Chenqi Luo et autres

cn (code pays fourni par la source)

Roles of NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches

Wenlong Hao, Minghao Li, Qingmin Cai, Shiying Wu et autres

Fibrosis is a persistent inflammatory response that causes scarring and tissue sclerosis by stimulating myofibroblasts to create significant quantities of extracellular matrix protein deposits in the tissue. Oxidative stress has also been linked to the development of fibrosis in several studies. The …

cn (code pays fourni par la source)

Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation

Fansen Meng, Ruyuan Zhou, Shiying Wu, Qian Zhang et autres

Cytosolic RNA/DNA sensing elicits primary defense against viral pathogens. Interferon regulatory factor 3 (IRF3), a key signal mediator/transcriptional factor of the antiviral-sensing pathway, is indispensible for interferon production and antiviral defense. However, how the status of IRF3 activation is controlled remains elusive. …

cn, us (code pays fourni par la source)