No Bidirectional Causal Relationship Between Traumatic Brain Injury and Parkinson's Disease: A Two‐Sample Mendelian Randomization Study
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ABSTRACT Background The incidence of Parkinson's disease (PD) is significantly increased in older people who have experienced traumatic brain injury (TBI), suggesting that TBI may be a potential risk factor for PD. However, the causal relationship remains ambiguous. Objective To investigate the association between TBI and PD using Mendelian randomization (MR) analyses. Methods Four genome‐wide association databases were reviewed in detail, including GWAS Catalog, FinnGen, IEU OpenGWAS, and UK Biobank. Genetic data for TBI were obtained from the FinnGen data set, including 7430 clinically diagnosed cases and 404,751 controls, and PD was obtained from a meta‐analysis in the GWAS Catalog, including 42,792 cases and 568,693 controls. The bidirectional two‐sample MR analyses were used to investigate the causal association between TBI and PD. Results There was no evidence of a causal relationship between TBI and an increased risk of PD (IVW; OR = 1.11; 95% CI, 0.91–1.36; p = 0.308). Similarly, genetically predisposed PD was not associated with a high risk of TBI (IVW; OR = 0.96; 95% CI, 0.91–1.02; p = 0.209). Results from MR‐Egger regression, weighted mode, and weighted median analyses were consistent with those from the IVW analysis. Additional sensitivity analyses further supported the robustness of our conclusions. Conclusions No causal relationship was found between TBI and PD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- No Bidirectional Causal Relationship Between Traumatic Brain Injury and Parkinson's Disease: A Two‐Sample Mendelian Randomization Study
- Date Crossref
- 28/04/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tongji University Clinical Research Center pays non établi dans la noticeUniversité ou école supérieure
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Tongji Hospital pays non établi dans la noticeÉtablissement de santé
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East China University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Sunshine Rehabilitation Center pays non établi dans la noticeÉtablissement de santé
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Shanghai Jiao Tong University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Shanghai First People's Hospital pays non établi dans la noticeÉtablissement de santé
Clinical Research Center — Tongji University, Tongji Hospital et East China University of Science and Technology, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.