Shigang Shan

Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene

Yongfen Bao, Qingjie Chen, Yushuang Xie, Zhe Tao et autres

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MiR‐28‐5p relieves neuropathic pain by targeting Zeb1 in CCI rat models

Yongfen Bao, Suhan Wang, Yushuang Xie, Kehua Jin et autres

MicroRNAs (miRNAs) are recognized as significant regulators of neuropathic pain. Moreover, neuroinflammation can contribute a lot to the progression of neuropathic pain. MiR-28-5p has been reported to be involved in many pathological diseases. However, little is known about the function of miR-28-5p …

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Depletion of Paraspeckle Protein 1 Enhances Methyl Methanesulfonate-Induced Apoptosis through Mitotic Catastrophe

Xiangjing Gao, Guanglin Zhang, Shigang Shan, Yunlong Shang et autres

Previously, we have shown that paraspeckle protein 1 (PSPC1), a protein component of paraspeckles that was involved in cisplatin-induced DNA damage response (DDR), probably functions at the G1/S checkpoint. In the current study, we further examined the role of PSPC1 in another …

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Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway

Ying Jiang, Shigang Shan, Linfeng Chi, Guanglin Zhang et autres

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Effects of cisplatin on the contractile function of thoracic aorta of Sprague-Dawley rats

Ying Jiang, Shigang Shan, Tieer Gan, Xiaoyun Zhang et autres

DNA‑damaging agents have been reported to be associated with cardiovascular complications, however, the underlying mechanisms remain to be clarified. In the present study, the possible vascular effects of cisplatin was assessed by measuring its effects on the contractile function of thoracic aortic …

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Effect of phoxim on proliferation of mouse marrow cells

Shigang Shan

Objective To explore the effect of phoxim on the proliferation of mouse bone marrow cells.Methods Phoxim was administrated to mice at doses of 160,80,40,and 20 mg/kg·bw once by gavage.Then the changes of cell proliferation index were detected by cytogenetic method 24 hours …

Mitochondria are involved in apoptosis induced by ultraviolet radiation in lepidopteran Spodoptera litura cell line

Shigang Shan, Kaiyu Liu, Jianxin Peng, Hanchao Yao et autres

Abstract Mitochondria are involved in apoptosis of mammalian cells and even single‐cell organisms, but mitochondria are not required in apoptosis in cultured Drosophila cells such as S2 and BG2 cell lines. It is not very clear whether mitochondria are involved in apoptosis …

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