A comprehensive exploration of the impact and contribution of polygenic risk score on age at onset of 30 complex diseases
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Le résumé fourni par la source
OBJECTIVES: Polygenic risk score (PRS) has increasingly shown promise in predicting disease risk; however, studies examining the influence of PRS on age at onset remain limited. This study aimed to systematically assess the impact of PRS on age at onset across multiple diseases. STUDY DESIGN: Prospective cohort study METHODS: We calculated PRS with two methods (C+T and PRS-CS) and compared their predictive capability in age at onset of 30 diseases in the UK Biobank. We next evaluated the effect of PRS on age at onset and quantified the influence of PRS on disease risk across early and late onset cases. RESULTS: PRS-CS behaved better in predicting age at onset of most diseases (except for Alzheimer's disease) compared to C+T. Higher PRS was associated with earlier age at onset for 23 diseases, with the average age at onset advanced by 1.94 years. Compared to women, men faced an advanced onset for 5 diseases. Compared to average PRS (20-80 %), individuals in the top 2.5 % of the PRS distribution displayed a significantly earlier age at onset for 19 diseases, ranging from 2.85 (1.68-4.03) years advancement for gout to 13.70 (9.88-17.52) years advancement for Crohn's disease. Compared to the late-onset group, the early-onset group exhibited a greater onset risk in 21 diseases, with the early-onset risk of colon cancer being 2.78-fold higher than the late-onset risk (OR = 11.42 [9.77-12.45] vs. 3.95 [3.85-4.06], P < 0.001). CONCLUSIONS: Higher PRS generally leads to earlier age at onset, which supports the potential role of PRS in screening high early-onset risk individuals susceptible to chronic diseases.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A comprehensive exploration of the impact and contribution of polygenic risk score on age at onset of 30 complex diseases
- Date Crossref
- 01/07/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Xuzhou Medical College pays non établi dans la noticeUniversité ou école supérieure
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Huazhong University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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National Center for Chronic and Noncommunicable Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Liu Zhou Center for Disease Prevention and Control pays non établi dans la noticeOrganisme public
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School of Public Health Department of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Xuzhou Medical University Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Department of Control and Prevention of Chronic Non-communicable Diseases pays non établi dans la noticeInstitution
Xuzhou Medical College, Huazhong University of Science and Technology et National Center for Chronic and Noncommunicable Disease Control and Prevention, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.