Xi Zheng

Novel ploidy-control genes ORP3 and GJB3 link aneuploidy to tumor cell invasion through microtubule and actin dynamics

Junnan Liu, Xue Wang, Anca Azoitei, Tim Eiseler et autres

de, fr (code pays fourni par la source)

Impact of loss of PRLHR on aneuploidy and initiation of bladder cancer.

Xi Zheng, Bingjie Yang, Wenya Wang, Anca Azoitei et autres

854 Background: The question still remains for the presence of yet unknown genetic modifiers in the initiation and/or progression of bladder cancer (BC). It remains challenging to identify the key factors, the mechanism and potential target behind. A genome-wide CRISPR library colony …

cn, de (code pays fourni par la source)

Neoadjuvant adebrelimab combined with chemotherapy (cisplatin/carboplatin and etoposide) for limited-stage small-cell lung cancer: a study protocol of phase 2 trial (NIUS)

Yanyang Liu, Qian Wen Huang, Long Tian, Xi Zheng et autres

INTRODUCTION: Small-cell lung cancer (SCLC) is a highly malignant neuroendocrine tumour, and concurrent chemoradiotherapy is the current recommended treatment for limited-stage SCLC. However, the overall survival (OS) of patients with SCLC remains poor. Therefore, improving the survival of patients with SCLC and …

cn (code pays fourni par la source)

Machine learning‐derived peripheral blood transcriptomic biomarkers for early lung cancer diagnosis: Unveiling tumor‐immune interaction mechanisms

Xiaohua Li, Xuebing Li, Jiangyue Qin, Lei Lei et autres

Lung cancer continues to be the leading cause of cancer-related mortality worldwide. Early detection and a comprehensive understanding of tumor-immune interactions are crucial for improving patient outcomes. This study aimed to develop a novel biomarker panel utilizing peripheral blood transcriptomics and machine …

cn (code pays fourni par la source)

Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage

Xi Zheng, Takashi Toyama, Stephanie Siu, Takayuki Kaneko et autres

Glioblastoma (GBM) is one of the most aggressive and deadly brain tumors; however, its current therapeutic strategies are limited. Selenoprotein P (SeP; SELENOP, encoded by the SELENOP gene) is a unique selenium-containing protein that exhibits high expression levels in astroglia. SeP is …

jp (code pays fourni par la source)

A Peripheral Blood Transcriptomic Biomarker Panel Identified by Multiple Machine Learning Algorithms Enables Early Diagnosis and Prognosis Prediction in Lung Cancer

Xiaohua Li, Xuebing Li, Jiangyue Qin, Lei Lei et autres

gb, cn (code pays fourni par la source)

Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics

Xue Wang, Junnan Liu, Anca Azoitei, Tim Eiseler et autres

We have recently shown that loss of ORP3 leads to aneuploidy induction and promotes tumor formation. However, the specific mechanisms by which ORP3 contributes to ploidy-control and cancer initiation and progression is still unknown. Here, we report that ORP3 is highly expressed …

us, de, cn, fr (code pays fourni par la source)

Construction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system

Jiaqi Weng, Gensuo Zheng, Jiaoli Wen, Jing Yang et autres

Conventional treatments for tumors were frequently accompanied by drawbacks and side effects. It might be useful to use the revolutionary microneedle technology which combines photothermal therapy with tumor immunotherapy. In this study, we created a microneedle drug delivery system with mercapto-modified gold …

gb, cn (code pays fourni par la source)

Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma

Xi Zheng, Felix Wezel, Anca Azoitei, Sabine Meessen et autres

Background: Telomeres are protein–DNA complexes at the tips of linear chromosomes. They protect the DNA from end-to-end fusion and exonucleolytic degradation. Shortening of telomeric DNA during aging can generate dysfunctional telomeres, promoting tumorigenesis. More recent data indicate that both short and long …

de (code pays fourni par la source)

The Role of Interleukin-1-Receptor-Antagonist in Bladder Cancer Cell Migration and Invasion

Lisa Schneider, Junnan Liu, Cheng Zhang, Anca Azoitei et autres

BACKGROUND: gene) is a potent competitive antagonist to interleukin-1 (IL1) and thereby is mainly involved in the regulation of inflammation. Previous data indicated a role of IL1RA in muscle-invasive urothelial carcinoma of the bladder (UCB) as well as an IL1-dependent decrease in …

de (code pays fourni par la source)

The expression of iNOS, PTEN and COX-2 and their relationships with apoptosis, invasion and metastasis in breast cancer

Yudian Huang, Xi Zheng, Qin-sui Wu

Objective To study the expression of iNOS, PTEN and COX-2 in the breast cancer tissues and their relationships with tumor apoptosis, invasion and metastasis. Methods Tissues were obtained from 90 patients with breast invasive ductal cancer and 30 with breast benign lesion. …

Expression of cyclooxygenase-2 in breast cancer

Xi Zheng

Objective:To study the expression of cyclooxygenase-2 (COX-2) in breast cancer tissue and normal epithelial tissue,and to study the relationship between COX-2 and the prognosis of the breast cancer.Methods:The primary breast cancer(n=98) and adjacent normal epithelial tissue(n=20) were analyzed for COX-2 expression by …