Mi Guo

Discovery of 6l with a New Skeleton of 6-Oxo- N -(4-(Quinolin-4-yloxy)phenyl)-1,6-dihydropyridine-3-carboxamide as a Dual-Action Inhibitor against JNK2 and the MKK7-JNK2 Protein–Protein Interaction for Acute Lung Injury

Qi Chen, Ke Dong, Yaping Zhan, Nan Huang et autres

The development of anti-inflammatory drugs is a research focus. Acute lung injury (ALI) is a life-threatening inflammatory syndrome that currently lacks effective pharmacotherapies. Here, we report a potential therapy for ALI by targeting c-Jun N-terminal kinase 2 (JNK2), a key regulator of …

cn, kr (code pays fourni par la source)

Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury

Pan Chen, Ke Dong, Nan Huang, Kaixin Zhang et autres

Abstract Myeloid differentiation factor 88 (MyD88) plays a pivotal role in the inflammatory response. However, the number of MyD88 inhibitors is limited, and the effectiveness of current inhibitors is constrained, hindering the progress of clinical research. Herein, thirty-nine novel MyD88 inhibitors were …

cn, kr (code pays fourni par la source)

Utility of Serum Occludin as a Prognostic Biomarker of Severe Traumatic Brain Injury and Mediation Role of Acute Lung Injury: A Two-Center Prospective Cohort Study

Shaojun Zhang, Xiufeng Ye, Mi Guo, Yidong Jin et autres

Background: Occludin is a crucial biomarker of blood-brain barrier disruption. Here, we investigated the association between serum occludin levels and poor neurological outcomes after severe traumatic brain injury (sTBI) and the mediating effect of acute lung injury (ALI). Methods: In this two-center …

cn (code pays fourni par la source)

Retraction notice to "Current knowledge of antisense long non-coding RNA in the occurrence and prognosis of skull base tumors" [Heliyon 10 (2024) e35960]

Han Zhang, Qing-Wei Lv, Ziqiang Zheng, Liangjun Shen et autres

[This retracts the article DOI: 10.1016/j.heliyon.2024.e35960.].

cn (code pays fourni par la source)

Discovery of c-Kit as a New Therapeutic Target in LPS-Induced Acute Lung Injury through Novel Phenylamide Derivative D9

Wu Luo, Ke Dong, Jintian Dai, Anqi Zhang et autres

Discovering effective anti-inflammatory drugs and targets is a critical research priority. Herein, 28 novel phenylamide derivatives were designed and synthesized. Compound D9 showed favorable anti-inflammatory activities in acute lung injury (ALI) and sepsis mouse models. The target of D9 was predicted and …

cn, kr (code pays fourni par la source)

Anti-inflammatory agents design via the fragment hybrid strategy in the discovery of compound c1 for treating ALI and UC

Mi Guo, Yu Zou, Ke Dong, Nan Huang et autres

cn, kr (code pays fourni par la source)

Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties

Pan Chen, Yu Zou, Xiemin Wang, Zhichao Chen et autres

Myeloid differentiation primary response 88 (MyD88) plays a central role in inflammatory responses and diseases. However, only a few inhibitors of MyD88 with some limits have been reported currently. Herein, we identified a lead compound ( L7 ) through virtual screening and …

cn, pl (code pays fourni par la source)

Alteration of Serum MLKL Levels and Their Association with Severity and Clinical Outcomes in Human Severe Traumatic Brain Injury: A Prospective Cohort Study

Yidong Jin, Han Zhang, Min Zhou, Shaojun Zhang et autres

Background: Mixed lineage kinase domain-like protein (MLKL), which modulates necroptosis, has been implicated in pathophysiological processes following acute brain injury. Here, serum MLKL was quantified to determine its prognostic significance in severe traumatic brain injury (sTBI). Methods: This prospective cohort study enrolled …

cn (code pays fourni par la source)

RETRACTED: Current knowledge of antisense long non-coding RNA in the occurrence and prognosis of skull base tumors

Han Zhang, Qing-Wei Lv, Ziqiang Zheng, Liangjun Shen et autres

Antisense long non-coding RNA (AS-lncRNA) represents a novel class of RNA molecules. In recent years, it has been discovered that AS-lncRNAs play crucial roles in various biological processes, particularly in the onset and progression of tumors. Skull base tumors, originating from the …

cn (code pays fourni par la source)

Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury

Yu Zou, Xiemin Wang, Pan Chen, Zhiwei Zheng et autres

UC and ALI are inflammatory diseases with limited treatment in the clinic. Herein, fragment-based anti-inflammatory agent designs were carried out deriving from cyclohexylamine/cyclobutylamine and several fragments from anti-inflammatory agents in our lab. AF-45 (IC 50 = 0.53/0.60 μM on IL-6/TNF-α in THP-1 …

cn, kr (code pays fourni par la source)

Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis

Xiaobo Li, Xinyi Huang, Yunxi Zhao, Zhiwei Zheng et autres

cn, kr (code pays fourni par la source)

Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice

Ying Zhou, Zhiteng Du, Qianqian Wu, Mi Guo et autres

cn, kr, th (code pays fourni par la source)