Takahiko Yokoyama

A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation

Daisuke Kobayashi, Akihiro Urasaki, Tetsuaki Kimura, Satoshi Ansai et autres

Congenital intestinal atresia (IA) is a birth defect characterised by the absence or closure of part of the intestine. Although genetic factors are implicated, mechanistic understanding has been hindered by the lack of suitable animal models. Here, we describe a medaka (Oryzias …

jp, ie, cn (code pays fourni par la source)

Focal adhesion-related non-ciliary functions of CEP290

Kazuhiko Matsuo, Yoshiro Nakajima, Masaki Shigeta, Daisuke Kobayashi et autres

Nearly all differentiated mammalian cells possess primary cilia on their surface. Ciliary dysfunction causes ciliopathy in humans. Centrosomal protein 290 (CEP290), a ciliary protein implicated in ciliopathies, localizes to the ciliary base and the centrosome in ciliated cells. CEP290-related ciliopathies arise from …

jp (code pays fourni par la source)

Ciliary protein CEP290 regulates focal adhesion via microtubule system in non-ciliated cells 1

Kazuhiko Matsuo, Yoshiro Nakajima, Masaki Shigeta, Daisuke Kobayashi et autres

Abstract Almost all differentiated mammalian cells have primary cilia on their surface. Ciliary dysfunction causes ciliopathy in humans. Centrosomal protein 290 (CEP290) is a ciliary protein that causes ciliopathies, localizes at the cilial base in ciliated cells, whereas it localizes to the …

jp, us (code pays fourni par la source)

A genetic model of congenital intestinal atresia in medaka ( Oryzias latipes ) implicates Mypt1 in epithelial organisation

Daisuke Kobayashi, Tetsuaki Kimura, Satoshi Ansai, Kazuhiko Matsuo et autres

Abstract Congenital intestinal atresia (IA) is a birth defect characterised by the absence or closure of part of the intestine. Although genetic factors are implicated, mechanistic understanding has been hindered by the lack of suitable animal models. Here, we describe a medaka …

jp (code pays fourni par la source)

Tubular cell loss in early inv/nphp2 mutant kidneys represents a possible homeostatic mechanism in cortical tubular formation

Masaki Shigeta, Hirotaka Kanazawa, Takahiko Yokoyama

Inversion of embryonic turning (inv) cystic mice develop multiple renal cysts and are a model for type II nephronophthisis (NPHP2). The defect of planar cell polarity (PCP) by oriented cell division was proposed as the underlying cellular phenotype, while abnormal cell proliferation …

jp (code pays fourni par la source)

The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6

Yoshiro Nakajima, Hiroshi Kiyonari, Yoshiko Mukumoto, Takahiko Yokoyama

jp, gb (code pays fourni par la source)

Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes)

Daisuke Kobayashi, Anshin Asano-Hoshino, Takashi Nakakura, Toshiyuki Nishimaki et autres

jp (code pays fourni par la source)

NPHP3 controls a length of B-tubule of the axoneme of renal cilia

Lin‐Chen, Nakajima Yoshiro, Toshinobu Suzaki, Takahiko Yokoyama

Structural basis of the Inv compartment and ciliary abnormalities inInv/nphp2mutant mice

Takuma Tsuji, Kazuhiko Matsuo, Takashi Nakahari, Yoshinori Marunaka et autres

The primary cilium is a hair like structure protruding from most mammalian cells. The basic design of the primary cilium consists of a nine microtubule doublet structure (the axoneme). The Inv compartment, a distinct proximal segment of the ciliary body, is defined …

jp (code pays fourni par la source)

Identification of the causal gene of intestinal atresia using medaka mutant

Daisuke Kobayashi, Tetsuaki Kimura, Kiyoshi Naruse, Hiroyuki Takeda et autres

Ciliary subcompartments and cysto-proteins

Takahiko Yokoyama

jp (code pays fourni par la source)

Roles of a ciliary gene, Nphp2/Inv in cell cycle control

Masaki Shigeta, Nakajima Yoshiro, Kazuhiko Matsuo, Takahiko Yokoyama