Ya Feng

Combination therapy of levodopa with safinamide is more effective than with rasagiline and zonisamide in Asian Parkinson’s disease patients with motor fluctuations: a systematic review and network meta-analysis of randomized controlled trials

Yue Wang, Xixi Wang, Bing-Ji Yuan, Xuan Li et autres

cn, se, sg, us (code pays fourni par la source)

ALDH2 protects against dopaminergic neuronal cell ferroptosis by enhancing the enzyme activity of PRDX6 in Parkinson’s disease

Xuan Li, Sijia Peng, Yu Wang, Xin Chen et autres

Emerging evidence suggests that ferroptosis is probably involved in the selective loss of dopaminergic neurons in Parkinson's disease (PD). Acetaldehyde dehydrogenase 2 (ALDH2) plays an important role in detoxifying lipid aldehydes derived from lipid peroxidation, a process that is closely linked to …

cn, hk (code pays fourni par la source)

Shugan Decoction Ameliorated WAS‐Induced Abnormal Colonic Motility in Rats by Inhibiting Colonic TRPV4 ‐ PGE 2 Signaling

Ya Feng, Chunyu Zhou, Youcheng He, Yue Hui Wu et autres

ABSTRACT Aim To clarify the function of transient receptor potential vanilloid 4 (TRPV4)‐prostaglandin E2 (PGE 2 ) signaling in the colon of rats with irritable bowel syndrome (IBS) induced by water‐avoidance stress (WAS). On this basis, to explore whether colonic TRPV4‐PGE 2 …

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Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules

Xinrong He, Jiapeng Zhao, Jing Zhang, Shuqin Chen et autres

Purpose: Individuals affected by restless legs syndrome (RLS) tend to have familial predispositions without fully explained by genetic variants, and transcriptomic analysis may help elucidate the pathogenic mechanisms of RLS. The study aims to investigate transcriptomic changes and underlying pathological mechanisms in …

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No Bidirectional Causal Relationship Between Traumatic Brain Injury and Parkinson's Disease: A Two‐Sample Mendelian Randomization Study

Huan Wang, Yibin Huang, Ziwen Zhu, Yanzi Peng et autres

ABSTRACT Background The incidence of Parkinson's disease (PD) is significantly increased in older people who have experienced traumatic brain injury (TBI), suggesting that TBI may be a potential risk factor for PD. However, the causal relationship remains ambiguous. Objective To investigate the …

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Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy

Yibin Huang, Lulu Tian, Ziwen Zhu, Kai-Ge Zhou et autres

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Preliminary findings of DNA hypermethylation of MDGA1 in idiopathic restless legs syndrome

Xiao-Ying Zhu, Xinrong He, Yu Tian Wang, Hong-Ming Wang et autres

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Risk factors and prognosis of acute ischemic stroke related restless legs syndrome

Xi-Xi Wang, Ye Liu, Yulei Zhang, Yu Chen Wang et autres

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Acoustic prosodic parameters associated with Parkinson's disease cognitive impairment

Ye Liu, Xixi Wang, M.L. Dawn Tan, Changpeng Wang et autres

cn, sg (code pays fourni par la source)

Metagenomics and metabolomics analysis to investigate the effect of Shugan decoction on intestinal microbiota in irritable bowel syndrome rats

Lu Hang, Enkang Wang, Ya Feng, Yan Zhou et autres

Background The effect of Shugan Decoction (SGD) on intestinal motility and visceral hypersensitivity in Water avoid stress (WAS)-induced diarrhea predominant irritable bowel syndrome (IBS-D) model rats has been confirmed. However, the mechanisms of its action involved in the treatment of IBS-D need …

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Gut microbiota plays a role in irritable bowel syndrome by regulating 5-HT metabolism

Ya Feng, Lu Hang, Yan Zhou, Feng-Ru Jiang et autres

Progress in traditional Chinese medicine study of constipation predominant irritable bowel syndrome

Yangyang Meng, En-Kang Wang, Yin-Shu Wang, Ya Feng et autres