Hui Zeng

A Clinical–Radiomics Multimodal Fusion Model Integrating Preoperative CT and Intraoperative DSA for Predicting Short-Term Response to Initial TACE in Hepatocellular Carcinoma

Chenhang Sun, Yuchi Tian, Temitope Emmanuel Komolafe, Zihan Xi et autres

cn (code pays fourni par la source)

M1 macrophage-targeted glucose-functionalized nanoparticles for berberine delivery and inflammatory microenvironment remodeling in osteoarthritis therapy

Weibei Sheng, Lian Li, Jin Zhao, Shouye Ma et autres

The inflammatory microenvironment mediated by synovial macrophages, particularly the pro-inflammatory M1 subtype, plays a central role in OA progression and represents a critical therapeutic target. However, delivery strategies that enable efficient and selective targeting of M1 macrophages for modulating the inflammatory microenvironment …

cn (code pays fourni par la source)

Injectable cinnamaldehyde–loaded ZIF-8/Gallic Acid–Grafted gelatin hydrogel for enhanced angiogenesis and skin regeneration in diabetic wound healing

Bo Zhou, Chen Zhang, Sheng Dai, Jin Zhao et autres

Background Chronic diabetic wounds remain a major clinical challenge due to persistent ischemia, oxidative stress, and impaired angiogenesis. Injectable hydrogels capable of adapting to irregular wound beds and delivering bioactive cues offer promising therapeutic potential for enhancing tissue regeneration. Methods We developed …

cn (code pays fourni par la source)

An injectable phosphocreatine-grafted hydrogel incorporating hierarchically structured teriparatide/SrZnP-functionalized Zn–Cu particles for osteogenesis–angiogenesis coupling and osteoporotic bone regeneration

Haotian Qin, Zhiping Guan, Yuanhao Wang, Jin Zhao et autres

, and PTH. In vitro evaluations demonstrated that the hydrogel enhanced BMSC proliferation, osteogenic differentiation, and mineralization, promoted HUVEC migration, tube formation, and angiogenic marker expression, and simultaneously inhibited osteoclastogenesis and bacterial growth. Transcriptomic analysis and inhibitor experiments revealed a dual paracrine …

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Mapping the Research Landscape of Polyphenols in Osteoarthritis: A Bibliometric Perspective

Weibei Sheng, Siyang Cao, Haotian Qin, Peng Liu et autres

Polyphenols, a diverse group of plant-derived compounds known for their antioxidant and anti-inflammatory properties, have garnered increasing attention for their therapeutic potential in osteoarthritis (OA). However, a comprehensive bibliometric analysis of the research landscape in this field has been lacking. This study …

cn (code pays fourni par la source)

Bromodomain and Extraterminal Protein Inhibition: A Novel Therapeutic Strategy in Arthritis

Weibei Sheng, Jin Xia Zhao, Fei Yu, Deli Wang et autres

Arthritis is an inflammatory condition that affects the joints and surrounding tissues, triggered by factors such as inflammation, infection, degeneration, and trauma. The major forms of arthritis include osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA). Its pathogenesis primarily involves synovial …

cn (code pays fourni par la source)

Targeting cuproptosis opens a new chapter of nanomedicine: a scientometric and graphical analysis

Siyang Cao, Yingchen Pang, Yihao Wei, Hui Zeng et autres

cn, us, hk (code pays fourni par la source)

Hydrogel in musculoskeletal diseases: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2000 to 2025)

Weibei Sheng, Siyang Cao, Haotian Qin, Peng Liu et autres

Introduction: Hydrogels, owing to their excellent biocompatibility, tunable physicochemical properties, and ability to mimic the extracellular matrix, have emerged as promising materials for the treatment of musculoskeletal disorders, including osteoarthritis, intervertebral disc degeneration, and bone injuries. Recent advancements in smart hydrogels and …

cn, us (code pays fourni par la source)

Multifunctional Biomimetic Nanomedicine for Osteoarthritis Alleviation by Mitigating Cartilage Degeneration and Promoting Cartilage Regeneration

Yaohang Yue, Yihao Wei, Weibei Sheng, Siyang Cao et autres

Osteoarthritis (OA) is a long-standing degenerative condition of the joints, defined by the progressive loss of articular cartilage accompanied by ongoing inflammation. For OA to be effectively treated, reducing cartilage breakdown and enhancing its regeneration are essential objectives. However, OA involves chronic …

cn, hk (code pays fourni par la source)

Unveiling the dynamic trends of plant-derived exosome nanovesicles-based theranostics: through bibliometric and visualized analysis

Siyang Cao, Yingchen Pang, Yihao Wei, Deli Wang et autres

Plant-derived exosome nanovesicles (PDENs) have emerged as eco-friendly, sustainable and highly efficient platforms for drug delivery, attracting significant attention in biomedical research. As a consequence, PDENs have become a focus for multidisciplinary investigation. Despite extensive research, impartial and comprehensive evaluations of PDENs-based …

cn, hk (code pays fourni par la source)

Enhancing Specificity in Predicting Axillary Lymph Node Metastasis in Breast Cancer through an Interpretable Machine Learning Model with CEM and Ultrasound Integration

Weimin Xu, Bowen Zheng, Chanjuan Wen, Hui Zeng et autres

IntroductionThe study aims to evaluate the performance of an interpretable machine learning model in predicting preoperative axillary lymph node metastasis using primary breast cancer and lymph node features derived from contrast-enhanced mammography (CEM) and ultrasound (US) breast imaging reporting and data systems …

cn (code pays fourni par la source)

Global research trends in bone/cartilage organoids from 2010 to 2024: A bibliometric and visualization study

Aikang Li, Rongji Liang, Weibei Sheng, Xiaohao Wu et autres

Bone/cartilage organoids have garnered significant attention in regenerative medicine due to their promising applications in tissue repair and disease modeling. Despite this growing interest, there is still a gap in understanding global research trends and developments in this field. This study provides …