Xiaoling Yuan

Abstract 5397: A novel anti-CD3×CD28×STEAP1 tri-specific T-cell engager with enhanced and durable antitumor responses in prostate cancer.

Ge Song, Aiying Xiong, Seng Zhu, Xuemei Tian et autres

Abstract Introduction: Limited efficacy has been achieved with immunotherapy for prostate cancer, largely due to an immunosuppressive or “immune desert” tumor microenvironment, poor T-cell infiltration, or lack of robust tumor-specific targets. To overcome these barriers, we have developed an anti-CD3×CD28×STEAP1 tri-specific T-cell …

Abstract 4419: Development of a first-in-class camptothecin-based antibody-drug conjugate targeting ALPP/ALPPL2 with potent antitumor activity and excellent tolerability

Rui Liu, Lingli Zhang, Fan Yang, Junjie Zhang et autres

Abstract Introduction: ALPP (alkaline phosphatase, placental) and ALPPL2 (alkaline phosphatase, placental-like 2) emerge as promising targets due to their expression across multiple solid tumors, including ovarian (60%), endometrial (50%), pancreatic (30%), and gastric cancer (15%) along with minimal expression in normal adult …

Abstract 4418: Preclinical characterization of a potential best-in-class camptothecin-based antibody-drug conjugate targeting ADAM metallopeptidase domain 9

Rui Liu, Lan Ding, Yushi Chi, Ge Song et autres

Abstract Introduction: ADAM metallopeptidase domain 9 (ADAM9), a member of the disintegrin and metalloproteinase, mediates proteolytic shedding of cytokines and growth factors. ADAM9 dysregulation promotes tumor progression, metastasis, and pathological angiogenesis. ADAM9 is overexpressed in various solid tumors, including pancreatic, lung, gastric, …

Risk factors analysis for progression to severe hepatitis in acute hepatitis E: a retrospective study of 146 hospitalized cases

Jiawei Chen, Donglin Yin, Yuanyuan Zhou, Yupan Bai et autres

BACKGROUND: Hepatitis E virus (HEV) infection typically presents as a self-limiting acute hepatitis, but a subset of patients may progress to severe hepatitis, with potential progression to liver failure or even death. Identifying clinical predictors of such severe progression is essential for …

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Drivers of Green Transition Performance Differences in China’s Resource-Based Cities: A Carbon Reduction–Pollution Control–Greening–Growth Framework

Tao Huang, Xiaoling Yuan, Rang Liu

Understanding the multidimensional sources and key drivers of differences in green transition performance (GTP) among resource-based cities is vital for accomplishing national sustainable development objectives and facilitating regional coordination. This study proposes a “Carbon Reduction–Pollution Control–Greening–Growth” evaluation framework and utilizes the entropy …

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Deconstructing the Digital Economy: A New Measurement Framework for Sustainability Research

Xiaoling Yuan, Shubei Wang

Empirical research on the impact of the digital economy on sustainable development is hampered by severe methodological challenges. Discrepancies in the theoretical foundations and construction logic of measurement frameworks have led to diverse and often conflicting conclusions, hindering the systematic accumulation of …

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The Effect of Blockchain Adoption on Corporate Sustainable Development Performance: Evidence from Chinese Listed Firms

Xiaoling Yuan, Shi Shi, Qing Di

To respond to China’s sustainable development goals, this study uses a dynamic panel data set (2009–2023) and the PSM-DID model to examine how blockchain adoption impacts corporate sustainable development performance (CSDP). The results show that blockchain significantly enhances CSDP by 9.8–12.3%, primarily …

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Coordinated Operation Strategy for Wind Farms and Cloud Energy Storage Based on Stackelberg Game and Bi-Level Control

Li Lan, Mingxing Guo, Yanyuan Qian, Zekai Chen et autres

With the increasing proportion of wind power integrated into the grid, its high randomness and intermittency pose significant challenges to grid dispatch stability and market efficiency. To address the issues of high cost and low efficiency in self-owned energy storage for wind …

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Multi-Dimensional Heterogeneous Impacts of Air Pollution on Urban Sustainable Development of China

Xiaoling Yuan, Wencai Wang, Zhaopeng Li

Since China’s reform and opening up over 40 years ago, rapid urbanization has led to significant progress, but also severe air pollution. Understanding how air pollution affects the sustainable development of different city types is crucial for formulating targeted mitigation strategies. Thus, …

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The agglomeration dilemma: how Layer upon Layer undermines the effects of development zone policies in China

Hengxu Wang, Xiaoling Yuan, Kai Zhao, Ruihan Li

Development zones have become a key policy instrument for promoting industrial development across countries, making the accurate evaluation of their policy effectiveness crucial for policy optimization. However, existing studies often overlook the moderating role of institutional environments in shaping policy outcomes. This …

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Abstract 6976: Identification of novel KAT6A/B inhibitors with enhanced antitumor activity and reduced hematologic toxicity

Rui R Liu, Yushi Chi, Xiayan Zhang, Xuemei Tian et autres

Abstract Introduction: KAT6A/B are promising targets for breast cancer therapy. A phase 1 study of the KAT6A/B inhibitor PF-07248144 showed encouraging clinical results; however, target-associated hematologic toxicity, particularly neutropenia, may hinder dose escalation. KAT6A/B inhibitors that exhibit suboptimal specificity towards other members …

The Influence of Stability in New Power Systems with the Addition of Phase Modulation Functions in Thermal Power Units

Mingyang Liu, Chunsun Tian, Xiaoling Yuan, Chenghao Li et autres

The addition of phase modulation function technology to thermal power units is one of the most effective measures to solve dynamic reactive power shortages in the construction process of new power systems. In this paper, the influence of the phase modulation function …

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