Yu Yan

Cross-cohort insights into the association of handgrip strength transitions and burdens with cardiovascular disease risk

Hua Lin, Jike Qi, Yuchen Jiang, Yu Yan et autres

Background: Previous studies established handgrip strength (HGS) as a potential risk factor for cardiovascular diseases (CVD). However, existing studies focused exclusively on baseline HGS and neglected longitudinal changes in HGS during follow-up. Thus, our aim was to investigate the associations of transitions …

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Research on Longitudinal Control Method of Aircraft Approach Phase Based on Multi-dimensional Constrained MPC

Tao Liu, Yunli Wang, Yu Yan, Zhaozhao Du

cn (code pays fourni par la source)

Garsorasib in patients with KRAS G12C-mutated non-small-cell lung cancer: A pooled analysis of phase 1/2 study

Zhengbo Song, Ziming Li, Yiping Zhang, Pingli Wang et autres

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First-Line Tislelizumab Plus Chemotherapy in Advanced Non-Squamous Non-Small Cell Lung Cancer: PD-L1 ≥ 50% Subgroup Analysis from the RATIONALE-304 Trial

Shun Lü, Jie Wang, Yu Yan, Xinmin Yu et autres

INTRODUCTION: RATIONALE-304 compared first-line tislelizumab (a programmed cell death protein 1 inhibitor) plus chemotherapy versus chemotherapy in advanced non-squamous non-small cell lung cancer (nsq-NSCLC). This exploratory analysis focused on patients with tumor cell programmed death ligand 1 (PD-L1) expression ≥ 50%. METHODS: …

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Pan-cancer analysis of PIEZO1: a promising biomarker for diagnosis, prognosis, and targeted therapies

Qian Wang, Yu Yan, Liang Xiao, Dan Wan et autres

Introduction Piezo-type mechanosensitive channel component 1 (PIEZO1), a mechanically gated cation channel involved in calcium signaling, has been recognized as a potential oncogene in some cancers. However, its comprehensive pan-cancer role remains unexplored. Methods This study used The Cancer Genome Atlas (TCGA) …

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Single-cell sequencing combined with machine learning to identify glioma biomarkers and therapeutic targets

Yu Yan, Zhengmin Chu, Qi Zhong, Genghuan Wang

Background: The purpose of this study is to utilize single-cell sequencing data to explore glioma heterogeneity and identify key biomarkers associated with glioblastoma multiforme (GBM) relapse using machine learning. Methods: Single-cell sequencing and transcriptome data for gliomas were obtained from the GEO …

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A comprehensive exploration of the impact and contribution of polygenic risk score on age at onset of 30 complex diseases

Yuxin Liu, Yu Yan, Yuchen Jiang, Xinyi Wang et autres

OBJECTIVES: Polygenic risk score (PRS) has increasingly shown promise in predicting disease risk; however, studies examining the influence of PRS on age at onset remain limited. This study aimed to systematically assess the impact of PRS on age at onset across multiple …

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Generalized topological phase transition threshold and the enhanced dynamics in dissipatively coupled lattices

Zhi‐Xu Zhang, Kai‐Xin Hu, Yu Yan, Yu Zhang et autres

Abstract The widely recognized topological phase transition in both Hermitian and non-Hermitian Su–Schrieffer–Heeger (SSH) models serves as a significant demonstration for the presence of edge states that localize at the boundaries of the lattices. By focusing on a generalized SSH lattice that …

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Influence and role of polygenic risk score in the development of 32 complex diseases

Yuxin Liu, Wenyan Hou, Tongyu Gao, Yu Yan et autres

Background: The polygenic risk score (PRS) has been perceived as advantageous in predicting the risk of complex diseases compared to other measures. We aimed to systematically evaluate the influence of PRS on disease outcome and to explore its predictive value. Methods: We …

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Prediction of Combustion Characteristic Parameters of High Efficiency and Low Emission Hydrogen-Enriched Compressed Natural Gas Engine Under Closed-Loop Control

Hao Duan, Yu Yan, Xianfeng Ren, Xiaojun Yin et autres

Closed-loop combustion control is highly beneficial for improving the efficiency and reducing the emissions of spark ignition internal combustion engines. In this paper, the key parameter (CA50) of closed-loop combustion control and its effect on the combustion and emissions were explored experimentally …

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Targeting Fgf/Fgfr Signaling Pathways with Novel Inhibitor Yth-59 Attenuates Pulmonary Fibrosis by Modulating Immune Response and Oxidative Stress

Tinghong Ye, Yuting Xie, Xingping Su, Cailing Gan et autres

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G-HIV: A High-Resolution Long-Read Sequencing and Automated Analysis Platform for Community-Level HIV Detection

Ping Fu, Ling Ke, Bingting Wu, Huan Hu et autres

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